{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09755","protein_label":"Coiled-coil domain-containing protein 6","reviewed":true,"short_name":"DUF2046","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf2046-pf09755.yaml","source_record_id":"Pfam:PF09755","source_record_label":"Uncharacterized conserved protein H4 (DUF2046)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"D3YZP9","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09755","protein_label":"Coiled-coil domain-containing protein 6","reviewed":true,"short_name":"DUF2046","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf2046-pf09755.yaml","source_record_id":"Pfam:PF09755","source_record_label":"Uncharacterized conserved protein H4 (DUF2046)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q16204","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09755","protein_label":"PH domain-containing rcdII","reviewed":true,"short_name":"DUF2046","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf2046-pf09755.yaml","source_record_id":"Pfam:PF09755","source_record_label":"Uncharacterized conserved protein H4 (DUF2046)","source_section":"canonical_examples","taxon_id":"NCBITaxon:44689","taxon_label":"Dictyostelium discoideum","uniprot_accession":"Q54Q72","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF09755","protein_label":"","reviewed":null,"short_name":"DUF2046","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf2046-pf09755.yaml","source_record_id":"Pfam:PF09755","source_record_label":"Uncharacterized conserved protein H4 (DUF2046)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":1988,"candidate_reasons":["short_name_matches_duf","description_says_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is the conserved N-terminal 350 residues of a family of proteins of unknown function possibly containing a coiled-coil domain.","domain_architectures":34,"interpro_id":"IPR019152","known_evidence_count":null,"matches":2348,"name":"Uncharacterized conserved protein H4 (DUF2046)","partial_evidence_count":null,"pfam_id":"PF09755","proteins":2257,"proteomes":1648,"short_name":"DUF2046","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09755","structures":2,"taxa":5194,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF09755.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1988,"domain_architectures":34,"matches":2348,"proteins":2257,"proteomes":1648,"structures":2,"taxa":5194},"curation_status":"SEEDED","description":"This is the conserved N-terminal 350 residues of a family of proteins of unknown function possibly containing a coiled-coil domain.","id":"Pfam:PF09755","interpro_id":"InterPro:IPR019152","name":"Uncharacterized conserved protein H4 (DUF2046)","pfam_id":"PF09755","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF2046","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09755"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF09755.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"5f60e6956968a979784f18aa65fd7cec2f911f0c9de564ebb288bb78e4d47179"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf2046-pf09755.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09755","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf2046-pf09755.yaml"}],"pfam_ids":["PF09755"],"protein_name":"Coiled-coil domain-containing protein 6","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MADSASESDTDAAGGGPAAMQSSCSATSGGSGGGGGGKSGGIVISPFRLEELTNRLASLQQENKVLKIELETYKLKCKALQEENRDLRKASVTIQARAEQEEEFISNTLFKKIQALQKEKETLAVNYEKEEEFLTNELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKKLENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLEAEKRILQEKLDQPVSAPPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREENLRLQRKLQREMERREALCRQLSESESSLEMDDERYFNEMSAQGLRPRTVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQHMGASHGITRPSPRRSSSPDKFKRPTPPPSPNTQSPVQPPPPPPPPPMQPAVPSAAPTQPAPTQPQHPVHPSSQP","sequence_length":469,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"5c04ae6663c89c42d69fd22ec30d0a5d3ac63be210108f6c0c93e67f291b51c3","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/D3YZP9.json","taxon_id":"10090","uniprot_accession":"D3YZP9","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf2046-pf09755.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09755","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf2046-pf09755.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q16204","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF09755"],"protein_name":"Coiled-coil domain-containing protein 6","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"098b3fbefa3a013be7b7ba3cd75a2525fa7ef485f024935603e42a578984e5f5","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MADSASESDTDGAGGNSSSSAAMQSSCSSTSGGGGGGGGGGGGGKSGGIVISPFRLEELTNRLASLQQENKVLKIELETYKLKCKALQEENRDLRKASVTIQARAEQEEEFISNTLFKKIQALQKEKETLAVNYEKEEEFLTNELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKKLENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLEAEKRILQEKLDQPVSAPPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREENLRLQRKLQREMERREALCRQLSESESSLEMDDERYFNEMSAQGLRPRTVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQHMGTSHGITRPSPRRSNSPDKFKRPTPPPSPNTQTPVQPPPPPPPPPMQPTVPSAATSQPTPSQHSAHPSSQP","sequence_length":474,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"098b3fbefa3a013be7b7ba3cd75a2525fa7ef485f024935603e42a578984e5f5","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q16204.json","taxon_id":"9606","uniprot_accession":"Q16204","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Dictyostelium discoideum","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf2046-pf09755.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09755","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf2046-pf09755.yaml"}],"pfam_ids":["PF00169","PF09755"],"protein_name":"PH domain-containing rcdII","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MDSNAAEKSSKEIIEDLQRQLLTEKNRNRTLVEELKQLRDSHARIQIVTENEEEYITNKFMKYLNQLKKEKEELALKVEQEEEYLTNTLQKKMLTIMKEKVDLENQLEQEEEFIVNKLQKQIQDVMKDKKALEKRLENEINDHRSLLKLQDEVIVLRDKIKELESNGNKKEDIDALKAENFVLGQKIIREQEKLSKVNSENTKLMSNLEIDDERNFNNKSKRNRSISFPTSMASTTTTTTTSITSSTTSITSSTSSINSSGSSSTNNTCNNNSSSNIPTSPLSCSSNSSGGGGGSGSLNNSCNSNCSNSSNSSNNNCNNNNNNNNGNSKLSTGVPITRSRSSSSNSNPCLITKIVKEGWLKRKSISSSNQETLEKRYYEISTDGEMREYFDETKQIPTSQYINLDTCFQIDIVTDNPNHPGYSDIKLYIKTNSISPVEIITFSTSSNDCNDWKDTISSLMPLKR","sequence_length":464,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"9af07d2b44b429ffa7296f132c4801fdf667e5b89bc963697b1324c238f8cd5f","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q54Q72.json","taxon_id":"44689","uniprot_accession":"Q54Q72","uniprot_release":"2026_03"}],"pfam_id":"PF09755","short_name":"DUF2046","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}