{"cross_mech":[],"family":{"alphafold_models":7112,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain can be found in the C-terminal region of phosphatidylglycerol lysyltransferase mprF, which catalyses the transfer of a lysyl group from L-lysyl-tRNA(Lys) to to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG) [[cite:PUB00056129],[cite:PUB00109263]]. This domain can also be found in lysylphosphatidylglycerol biosynthesis bifunctional protein LysX, which is the two-domain lysyl-transferase (mprF)-lysyl-tRNA synthetase (lysU) protein is responsible for LPG production [[cite:PUB00078731]].","domain_architectures":132,"interpro_id":"IPR024320","known_evidence_count":null,"matches":11427,"name":"Phosphatidylglycerol lysyltransferase, C-terminal","partial_evidence_count":null,"pfam_id":"PF09924","proteins":11396,"proteomes":8231,"short_name":"LPG_synthase_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09924","structures":15,"taxa":12407,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF09924.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":7112,"domain_architectures":132,"matches":11427,"proteins":11396,"proteomes":8231,"structures":15,"taxa":12407},"curation_status":"SEEDED","description":"This domain can be found in the C-terminal region of phosphatidylglycerol lysyltransferase mprF, which catalyses the transfer of a lysyl group from L-lysyl-tRNA(Lys) to to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG) [[cite:PUB00056129],[cite:PUB00109263]]. This domain can also be found in lysylphosphatidylglycerol biosynthesis bifunctional protein LysX, which is the two-domain lysyl-transferase (mprF)-lysyl-tRNA synthetase (lysU) protein is responsible for LPG production [[cite:PUB00078731]].","id":"Pfam:PF09924","interpro_id":"InterPro:IPR024320","name":"Phosphatidylglycerol lysyltransferase, C-terminal","pfam_id":"PF09924","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"LPG_synthase_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09924"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF09924.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"264599a88725998ab57a71bb445d3a133aff108410eb89888079645ad6260bf5"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/aminoacyltransferase-activity-go0016755.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0016755","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/aminoacyltransferase-activity-go0016755.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/phosphatidylglycerol-lysyltransferase-activity-go0050071.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0050071","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/phosphatidylglycerol-lysyltransferase-activity-go0050071.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/bifunctional-lysylphosphatidylglycerol-flippase-synthetase-mprf-nf033480.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF033480","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/bifunctional-lysylphosphatidylglycerol-flippase-synthetase-mprf-nf033480.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/phosphatidylglycerol-lysyltransferase-c-terminal-ipr024320.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR024320","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/phosphatidylglycerol-lysyltransferase-c-terminal-ipr024320.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/lpg-synthase-c-pf09924.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09924","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/lpg-synthase-c-pf09924.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/lpg-synthase-tm-pf03706.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF03706","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/lpg-synthase-tm-pf03706.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:C0H3X7","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF03706","PF09924"],"protein_name":"Phosphatidylglycerol lysyltransferase","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"bff0d4a4e0a419ede095a97d85aa3cc268e062d5d041228814b663355cdef014","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVINGLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFGGLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEKPWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTVIYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAIVTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAVLVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLILPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAIIIVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDGNALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYHDFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEELKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEISVDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAAVIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV","sequence_length":856,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"bff0d4a4e0a419ede095a97d85aa3cc268e062d5d041228814b663355cdef014","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/C0H3X7.json","taxon_id":"224308","uniprot_accession":"C0H3X7","uniprot_release":"2026_03"}],"pfam_id":"PF09924","short_name":"LPG_synthase_C","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
