{"cross_mech":[],"family":{"alphafold_models":1643,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain is found towards the N-terminal of Neuron-derived neurotrophic factor (NDNF) which contains the first fibronectin type III domain and one of the predicted N-linked glycosylation sites [[cite:PUB00092493],[cite:PUB00092492]]. NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization.","domain_architectures":28,"interpro_id":"IPR055271","known_evidence_count":null,"matches":1834,"name":"Neuron-derived neurotrophic factor, first Fn(III) domain","partial_evidence_count":null,"pfam_id":"PF10179","proteins":1828,"proteomes":1030,"short_name":"NDNF","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10179","structures":0,"taxa":3297,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF10179.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1643,"domain_architectures":28,"matches":1834,"proteins":1828,"proteomes":1030,"structures":0,"taxa":3297},"curation_status":"SEEDED","description":"This domain is found towards the N-terminal of Neuron-derived neurotrophic factor (NDNF) which contains the first fibronectin type III domain and one of the predicted N-linked glycosylation sites [[cite:PUB00092493],[cite:PUB00092492]]. NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization.","id":"Pfam:PF10179","interpro_id":"InterPro:IPR055271","name":"Neuron-derived neurotrophic factor, first Fn(III) domain","pfam_id":"PF10179","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"NDNF","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10179"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF10179.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"10e872cf8b09d2d7f95436732773a48b3fe8cd2b904e846112044bbe5cb65ee5"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/neuron-derived-neurotrophic-factor-first-fn-iii-domain-ipr055271.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR055271","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/neuron-derived-neurotrophic-factor-first-fn-iii-domain-ipr055271.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/neuron-derived-neurotrophic-factor-n-terminal-domain-ipr056225.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR056225","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/neuron-derived-neurotrophic-factor-n-terminal-domain-ipr056225.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-ndnf-c-terminal-ipr045805.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR045805","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-ndnf-c-terminal-ipr045805.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/ndnf-c-pf19433.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF19433","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/ndnf-c-pf19433.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/ndnf-n-pf24354.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF24354","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/ndnf-n-pf24354.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/ndnf-pf10179.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10179","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/ndnf-pf10179.yaml"}],"pfam_ids":["PF10179","PF19433","PF24354"],"protein_name":"Protein NDNF","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MELFYWCLLCLLLPLTSRTQKLPTRDEELFQMQIRDKEFFHDSSVIPDGAEVSSYLFRDTPRRYFFMVEEDNTPLSVTVTPCDAPLEWKLSLQELHEGSSADGSGDPELLDQQKQQMTDVEGTELFSYKGNDVEYFLSSSSPSGLYQLELLSTEKDTHFKVYATTTPESDQPYPELPYDPRVDVTSFGRTTVTLAWKPSPTASILKQPIEYCVVINKEHNFKSLCAAETKMNADDAFMVAPKPGLDFNPFDFAHFGFPTDNLGKDRSLLAKPSPKVGRHVYWRPKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFMVNTNTNMSTAYVGAFVRTKEEAKQKTVELKDGRVTDVFVKRKGKKFLRFAPVSSHQKVTFFIHSCMDAVQVQVRRDGRLLLSQNVEGIRQFQLRGKPKGKYLIRLKGNRKGASKLKILATTRPSKHAFPSLPEDTRIKAFDKLRTCSSVTVAWLGTQERRKFCIYRKEVDGNYSEDQKRREQNQCLGPDTRKKSEKVLCKYFHSQNLQKAVTTETIRDLQPGKSYLLDVYVVGHGGHSVKYQSKIVKTRKVC","sequence_length":568,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"a0bb4b907889be1e6f180ca61b03ecda42b6b7e31fcfc596eeb2a98317755670","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q8C119.json","taxon_id":"10090","uniprot_accession":"Q8C119","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/gonadotrophin-releasing-hormone-neuronal-migration-to-the-hypothalamus-go0021828.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0021828","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/gonadotrophin-releasing-hormone-neuronal-migration-to-the-hypothalamus-go0021828.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/neuron-derived-neurotrophic-factor-first-fn-iii-domain-ipr055271.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR055271","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/neuron-derived-neurotrophic-factor-first-fn-iii-domain-ipr055271.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/neuron-derived-neurotrophic-factor-n-terminal-domain-ipr056225.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR056225","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/neuron-derived-neurotrophic-factor-n-terminal-domain-ipr056225.