{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09972","protein_label":"Uncharacterized protein YciQ","reviewed":true,"short_name":"DUF2207","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf2207-ipr018702.yaml","source_record_id":"InterPro:IPR018702","source_record_label":"Domain of unknown function DUF2207","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P45848","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09972","protein_label":"Uncharacterized protein MJ1577","reviewed":true,"short_name":"DUF2207","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf2207-ipr018702.yaml","source_record_id":"InterPro:IPR018702","source_record_label":"Domain of unknown function DUF2207","source_section":"canonical_examples","taxon_id":"NCBITaxon:243232","taxon_label":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","uniprot_accession":"Q58972","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF09972","protein_label":"","reviewed":null,"short_name":"DUF2207","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf2207-ipr018702.yaml","source_record_id":"InterPro:IPR018702","source_record_label":"Domain of unknown function DUF2207","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09972","protein_label":"Uncharacterized protein YciQ","reviewed":true,"short_name":"DUF2207","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/predicted-membrane-protein-yciq-like-c-terminal-domain-ipr048389.yaml","source_record_id":"InterPro:IPR048389","source_record_label":"Predicted membrane protein YciQ-like, C-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P45848","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09972","protein_label":"Uncharacterized protein MJ1577","reviewed":true,"short_name":"DUF2207","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/predicted-membrane-protein-yciq-like-c-terminal-domain-ipr048389.yaml","source_record_id":"InterPro:IPR048389","source_record_label":"Predicted membrane protein YciQ-like, C-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:243232","taxon_label":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","uniprot_accession":"Q58972","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09972","protein_label":"Uncharacterized protein YciQ","reviewed":true,"short_name":"DUF2207","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf2207-pf09972.yaml","source_record_id":"Pfam:PF09972","source_record_label":"Predicted membrane protein (DUF2207) N-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P45848","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09972","protein_label":"Uncharacterized protein MJ1577","reviewed":true,"short_name":"DUF2207","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf2207-pf09972.yaml","source_record_id":"Pfam:PF09972","source_record_label":"Predicted membrane protein (DUF2207) N-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:243232","taxon_label":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","uniprot_accession":"Q58972","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF09972","protein_label":"","reviewed":null,"short_name":"DUF2207","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf2207-pf09972.yaml","source_record_id":"Pfam:PF09972","source_record_label":"Predicted membrane protein (DUF2207) N-terminal domain","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09972","protein_label":"Uncharacterized protein YciQ","reviewed":true,"short_name":"DUF2207","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2207-c-pf20990.yaml","source_record_id":"Pfam:PF20990","source_record_label":"Predicted membrane protein (DUF2207) C-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P45848","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF09972","protein_label":"Uncharacterized protein MJ1577","reviewed":true,"short_name":"DUF2207","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2207-c-pf20990.yaml","source_record_id":"Pfam:PF20990","source_record_label":"Predicted membrane protein (DUF2207) C-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:243232","taxon_label":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","uniprot_accession":"Q58972","unknown_status":"KNOWN_HISTORICAL_DUF"}],"family":{"alphafold_models":2672,"candidate_reasons":["short_name_matches_duf"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":2,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":4},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain, found in various hypothetical bacterial proteins, has no known function.","domain_architectures":11,"interpro_id":"IPR018702","known_evidence_count":null,"matches":4100,"name":"Predicted membrane protein (DUF2207) N-terminal domain","partial_evidence_count":null,"pfam_id":"PF09972","proteins":4093,"proteomes":3457,"short_name":"DUF2207","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09972","structures":0,"taxa":5387,"unknown_status":"KNOWN_HISTORICAL_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF09972.