{"cross_mech":[],"family":{"alphafold_models":991,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"Family of HAD domain phophoesterases observed in large eukaryotic proteins with predicted role in RNA repair, the so-called 'Swiss Army Knife' repair proteins. May be involved in phosphate group removal during RNA re-ligation [[cite:PUB00091037]].There are two characteristic sequence motifs, GGWW and TGR.","domain_architectures":24,"interpro_id":"IPR018812","known_evidence_count":null,"matches":1192,"name":"HAD domain family 1 in Swiss Army Knife RNA repair proteins","partial_evidence_count":null,"pfam_id":"PF10307","proteins":1186,"proteomes":1103,"short_name":"HAD_SAK_1","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10307","structures":0,"taxa":2287,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF10307.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":991,"domain_architectures":24,"matches":1192,"proteins":1186,"proteomes":1103,"structures":0,"taxa":2287},"curation_status":"SEEDED","description":"Family of HAD domain phophoesterases observed in large eukaryotic proteins with predicted role in RNA repair, the so-called 'Swiss Army Knife' repair proteins. May be involved in phosphate group removal during RNA re-ligation [[cite:PUB00091037]].There are two characteristic sequence motifs, GGWW and TGR.","id":"Pfam:PF10307","interpro_id":"InterPro:IPR018812","name":"HAD domain family 1 in Swiss Army Knife RNA repair proteins","pfam_id":"PF10307","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"HAD_SAK_1","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10307"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF10307.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"88ebbcf773f425e439a08a310437473a085d905f89c8ac97fff68d133c055879"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/swiss-army-knife-rna-repair-protein-had-domain-ipr018812.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR018812","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/swiss-army-knife-rna-repair-protein-had-domain-ipr018812.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/ymr265c-like-c-terminal-ipr056904.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR056904","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/ymr265c-like-c-terminal-ipr056904.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/had-sak-1-pf10307.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10307","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/had-sak-1-pf10307.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/ymr265c-c-pf25108.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF25108","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/ymr265c-c-pf25108.yaml"}],"pfam_ids":["PF10307","PF25108"],"protein_name":"Uncharacterized protein YMR265C","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEEFEEFRRKGEMSSRCGNHRVLRKWNSCACELAVPFEVPEHAITKLHIYDFDNTLFATPGPTEQLYTRELLNLLTSSTLPNGGWWNEPGFLQAAIEISKTKPRRYSWNADIVKLAEESYSAKDTISIVLTGREESKFHKLIEHALQTARSHWKCSENEFRFNAVCLKKRAISEYTSKYKKELMRDFLEYYPSLRELSIYDDRIHQIDAFKSFFHSLDLPRLKWSAIPVRPFTKSLPREQELEMVMDMVRKNNSQALSTSQKFDLRRTPRQIGYILCTASHRLLSIEVIKYLKRRKGRRTFRPKLYEHPLYIPCAEPGKDIPALEIAKVWSNNDTRTFDSEKKVQHISQIFYLEQPGKCIVHFQVTDLAVIASAHHNRRKPLEVYFKATPEPNRYTFTLFPEYIVTGHFYKRDRIEDLEVVTERLINCKEDIHWVPLDNTIPIKAFFGRFAKLAAIPCSNA","sequence_length":461,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"154d1461fe53526496dc265cc0145f38710472e9edc42244fd66a6a39b1d7079","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q03508.json","taxon_id":"559292","uniprot_accession":"Q03508","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Schizosaccharomyces pombe (strain 972 / ATCC 24843)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/had-sak-1-pf10307.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10307","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/had-sak-1-pf10307.yaml"}],"pfam_ids":["PF10307"],"protein_name":"Uncharacterized protein C4.02c","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSLNVDIGLGTYDFSKWGYIDVHKIKEVHIYDFDNTLFQTPLPNANIWSNQAIRILMAFNILANGGWFFDPHVLAATGDGVEVEEKRAWEGWWNEKIVSQARESIRRPDVLAVLLTGRNEGFRGIVEKIIASKGLDFQGVVFKLQAPDGFWPQTLNFKLWFFNEVYRHFLYINSTRIYEDRPSHIEAFSAWLTERKKKNKNADFEIIAVAEPPKYLKFKVEIALVRGMLTAHNLKAPSLKLPLYKFVKNVIATVVTVPVAELHHIRNAFFNIPIAEIMESVSANSSRRNSHDSNSTIICEPEYPPDTSFNSSPGRLWIVTAIGRYRDEYWTVRAEAAEGYDCEKIHEIDVADIPSLYGTILYVSMSTGIVKSEIGDIGAQQWKTLAPSERWILRTNIRKECTYDIRYKRPYVSSLKYSDDDLTAGRASPMTGPTKRK","sequence_length":437,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"339873e43c9255cb3b3ecd0fa5a061bb996d4bb1ab1e54a3566da9eca45b90d5","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q9USS8.json","taxon_id":"284812","uniprot_accession":"Q9USS8","uniprot_release":"2026_03"}],"pfam_id":"PF10307","short_name":"HAD_SAK_1","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
