{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF10310","protein_label":"Maintenance of telomere capping protein 1","reviewed":true,"short_name":"DUF5427","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf5427-pf10310.yaml","source_record_id":"Pfam:PF10310","source_record_label":"Domain of unknown function (DUF5427)","source_section":"canonical_examples","taxon_id":"NCBITaxon:284812","taxon_label":"Schizosaccharomyces pombe (strain 972 / ATCC 24843)","uniprot_accession":"O94548","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF10310","protein_label":"Maintenance of telomere capping protein 1","reviewed":true,"short_name":"DUF5427","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf5427-pf10310.yaml","source_record_id":"Pfam:PF10310","source_record_label":"Domain of unknown function (DUF5427)","source_section":"canonical_examples","taxon_id":"NCBITaxon:559292","taxon_label":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","uniprot_accession":"P47018","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF10310","protein_label":"","reviewed":null,"short_name":"DUF5427","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf5427-pf10310.yaml","source_record_id":"Pfam:PF10310","source_record_label":"Domain of unknown function (DUF5427)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":1205,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","description_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":2,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is a domain of unknown function. Family members found in Saccharomyces cerevisiae, are synthetic lethal with genes involved in maintenance of telomere capping [[cite:PUB00035474],[cite:PUB00059200]]. However, experimental evidence is yet to verify the exact function of family members and the domain.","domain_architectures":10,"interpro_id":"IPR018814","known_evidence_count":null,"matches":1472,"name":"Domain of unknown function (DUF5427)","partial_evidence_count":null,"pfam_id":"PF10310","proteins":1436,"proteomes":1389,"short_name":"DUF5427","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10310","structures":0,"taxa":2883,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF10310.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1205,"domain_architectures":10,"matches":1472,"proteins":1436,"proteomes":1389,"structures":0,"taxa":2883},"curation_status":"SEEDED","description":"This is a domain of unknown function. Family members found in Saccharomyces cerevisiae, are synthetic lethal with genes involved in maintenance of telomere capping [[cite:PUB00035474],[cite:PUB00059200]]. However, experimental evidence is yet to verify the exact function of family members and the domain.","id":"Pfam:PF10310","interpro_id":"InterPro:IPR018814","name":"Domain of unknown function (DUF5427)","pfam_id":"PF10310","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF5427","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10310"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF10310.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"0d19d5a7644bd4520c3151808745e2a6097584dbe21cb5722d456a5ceb6e4553"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Schizosaccharomyces pombe (strain 972 / ATCC 24843)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf5427-pf10310.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10310","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf5427-pf10310.yaml"}],"pfam_ids":["PF10310"],"protein_name":"Maintenance of telomere capping protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAETKEQTDDVETLMASLDQLGMEADPTSKEFNNDDSKIGAPSEVQDEKELLEFLDQLENDEEKNEKNPIEEANEENESVAATSNERQQHDASNQPSQAAQTTINKNTESATPKTVNEINKSQEFQEHVETPKQSNWLGGFWSTASAAVRSAEQRVRSIKGFEENANWDINVRNMVDLNKLGDLSNGIRSKALPTLSNTIHNVLNVVAPPIHDHEVLQVTVFHDLAGFAHLDRIVYESFEKVMFQVEGGELTVLLDKEAKVRPRTNDVYEDFGLCNGYLEAKKLAKANLAEPITEAKKMNKENKQENVGAGDDEDASESPMVRVTHLLLVIQAFTIKNKEVSDDEQLCFLIHLNDTNHNLEFSTTSQPLPLEWQRWAVDPRYIKLFGSNAILPNEWVTEWVEQSISVAAGIVAQMYTSKRMALGDPSLFAGLPEEDVNTGSSETPVPYYDGAMYA","sequence_length":455,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"805d44207ad8cefb2c7e7f5f36c24f060cc200b2d5b576d427489a3371a1f095","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/O94548.json","taxon_id":"284812","uniprot_accession":"O94548","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf5427-pf10310.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10310","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf5427-pf10310.yaml"}],"pfam_ids":["PF10310"],"protein_name":"Maintenance of telomere capping protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSENKNSEAEDVFEFLDSLPEAKNGGKMVNTDVKGSQEGVKGGSNSVAGKTGNDGKKGDDDIFEFLEELEKSNLSLTDKKGVEKKAPSESVNNKAQDEKVEESKENKNSEQDAHGKEKEPQQQEKEEEEEEEEEEEEEEEETPLHDPIASISNWWSSSGSAKVSSIWNKTAEQASQIKNRLAQEQLDLTSKINTSTITEIARNLQKIVVGETEEVLRIHLVHDLVNYPSLQYNIESKFDQVLSSQVEGGIRIFVDEWGHPNNNGITPVEKKPSVADGELGNSKKKLQFNLFDGKVTDGEKLAFANLENAVKLFNTAHEEYQKQQKEADATPDDDRSSISSNSNKISDLFISILPIAIPQKQKDADGDFQVTDSNTPGNFNFTLVLKDITNDITTITRSQGFPVKWVNWLEGSVEKTGSTASEERNKSYDQKKQKESEDEDEDDEIIDPSEWVKEWIEDGLSLSFGVMAQNYVIDRMGL","sequence_length":478,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"11306fc4b6e4fe059207f00ad3eac9955ea3d7d07792c3e449dffdf259d60b8b","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P47018.json","taxon_id":"559292","uniprot_accession":"P47018","uniprot_release":"2026_03"}],"pfam_id":"PF10310","short_name":"DUF5427","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}