{"cross_mech":[],"family":{"alphafold_models":7859,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is a family of proteins conserved from fungi to humans, including fungal Inclusion body clearance protein Iml2 protein, animal tetratricopeptide repeat protein 39A/B/C (TT39A/B/C) and some uncharacterised proteins. Members of this family carry a tetratricopeptide repeat [pfam:PF07719] at their C terminus. This entry includes Iml2 and its paralogue-YKR018C from S. cerevisiae; Iml2 localises to the cytoplasm and nucleus [[cite:PUB00016470]], and its expression is increased in response to DNA replication stress [[cite:PUB00066967]]. It is found to be involved in lipid droplet-mediated inclusion body clearing after protein folding stress [[cite:PUB00088292]]. In humans, TTC39A (also known as DEME6) is expressed in primary breast carcinomas but not in normal breast tissue, and has a putative eukaryotic RNP-1 RNA binding region and a candidate anchoring transmembrane domain. It is coordinately regulated with oestrogen receptor, but is not necessarily oestradiol-responsive [[cite:PUB00044224]]. TTC39B has been linked to lipid metabolism [[cite:PUB00072592]].","domain_architectures":143,"interpro_id":"IPR019412","known_evidence_count":null,"matches":9867,"name":"Iml2/Tetratricopeptide repeat protein 39","partial_evidence_count":null,"pfam_id":"PF10300","proteins":9006,"proteomes":2835,"short_name":"Iml2-TPR_39","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10300","structures":0,"taxa":7559,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF10300.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":7859,"domain_architectures":143,"matches":9867,"proteins":9006,"proteomes":2835,"structures":0,"taxa":7559},"curation_status":"SEEDED","description":"This is a family of proteins conserved from fungi to humans, including fungal Inclusion body clearance protein Iml2 protein, animal tetratricopeptide repeat protein 39A/B/C (TT39A/B/C) and some uncharacterised proteins. Members of this family carry a tetratricopeptide repeat [pfam:PF07719] at their C terminus. This entry includes Iml2 and its paralogue-YKR018C from S. cerevisiae; Iml2 localises to the cytoplasm and nucleus [[cite:PUB00016470]], and its expression is increased in response to DNA replication stress [[cite:PUB00066967]]. It is found to be involved in lipid droplet-mediated inclusion body clearing after protein folding stress [[cite:PUB00088292]]. In humans, TTC39A (also known as DEME6) is expressed in primary breast carcinomas but not in normal breast tissue, and has a putative eukaryotic RNP-1 RNA binding region and a candidate anchoring transmembrane domain. It is coordinately regulated with oestrogen receptor, but is not necessarily oestradiol-responsive [[cite:PUB00044224]]. TTC39B has been linked to lipid metabolism [[cite:PUB00072592]].","id":"Pfam:PF10300","interpro_id":"InterPro:IPR019412","name":"Iml2/Tetratricopeptide repeat protein 39","pfam_id":"PF10300","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Iml2-TPR_39","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10300"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF10300.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"c3e3c67e6d862c6cebabcea7eb738743321717efeb18e07e887f55a70c1f5bf2"}},"protein_examples":{"candidate_count":5,"discovery_scanned":true,"example_count":5,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / 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sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/iml2-tpr-39-pf10300.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10300","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/iml2-tpr-39-pf10300.yaml"}],"pfam_ids":["PF10300","PF13181"],"protein_name":"Tetratricopeptide repeat protein 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39B","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MALVGSRVELDADEDIFEDALETISRSPSDMATSGFHFVPCETKRTSRQLGASAMGRPEGSSAKVDLKSGLEECAEALNLFLSNKFKDALELLRPWAKESMYHALGYSTIVVLQAVMTFEQQDIQNGISAMKDALQTCQKYRKKCTVVESFSSLLSRGSLEQLSEEEMHAEICYAECLLQKAALTFVQDENMINFIKGGLKIRTSYQIYKECLSILHVIQKNKQEQHFFYEFEGGVKLGTGAFNLMLSLLPARIIRLLEFIGFSGNRDLGLLQLREGASGSSMRSPLCCLTILAFHTYISLILGTGEVNVVEAESLLAPFLQQFPNGSLILFYHARIELLKGNTEKAQETFRKCISVQEEWKQFHHLCYWELMWIHIYQQNWMQAYYYSDLLCKESKWSKATYVFLKAAILSMLPEEEVAATKENVVSLFRQVDGLKQRIAGKSLPTEKFAVRKARRYSPPSGVPGKLVMPALEMMYVWNGFSIVGKRKDLSENLLVTVEKAEEALQNQDFTDYSVDDECLVKLLKGCCLKNLERPLQAELCFNHVVESEKLLKYDHYLVPFTLFELAFLYKSQGEIDKAIKVLETARNNYKDYSLESRLHFRIQAALHLWKKPSTD","sequence_length":617,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"03e00c7252f570adb4981f11dd93f774874ca52187f1f86b853e82979cce8a71","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8BYY4.json","taxon_id":"10090","uniprot_accession":"Q8BYY4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo 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39C","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAGSEQQRPRRRDDGDSDAAAAAAAPLQDAELALAGINMLLNNGFRESDQLFKQYRNHSPLMSFGASFVSFLNAMMTFEEEKMQLACDDLKTTEKLCESEEAGVIETIKNKIKKNVDVRKSAPSMVDRLQRQIIIADCQVYLAVLSFVKQELSAYIKGGWILRKAWKIYNKCYLDINALQELYQKKLTEESLTSDAANDNHIVAEGVSEESLNRLKGAVSFGYGLFHLCISMVPPNLLKIINLLGFPGDRLQGLSSLMYASESKDMKAPLATLALLWYHTVVRPFFALDGSDNKAGLDEAKEILLKKEAAYPNSSLFMFFKGRIQRLECQINSALTSFHTALELAVDQREIQHVCLYEIGWCSMIELNFKDAFDSFERLKNESRWSQCYYAYLTAVCQGATGDVDGAQIVFKEVQKLFKRKNNQIEQFSVKKAERFRKQTPTKALCVLASIEVLYLWKALPNCSFPNLQRMSQACHEVDDSSVVGLKYLLLGAIHKCLGNSEDAVQYFQRAVKDELCRQNNLYVQPYACYELGCLLLDKPETVGRGRALLLQAKEDFSGYDFENRLHVRIHAALASLRELVPQ","sequence_length":583,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"7e1b63fbc308931640b5574fc20c705f2178d417899c5b06d22449a9498a7bf7","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q8N584.json","taxon_id":"9606","uniprot_accession":"Q8N584","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus 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