{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF09940","protein_label":"","reviewed":null,"short_name":"DUF2172","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf2172-ipr032610.yaml","source_record_id":"InterPro:IPR032610","source_record_label":"Domain of unknown function DUF2172","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09940","protein_label":"Putative polysaccharide biosynthesis protein with aminopeptidase-like domain","reviewed":true,"short_name":"DUF2172","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf2172-pf09940.yaml","source_record_id":"Pfam:PF09940","source_record_label":"Domain of unknown function (DUF2172)","source_section":"canonical_examples","taxon_id":"NCBITaxon:272562","taxon_label":"Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / IAM 19013 / LMG 5710 / NBRC 13948 / NRRL B-527 / VKM B-1787 / 2291 / W)","uniprot_accession":"Q97H19","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF09940","protein_label":"","reviewed":null,"short_name":"DUF2172","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf2172-pf09940.yaml","source_record_id":"Pfam:PF09940","source_record_label":"Domain of unknown function (DUF2172)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09940","protein_label":"Putative polysaccharide biosynthesis protein with aminopeptidase-like domain","reviewed":true,"short_name":"DUF2172","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf4910-pf16254.yaml","source_record_id":"Pfam:PF16254","source_record_label":"Domain of unknown function (DUF4910)","source_section":"canonical_examples","taxon_id":"NCBITaxon:272562","taxon_label":"Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / IAM 19013 / LMG 5710 / NBRC 13948 / NRRL B-527 / VKM B-1787 / 2291 / W)","uniprot_accession":"Q97H19","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09940","protein_label":"Putative polysaccharide biosynthesis protein with aminopeptidase-like domain","reviewed":true,"short_name":"DUF2172","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/hth-47-pf16221.yaml","source_record_id":"Pfam:PF16221","source_record_label":"winged helix-turn-helix","source_section":"canonical_examples","taxon_id":"NCBITaxon:272562","taxon_label":"Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / IAM 19013 / LMG 5710 / NBRC 13948 / NRRL B-527 / VKM B-1787 / 2291 / W)","uniprot_accession":"Q97H19","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":627,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":1,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":3},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain, found in various hypothetical prokaryotic proteins, has no known function. An aminopeptidase domain is conserved within the family, but its relevance has not been established yet. Rebuilding from PDB:3kt9 shows this is an inserted (nested domain within the amino-peptidase). The function of this small domain is not known.","domain_architectures":11,"interpro_id":"IPR032610","known_evidence_count":null,"matches":1074,"name":"Domain of unknown function (DUF2172)","partial_evidence_count":null,"pfam_id":"PF09940","proteins":1074,"proteomes":1045,"short_name":"DUF2172","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09940","structures":1,"taxa":1816,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF09940.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":627,"domain_architectures":11,"matches":1074,"proteins":1074,"proteomes":1045,"structures":1,"taxa":1816},"curation_status":"SEEDED","description":"This domain, found in various hypothetical prokaryotic proteins, has no known function. An aminopeptidase domain is conserved within the family, but its relevance has not been established yet. Rebuilding from PDB:3kt9 shows this is an inserted (nested domain within the amino-peptidase). The function of this small domain is not known.","id":"Pfam:PF09940","interpro_id":"InterPro:IPR032610","name":"Domain of unknown function (DUF2172)","pfam_id":"PF09940","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF2172","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09940"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF09940.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"7b75b55bcffbf69152137436c9bb337e1c17696c8cf6f473e4b1753e7eb290e7"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / IAM 19013 / LMG 5710 / NBRC 13948 / NRRL B-527 / VKM B-1787 / 2291 / W)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf2172-pf09940.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09940","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf2172-pf09940.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf4910-pf16254.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF16254","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf4910-pf16254.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/hth-47-pf16221.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF16221","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/hth-47-pf16221.yaml"}],"pfam_ids":["PF09940","PF16221","PF16254"],"protein_name":"Putative polysaccharide biosynthesis protein with aminopeptidase-like domain","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEEINKYIQNSSETGGEIYNLIEELFPICRSITGNGVRKTMDIIRKHIPLEIHEVKSGTKVFDWTVPKEWNIKDAYVRNSKGEKVIDFKENNLHVMSYSVPVHKTMTLDELKPYLHTIPGNKDRIPYLTSYYKENWGFSLTQNKFDELCDDDYEVVIDSSLEDGSLTYGEYYIRGELEEEILLTTYTCHPSMCNDNLSGVALITFIAKALSKLKTKYSYRFLFAPETIGSITWLSRNEDKLKNIKMGLVATCVGDAGIKNYKRTKFGDAEIDKIVEKVLMHCGSEYYVADFFPWGSDERQFSSPGINLPVGSLMRSCYGFDGYHTSADNLCYMNKDGLADSYKTYLEVIYTIENNRTYLNLNPKCEPQLGKRGIYRMIGGGSDYPFDEFAMFWVLNMSDGKNSLLDIAYKSGMEFRRIKYAADALYRVELLKLV","sequence_length":434,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"1ca5c785e695c8b557618f2496661007c03bca971086b400747aa02c1cb8c867","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q97H19.json","taxon_id":"272562","uniprot_accession":"Q97H19","uniprot_release":"2026_03"}],"pfam_id":"PF09940","short_name":"DUF2172","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}