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It is required for complex stability and for the addition of the TIMM22 protein to the complex [[cite:PUB00083238]].","domain_architectures":25,"interpro_id":"IPR019322","known_evidence_count":null,"matches":1147,"name":"Translocase of the Inner Mitochondrial membrane 29","partial_evidence_count":null,"pfam_id":"PF10171","proteins":1127,"proteomes":976,"short_name":"Tim29","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10171","structures":1,"taxa":3362,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF10171.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":986,"domain_architectures":25,"matches":1147,"proteins":1127,"proteomes":976,"structures":1,"taxa":3362},"curation_status":"SEEDED","description":"This is a family of proteins conserved from nematodes to humans. The function is not known. However, family members such as the import inner membrane translocase sub-unit Tim29 (C19orf52) found in human, is shown to be required for the stability of the TIM22 complex. TIM22 complex imports and inserts multi-pass trans-membrane proteins into the mitochondrial inner membrane by formation of a twin-pore translocase with components in the outer and inner membranes. TIM29 is integrated into the inner member with the C terminus exposed to the inter-membrane space and able to contact the translocase of the outer membrane. It is required for complex stability and for the addition of the TIMM22 protein to the complex [[cite:PUB00083238]].","id":"Pfam:PF10171","interpro_id":"InterPro:IPR019322","name":"Translocase of the Inner Mitochondrial membrane 29","pfam_id":"PF10171","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Tim29","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10171"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF10171.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"62ba148962f882a32bc7e2a2256448fd8cf247809434a012cff27963d31925c5"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tim29-pf10171.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10171","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tim29-pf10171.yaml"}],"pfam_ids":["PF10171"],"protein_name":"Mitochondrial import inner membrane translocase subunit Tim29","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MVTAALKRFWSGGHGEAGGEAGGATTVAVKPGLWTRLSTWAGALLRDYAEACGDAAAAARARPGRAALYVGLLGGAAACCALAPSEAAFEEALLDASGSLLLLAPATRNRHSEAFLQRLLWLRGRGRLRHVNLGFCSLVYEAPFDAQASLYQARCRYLQPRWVDFPGRILDVGFVGRWWILQNRMHDCDINDDEFLHLPAHLRVVAPHQLHSEANERLFEEKYKPIILTDDQVDQALWEEQVLQKERKDRLALSEADSLVQSDVSR","sequence_length":266,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"32cb9a0d2c806ae835f37e0a13c6da37ab488b9ed3703583fed2ae387a277761","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8BGX2.json","taxon_id":"10090","uniprot_accession":"Q8BGX2","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/tim29-pf10171.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10171","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/tim29-pf10171.yaml"}],"pfam_ids":["PF10171"],"protein_name":"Mitochondrial import inner membrane translocase subunit Tim29","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAAAALRRFWSRRRAEAGDAVVAKPGVWARLGSWARALLRDYAEACRDASAEARARPGRAAVYVGLLGGAAACFTLAPSEGAFEEALLEASGTLLLLAPATRNRESEAFVQRLLWLRGRGRLRYVNLGLCSLVYEAPFDAQASLYQARCRYLQPRWTDFPGRVLDVGFVGRWWVLGAWMRDCDINDDEFLHLPAHLRVVGPQQLHSETNERLFDEKYKPVVLTDDQVDQALWEEQVLQKEKKDRLALSQAHSLVQAEAPR","sequence_length":260,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"c9a87b6716c954286e12689cd625c12590b784d0647313fc38a6cf16f92708ee","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q9BSF4.json","taxon_id":"9606","uniprot_accession":"Q9BSF4","uniprot_release":"2026_03"}],"pfam_id":"PF10171","short_name":"Tim29","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}