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2672,"domain_architectures":11,"matches":4100,"proteins":4093,"proteomes":3457,"structures":0,"taxa":5387},"curation_status":"SEEDED","description":"This domain, found in various hypothetical bacterial proteins, has no known function.","id":"Pfam:PF09972","interpro_id":"InterPro:IPR018702","name":"Predicted membrane protein (DUF2207) N-terminal domain","pfam_id":"PF09972","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"KNOWN_HISTORICAL_DUF","short_name":"DUF2207","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09972"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF09972.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"fc2b7698199b2afbfb51d2de553fbb18837b01c28180d4a97f90c478383a92ee"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf2207-ipr018702.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR018702","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf2207-ipr018702.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/predicted-membrane-protein-yciq-like-c-terminal-domain-ipr048389.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR048389","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/predicted-membrane-protein-yciq-like-c-terminal-domain-ipr048389.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf2207-pf09972.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09972","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf2207-pf09972.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2207-c-pf20990.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF20990","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2207-c-pf20990.yaml"}],"pfam_ids":["PF09972","PF20990"],"protein_name":"Uncharacterized protein YciQ","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAGKFRCILLLIAGLFVSSLSYAENTEIPSYEEGISLFDVEATLQPDGVLDIKENIHFQARNQQIKHGFYRDLPRLWMQPDGDAALLNYHIVGVTRDGIPEPWHLDWHIGLMSIVVGDKQRFLPQGDYHYQIHYQVKNAFLREGDSDLLIWNVTGNHWPFEIYKTRFSLQFSNIAGNPFSEIDLFTGEEGDTYRNGRILEDGRIESRDPFYREDFTVLYRWPHALLSNASAPQTTNIFSHLLLPSTSSLLIWFPCLFLVCGWLYLWKRRPQFTPVDVIETDVIPPDYTPGMLRLDAKLVYDDKGFCADIVNLIVKGKIHLEDQSDKNQQILIRVNEGATRNNAVLLPAEQLLLEALFRKGDKVVLTGRRNRVLRRAFLRMQKFYLPRKKSSFYRSDTFLQWGGLAILAVILYGNLSPVGWAGMSLVGDMFIMICWIIPFLFCSLELLFARDDDKPCVNRVIITLFLPLICSGVAFYSLYINVGDVFFYWYMPAGYFTAVCLTGYLTGMGYIFLPKFTQTGQQRYAHGEAIVNYLARKEAATHSGRRRKGETRKLDYALLGWAISANLGREWALRIAPSLSSAIRAPEIARNGVLFSLQTHLSCGANTSLLGRSYSGGGAGGGAGGGGGGGW","sequence_length":631,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"968c00f082e5c98edce68e47aac5d2aa5dfbd6f5acfa2d0bf0060f117e14aee9","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P45848.json","taxon_id":"83333","uniprot_accession":"P45848","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf2207-ipr018702.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR018702","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf2207-ipr018702.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/predicted-membrane-protein-yciq-like-c-terminal-domain-ipr048389.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR048389","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/predicted-membrane-protein-yciq-like-c-terminal-domain-ipr048389.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf2207-pf09972.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09972","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf2207-pf09972.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2207-c-pf20990.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF20990","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2207-c-pf20990.yaml"}],"pfam_ids":["PF09972","PF20990"],"protein_name":"Uncharacterized protein MJ1577","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MREEKEIIIVCLLIFIVGVVGIFLTTSFNGMKYTSIYIKDYEANLYIGKNLTLEEIYSYEVLEGRKYRMLYRDWKAPLVYNGSLNTPYVKVLNLSTSSKDMVGYVVDYKGDIFVFSDEDWIKRNIEEIVDKYYIRNEVGFYNPLYIRNPGIYTTSYKFVIYPPIETDNVFYHINLKLADEHLPYKNVKINVIDENNSILDLFVYPSTFKVYKTYFGYTIEGSSPKNDPIEVEMLLKPNSVNGFTRYVYNVEGKTISAYKKYTFVSNIVMTLKYLLMAIILLFPLIAYIIYLKFGKEKFYVVPEYLSYVPNKNRKPWIVNLIFAGDAGFFDKEGFYATLLDLHNRGYIKIMNGGKIEILKTDLENLDVYESDVMKFLMKYSKNNVFDPEYIKSLAQKYKSSKDKLKKLKDELDKIMEYPRYSSKVVNAFLETRGKKIIIALLVISILLAVFLYFIPKYSQTFNEVFYLSIVFVVQNIILALTPTSLFGRWKANYYKEKLEWDAFKNFLSNLAMIKKYSPEDISIWKDWLIYGTALGVGDKVVEAMKSLNLSELVADYVIIHSNYDSMKTSVDSVYSSTTGSGGGFGAGGGFGGGGGGAR","sequence_length":598,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"ced5d97acaa0676aa94563a12f23d2fc690dc425f453286b939b44f6ca20aa85","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q58972.json","taxon_id":"243232","uniprot_accession":"Q58972","uniprot_release":"2026_03"}],"pfam_id":"PF09972","short_name":"DUF2207","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}