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-ndnf-c-terminal-ipr045805.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR045805","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-ndnf-c-terminal-ipr045805.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/ndnf-c-pf19433.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF19433","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/ndnf-c-pf19433.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/ndnf-n-pf24354.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF24354","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/ndnf-n-pf24354.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/ndnf-pf10179.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10179","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/ndnf-pf10179.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q8TB73","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF10179","PF19433","PF24354"],"protein_name":"Protein NDNF","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"c104d47b5f3b6894139103843b997b17da7041b2520d2290bf5b6c08b6ac114a","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MVLLHWCLLWLLFPLSSRTQKLPTRDEELFQMQIRDKAFFHDSSVIPDGAEISSYLFRDTPKRYFFVVEEDNTPLSVTVTPCDAPLEWKLSLQELPEDRSGEGSGDLEPLEQQKQQIINEEGTELFSYKGNDVEYFISSSSPSGLYQLDLLSTEKDTHFKVYATTTPESDQPYPELPYDPRVDVTSLGRTTVTLAWKPSPTASLLKQPIQYCVVINKEHNFKSLCAVEAKLSADDAFMMAPKPGLDFSPFDFAHFGFPSDNSGKERSFQAKPSPKLGRHVYSRPKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFVVNINSNMSTAYVGTFARTKEEAKQKTVELKDGKITDVFVKRKGAKFLRFAPVSSHQKVTFFIHSCLDAVQIQVRRDGKLLLSQNVEGIQQFQLRGKPKAKYLVRLKGNKKGASMLKILATTRPTKQSFPSLPEDTRIKAFDKLRTCSSATVAWLGTQERNKFCIYKKEVDDNYNEDQKKREQNQCLGPDIRKKSEKVLCKYFHSQNLQKAVTTETIKGLQPGKSYLLDVYVIGHGGHSVKYQSKVVKTRKFC","sequence_length":568,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"c104d47b5f3b6894139103843b997b17da7041b2520d2290bf5b6c08b6ac114a","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q8TB73.json","taxon_id":"9606","uniprot_accession":"Q8TB73","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/glycosylation-dependent-protein-binding-go0140032.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0140032","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/glycosylation-dependent-protein-binding-go0140032.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/cell-proliferation-involved-in-imaginal-disc-derived-wing-morphogenesis-go0090255.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0090255","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/cell-proliferation-involved-in-imaginal-disc-derived-wing-morphogenesis-go0090255.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/extracellular-regulation-of-signal-transduction-go1900115.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1900115","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/extracellular-regulation-of-signal-transduction-go1900115.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/neuron-derived-neurotrophic-factor-first-fn-iii-domain-ipr055271.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR055271","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/neuron-derived-neurotrophic-factor-first-fn-iii-domain-ipr055271.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-ndnf-c-terminal-ipr045805.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR045805","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-ndnf-c-terminal-ipr045805.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/ndnf-c-pf19433.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF19433","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/ndnf-c-pf19433.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/ndnf-pf10179.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10179","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/ndnf-pf10179.yaml"}],"pfam_ids":["PF10179","PF19433"],"protein_name":"Protein NDNF","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MQRSTMLPGVELLLLFLLSTSLHAEISHLPMASNRIILDSTELLQNPLIQDAGVPAARATPLPPQKCPSLQRYRKMLKDFDDLEDLYVDVPVHIALAERQRKRFVLNLNDSTPLTIRFSAPVGRKMYYNQTGNPLRPAAVAPGPGVAVGSLVLPCALRGQYDLFVLARHSGALKVDALAEHPQHDWPLLNATHRIAIRTQNRVRKREMIVKWERSKFDFHVMHYCLVIQRLSMDTPRMIFTNFCQAVSAYTDQQPMTPSCAAGGPLEGIWGAPPQRERRLNPRQNVHIVCTGKRRQQLLRRLLPRSSYHLDLFGIHQGRQNLTLRLASSQVNFNRTQPLALKQQALMQLKIGGQHGKQVYSFKVPQTTRQLGEPFMRHLLIPCSGSEIRVKLLRQRSEVGKTEAFYSPTYIRQKGVLPGERYLMRFEPSNDDEALRAQKVMVALSSEALFRDLPELPQNTTVFNVRTRCSRATIAWNGSPDERELSYCIIVFNLPQRNRSVVDFTNYCMDFVPKRVMQYRYFEWMTCRERQQSPDNIETETILNLMPGSSYLVYVTANLSMGKPLPYQALTLHMASQCLDGSHESFY","sequence_length":587,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"475a335ba8bd8aab57e936b181a50c5550693b79844095a2af2b0cf8cd5a9a39","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q9W192.json","taxon_id":"7227","uniprot_accession":"Q9W192","uniprot_release":"2026_03"}],"pfam_id":"PF10179","short_name":"NDNF","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
