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Tle1 is organised into two distinct parts, the phospholipase catalytic module (this entry) and the putative membrane-anchoring module ([pfam:PF22137]). This domain adopts a compact conformation with a classical mixed alpha/beta-hydrolase fold that shows of seven central parallel beta-sheets and 13 alpha-helices [[cite:PUB00154252]].","id":"Pfam:PF09994","interpro_id":"InterPro:IPR018712","name":"T6SS, Phospholipase effector Tle1-like, catalytic domain","pfam_id":"PF09994","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"T6SS_Tle1-like_cat","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF09994"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF09994.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"168e90df8189f19741ea6e5530b34845ee73a3aaf11ae3df36cad986697c0934"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/t6ss-phospholipase-effector-tle1-like-catalytic-domain-ipr018712.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR018712","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/t6ss-phospholipase-effector-tle1-like-catalytic-domain-ipr018712.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/t6ss-tle1-like-cat-pf09994.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF09994","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/t6ss-tle1-like-cat-pf09994.yaml"}],"pfam_ids":["PF09994"],"protein_name":"Uncharacterized protein YEL023C","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MDSFNYIHGKYKKNGTGGDRSINPSSHSSSGKNIILCFDGTRENFGPQPFTNILKLYNLLENGDSSEQICYYQPGIGSVGFDAVVDVRRRLTISHLQNLLDSMFAFSLDNHICSAYLFLMKYFEPGDRIYMFGFSRGAFIARVLAGMIERVGLLSKGLEEMVKMAWQIYEKWEYDSQPNELQYTSTLAEEFKKTFSRDYEVKIHFQGLFDSVNSVGILRDRLFPCTQRSNIVEHVRHCVSLDERRGKFKQLCFTPMPYIPKLFSLTYCNHITDQCSPVPTSNALMRDLTPENPLIKYTLKSGAHSISNPSPLIPDNPGRLLSSKSEETTELLLDLNSFLEGNSYARDTECSTRGIEAIFQLQSIQGSGTSSRMTMTPDLIEKWFPGDHSDVGGGWAPDCETEENLSNLTLRWILAEAIKFGVKFKPGAIHDFATKHTSIGSLFADTHDYLSFNSPKKCSLLGVSDNEDGAREDKSGRNERMEDCLKNIKETRLSLKDEKEKVKDAFTLKCGHANKFMRLVWWVLELLPIGIRMENKEGKWQNFHTPNLGRSRYVPEYVSLHWSVYWRIKFDRRYRPDNMPEYVRQLFQDLEGIDLKSNKVSNKYDKQDNSNGSEINGGFFDNEEGQELHMGQKASYFATTYNSRLFDSKYSQLKKKFMDWDSNSWTDIPDDLKIYLQQDESL","sequence_length":682,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"9f1d80609d74160569eca7d237092ffe4d7d5179f3a3c67b2d339252e42869e8","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P39992.json","taxon_id":"559292","uniprot_accession":"P39992","uniprot_release":"2026_03"}],"pfam_id":"PF09994","short_name":"T6SS_Tle1-like_cat","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}