{"cross_mech":[],"family":{"alphafold_models":3034,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry describes the N-terminal domain in HvfC ([swissprot:Q4QL34]), NGO_1945 ([swissprot:Q5F5I0], [pdbe:3dee]), BufC1 and various other proteins partnered with MNIO family peptide modification enzymes. HvfC, as described in Haemophilus influenzae, is a partner protein to the multinuclear nonheme iron-dependent oxidase (MNIO) enzyme HvfB [swissprot:Q4QL34], and participates in post-translational modification that converts the precursor protein HvfA (Haemophilus virulence factor A) into a copper-binding metallophore and a contributor to the cell's ability to invade host cells and survive as an intracellular pathogen [[cite:PUB00161768],[cite:PUB00161749],[cite:PUB00161769]]. The related protein NGO_1945 occurs in a similar genomic context and was previously suggested to be a DNA-binding protein [[cite:PUB00057687]]. It comprises residues 31 to 117 as a helical bundle with 4 main helices [[cite:PUB00057687]]. The C-terminal is represented by [[pfam:PF22106]].","domain_architectures":7,"interpro_id":"IPR018640","known_evidence_count":null,"matches":4947,"name":"HvfC C-terminal domain","partial_evidence_count":null,"pfam_id":"PF09836","proteins":4947,"proteomes":3810,"short_name":"HvfC_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09836","structures":1,"taxa":5510,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF09836.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3034,"domain_architectures":7,"matches":4947,"proteins":4947,"proteomes":3810,"structures":1,"taxa":5510},"curation_status":"SEEDED","description":"This entry describes the N-terminal domain in HvfC ([swissprot:Q4QL34]), NGO_1945 ([swissprot:Q5F5I0], [pdbe:3dee]), BufC1 and various other proteins partnered with MNIO family peptide modification enzymes. HvfC, as described in Haemophilus influenzae, is a partner protein to the multinuclear nonheme iron-dependent oxidase (MNIO) enzyme HvfB [swissprot:Q4QL34], and participates in post-translational modification that converts the precursor protein HvfA (Haemophilus virulence factor A) into a copper-binding metallophore and a contributor to the cell's ability to invade host cells and survive as an intracellular pathogen [[cite:PUB00161768],[cite:PUB00161749],[cite:PUB00161769]]. The related protein NGO_1945 occurs in a similar genomic context and was previously suggested to be a DNA-binding protein [[cite:PUB00057687]]. It comprises residues 31 to 117 as a helical bundle with 4 main helices [[cite:PUB00057687]]. The C-terminal is represented by [[pfam:PF22106]].","id":"Pfam:PF09836","interpro_id":"InterPro:IPR018640","name":"HvfC C-terminal domain","pfam_id":"PF09836","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"HvfC_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09836"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF09836.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"e6b3826cca3d168bd3eafc2387ea328b4c8a312807dfb1152395ffeff80caca2"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/hvfc-c-pf22106.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF22106","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/hvfc-c-pf22106.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/hvfc-n-pf09836.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09836","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/hvfc-n-pf09836.yaml"}],"pfam_ids":["PF09836","PF22106"],"protein_name":"Multinuclear nonheme iron-dependent oxidase partner protein HvfC","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MLPKSSLKETQQALANAIRLGNADPLNGYAASRLAVYTRLVRNNAFGFIDRCFVEAPLHIEPEYWKNAKENFVQNGNAHSPYFQDIAGEFLLFCQEKEIFDTNILALMDFENTQLLAEVSLAKVPEKFEWNRHSVMQLSGAAYLKSYDVDFLSSDFKQFDDTPIQAIIWRDSDFRIQQQILSELDYWLLSYLQEQPNSLENVLSALNTMVEDSTSIIPLLEQVWMKWVTSEVIYPEQR","sequence_length":238,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"d1f09013b6b0f1b803fce1f27fa997e564c9b859ca7ad6e5b466be6b8f9b5923","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P44267.json","taxon_id":"71421","uniprot_accession":"P44267","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Haemophilus influenzae (strain 86-028NP)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/hvfc-c-pf22106.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF22106","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/hvfc-c-pf22106.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/hvfc-n-pf09836.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09836","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/hvfc-n-pf09836.yaml"}],"pfam_ids":["PF09836","PF22106"],"protein_name":"Multinuclear nonheme iron-dependent oxidase partner protein HvfC","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MQPKSSLKETQQALANAIRLGNADPLNGYAESRLAVYTRLVRNNAFGFIDRCFVEAPLHIELEYWKNAKENFVQNGNAHSPYFQDIAGEFLLFCQEKEIFDTNILALMDFENTQLLAEVSLAKVPEKFEWNRHSVMQLSGAAYLKSYEVDFLSSDFKQFDDTPIQVIIWRDSDFRIQQQILSELDYWLLSYLQEQPNSLENVLSALNTMVEDSTSIIPLLEQVWMKWVTSEVIYPEQR","sequence_length":238,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"c2d2a33c9fdcabb41a3c354fc3987470d171680a4c76e24bde3d5e6c4cdfa928","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q4QL34.json","taxon_id":"281310","uniprot_accession":"Q4QL34","uniprot_release":"2026_03"}],"pfam_id":"PF09836","short_name":"HvfC_N","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}