{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF10445","protein_label":"Uncharacterized protein C594.02c","reviewed":true,"short_name":"DUF2456","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2456-pf10445.yaml","source_record_id":"Pfam:PF10445","source_record_label":"Protein of unknown function (DUF2456)","source_section":"canonical_examples","taxon_id":"NCBITaxon:284812","taxon_label":"Schizosaccharomyces pombe (strain 972 / ATCC 24843)","uniprot_accession":"O74505","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF10445","protein_label":"Uncharacterized protein YHL026C","reviewed":true,"short_name":"DUF2456","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2456-pf10445.yaml","source_record_id":"Pfam:PF10445","source_record_label":"Protein of unknown function (DUF2456)","source_section":"canonical_examples","taxon_id":"NCBITaxon:559292","taxon_label":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","uniprot_accession":"P38740","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF10445","protein_label":"","reviewed":null,"short_name":"DUF2456","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2456-pf10445.yaml","source_record_id":"Pfam:PF10445","source_record_label":"Protein of unknown function (DUF2456)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":410,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":2,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is a family of uncharacterised proteins.","domain_architectures":8,"interpro_id":"IPR018852","known_evidence_count":null,"matches":491,"name":"Protein of unknown function (DUF2456)","partial_evidence_count":null,"pfam_id":"PF10445","proteins":491,"proteomes":454,"short_name":"DUF2456","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10445","structures":0,"taxa":917,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF10445.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":410,"domain_architectures":8,"matches":491,"proteins":491,"proteomes":454,"structures":0,"taxa":917},"curation_status":"SEEDED","description":"This is a family of uncharacterised proteins.","id":"Pfam:PF10445","interpro_id":"InterPro:IPR018852","name":"Protein of unknown function (DUF2456)","pfam_id":"PF10445","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF2456","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10445"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF10445.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"7e409c6f03041f15256c4104834f2d47af68f86ec02942d38ecb4d5e65588e32"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Schizosaccharomyces pombe (strain 972 / ATCC 24843)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2456-pf10445.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10445","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2456-pf10445.yaml"}],"pfam_ids":["PF10445"],"protein_name":"Uncharacterized protein C594.02c","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAPAVFTSDYWKKYFSNKKKPTVKNTSDIDLLHINRGRQPFDEGLSINEDSFFYRHNIHVPRIVYLIIVACGSFIITGGIEFAIAYGMYKKTETSVRLWRLPDTLSGDAAVTNFVQAIVTYWVESILVQGDLRSGLVKPIYFGWWPENFLLREVLRAKPRYHFKFIVFRWMEWLVFVGLRGLVWSVPLWFLFWPATVGILCAPGRHEGNDYYFNNYPAPQVFKLIFGGGEGFVLTPWIAFLHMYMYGHYLHVAKNQKSLPKTSDLEQQRGTSSSQPSENDANITALPKPEPKMYENSDLTPARTPVTPAPLEKPVNLAPEVVEPTNAAASPLQLNAPKLTDVDDSALAYDPTKVQDGEDRFVHNDVPLENAENPSRFVHSDAPIDMTHTTTVISEAQNLPSTLLPQDGNAVHHDTDAPSLSNVRKSVDSPRVPPSFSDDAVSSFSLVTAPSINNVGGSTAPSVNNQEREYDYDDTSSRSSTLTERPVVH","sequence_length":489,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"5f4319ccd1d9c4b5497b8e0e67eaa1e0df0f42ff0c0bb27559e42e56c4d8a343","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/O74505.json","taxon_id":"284812","uniprot_accession":"O74505","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2456-pf10445.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10445","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2456-pf10445.yaml"}],"pfam_ids":["PF10445"],"protein_name":"Uncharacterized protein YHL026C","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKSSEPAPATPTGFRNSIWFIIFYLFVIQALGSAIISGGIEFAIAYAMYHSRVDLITLWAFPHTISGDCALSLFIQVGLTWASEEILVGFDDYKRPVFRLNKWITKPSPLKTESNEEIPPPKKRFIVDYFESKDNVVAKQNTLYHKHNWLFGYLEVNRGIIPKGKEATLKGFLTSQFIHDSTQSKFMNFIEWFVQKFIRSMILAIAMFIVIWPVTMGILAGIGHKVGSHDYYFNDYPLPQVMKLIYAVVIAFVCTPVAIIVIVLRNQFHEELYYEGLANGTLQQDQEVCSTGNRSSGSTDQDISTTKQQSQEAVA","sequence_length":315,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"3363c6f70ab0813624f0d2af034a0627a1563c5250da630b2f0cd87f7fbe7b5e","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P38740.json","taxon_id":"559292","uniprot_accession":"P38740","uniprot_release":"2026_03"}],"pfam_id":"PF10445","short_name":"DUF2456","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}