{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF10106","protein_label":"","reviewed":null,"short_name":"DUF2345","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/type-vi-secretion-system-spike-protein-vgrg2-domain-of-unknown-functio-ipr018769.yaml","source_record_id":"InterPro:IPR018769","source_record_label":"Type VI secretion system spike protein VgrG2, domain of unknown function DUF2345","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF10106","protein_label":"Type VI secretion system spike protein VgrG2a","reviewed":true,"short_name":"DUF2345","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2345-pf10106.yaml","source_record_id":"Pfam:PF10106","source_record_label":"Uncharacterized protein conserved in bacteria (DUF2345)","source_section":"canonical_examples","taxon_id":"NCBITaxon:208964","taxon_label":"Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)","uniprot_accession":"Q9I3K1","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF10106","protein_label":"Type VI secretion system spike protein VgrG2b","reviewed":true,"short_name":"DUF2345","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2345-pf10106.yaml","source_record_id":"Pfam:PF10106","source_record_label":"Uncharacterized protein conserved in bacteria (DUF2345)","source_section":"canonical_examples","taxon_id":"NCBITaxon:208964","taxon_label":"Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)","uniprot_accession":"Q9I6M7","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF10106","protein_label":"","reviewed":null,"short_name":"DUF2345","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2345-pf10106.yaml","source_record_id":"Pfam:PF10106","source_record_label":"Uncharacterized protein conserved in bacteria (DUF2345)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"KNOWN_HISTORICAL_DUF"}],"family":{"alphafold_models":2257,"candidate_reasons":["short_name_matches_duf"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":2,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"Members of this family are found in various bacterial hypothetical proteins, as well as Rhs element Vgr proteins.","domain_architectures":42,"interpro_id":"IPR018769","known_evidence_count":null,"matches":4053,"name":"Uncharacterized protein conserved in bacteria (DUF2345)","partial_evidence_count":null,"pfam_id":"PF10106","proteins":4050,"proteomes":1178,"short_name":"DUF2345","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10106","structures":3,"taxa":1787,"unknown_status":"KNOWN_HISTORICAL_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF10106.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2257,"domain_architectures":42,"matches":4053,"proteins":4050,"proteomes":1178,"structures":3,"taxa":1787},"curation_status":"SEEDED","description":"Members of this family are found in various bacterial hypothetical proteins, as well as Rhs element Vgr proteins.","id":"Pfam:PF10106","interpro_id":"InterPro:IPR018769","name":"Uncharacterized protein conserved in bacteria (DUF2345)","pfam_id":"PF10106","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"KNOWN_HISTORICAL_DUF","short_name":"DUF2345","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10106"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF10106.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"3d24c8e5d08acfd8d898f3c3c7da19ca5a13e28f950e54dee415526f6af9d393"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2345-pf10106.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10106","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2345-pf10106.yaml"}],"pfam_ids":["PF04717","PF05954","PF10106","PF13296"],"protein_name":"Type VI secretion system spike protein VgrG2a","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRQRDLKFTFVVGEGKLAFDVVEFELEEALCEPFRLNLKLASDKNAIDFRQVLDQPGTFTLWQDGRPARYVHGIVSHFTQGSSGFRRTRYELLLEPQLARLELCCNWRIFQEKSVPEILQALLKEHRVLDYEQRIYHEHLPREYCVQAGDSDHYLHDRLAFEEGLVYYFRFDEHRHTLVCSDRLYVQERIAGGPVLFSAQPEGDNPQPVLHSFRYSENVRTARQTQRDYSFKRPTYDQEHHLAGEALEHQGSSYERYDYPGRYKRSGAGRPFSESRLRGHRRDARVASVSGDDPRLIPGHAFALEGHPRADFNAWWRPVRVVHRGTQYAGQEEESADAPLGVSYDLRAELVPEDVEWRPAPLPRPRIDGPQIATVVGPAGEEIHCDEWGRVKVQFPWDREGRHDEFSTCWIRVAQNWAGADWGHMAIPRIGQEVIVDYLDGDCDQPIVTGRTYRATNRPPYALPDHKILSTIKSKEYKGSRANELRIDDTTAQISAALMSDHGASALHLGYLTHPRPEGGKPRGEGFELRTDEHGAVRAAKGLLLSTEEQLRAGAGHLDRGVVVQVLEAALKLARELGDYAGEHQGVGHDAAPQQTLQEAVRDLGHGANDESGKSNGGKPAIALSGPAGIAAATPASLTLAAGEHVDSVARQNQQVTAGQKVVINAGSDIGLFAQGGELRQITHQGPMLLQAQKNDIRLEAEQSVEVSASQQHVLVTAKEHITLMCGGAYLTLKGGNIELGMPGNFVVKAAKHSHVGPAHASTSFNAWDSTPFDDRYVLRDEATLEPLPNIAVEVIRGDGGVVKLMTDSQGRLPKQQHLAMDPVQIRILGKGSHNSDTESNT","sequence_length":842,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"3e47e370ae6bbf1d9b76dd3729dd49830f09dd7c5b9814a1a2d8f935aa050107","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9I3K1.json","taxon_id":"208964","uniprot_accession":"Q9I3K1","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2345-pf10106.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10106","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2345-pf10106.yaml"}],"pfam_ids":["PF04717","PF05954","PF10106","PF13296"],"protein_name":"Type VI secretion system spike protein VgrG2b","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRQRDLKFTFVVGEGKLAFDVVEFELEEALCEPFRLNLKLASDKNAIDFKQVLDQPGTFTLWQDGRPARYVHGIVSHFTQGSSGFRRTRYELLLEPQLARLELCCNWRIFQEKSVPEILQALLKEHRVLDYEQRIYHEHLPREYCVQAGDSDHYLHDRLAFEEGLVYYFRFDEHRHTLVCSDRLYVQERIAGGPVLFSAQPEGDNPQPVLHSFRYSENVRTARQTQRDYSFKRPTYDQEHHLAGEALEHQGSSYERYDYPGRYKRSGAGRPFTESRLRGHRRDARVASVSGDDPRLIPGHAFALEGHPRADFNAWWRPVRVVHRGTQYAGQEEESADAPLGVSYDLRAELVPEDVEWRPAPLPRPRIDGPQIATVVGPAGEEIHCDEWGRVKVQFPWDREGRHDEFSTCWIRVAQNWAGADWGHMAIPRIGQEVIVDYLDGDCDQPIVTGRTYRATNRPPYALPDHKILSTIKSKEYKGSRANELRIDDTTAQISAALMSDHGASALHLGYLTHPRPEGGKPRGEGFELRTDEHGAVRAAKGLLLSTEEQLRAGAGHLDRGVVVQVLEAALELARELGDYAGEHQGVGHDAAPQQTLQEAVRDLGHGANDESGKSNGGKPAIALSGPAGIAAATPASLTLAAGEHVDSVARQNQQVTAGQKVVINAGSDIGLFAQGGELRQITHQGPMLLQAQKNDIRLEAKQSVEVSASQQHVLVTAKEHITLMCGGAYLTLKGGNIELGMPGNFVVKAAKHSHVGAASLEAELPQFEVGETQRRFVLKQLDGQTAMPNVPYTITMANGEVIEGVTDAEGATQLLQKDAMNIAKVDMKHTKSPASAVAGIAAAVGAAVAVGKLLGGPDAEAGRALSEGEISLAKGVFGDSIDYSTVRLRDEDYVPWQGKDYVMAPNGHIYFGEELRGVADWSLESLQRQGLFIHEMTHVWQHQHGVNVLLVGAYQQARQFLLGDQYAYRLEPGKTLKDYNIEQQGDIVRDYFLEKNEFGEASANSRFAGVLKNFPTGY","sequence_length":1019,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"e29b52843dde6ed5c50b74eea51a44ac966ea76dca3f2915b24d993eb90a2425","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9I6M7.json","taxon_id":"208964","uniprot_accession":"Q9I6M7","uniprot_release":"2026_03"}],"pfam_id":"PF10106","short_name":"DUF2345","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}