{"cross_mech":[],"family":{"alphafold_models":385,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This protein family includes Protein YebY from Escherichia coli and similar proteins predominantly found in Gammaproteobacteria. YebY is a component of the AZY copper uptake system, where it functions as a negative regulator of the copper importer YebZ [[cite:PUB00163268]]. At high copper concentrations, YebY may act as a safety valve, preventing toxic copper overload by inhibiting the import activity of YebZ and YobA [[cite:PUB00163268]]. The reduced form of YebY binds Cu(+) and Cu(2+) with low affinity and shows low specificity, also binding Co(2+), Ni(2+), and Ag(+) [[cite:PUB00100157]]. However, the low affinity of copper binding, together with the stabilisation imparted by a disulphide bond, suggests that this metal binding is likely not physiologically relevant [[cite:PUB00100157]].","domain_architectures":4,"interpro_id":"IPR019648","known_evidence_count":null,"matches":649,"name":"Protein YebY","partial_evidence_count":null,"pfam_id":"PF10709","proteins":647,"proteomes":626,"short_name":"YebY","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10709","structures":3,"taxa":1011,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF10709.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":385,"domain_architectures":4,"matches":649,"proteins":647,"proteomes":626,"structures":3,"taxa":1011},"curation_status":"SEEDED","description":"This protein family includes Protein YebY from Escherichia coli and similar proteins predominantly found in Gammaproteobacteria. YebY is a component of the AZY copper uptake system, where it functions as a negative regulator of the copper importer YebZ [[cite:PUB00163268]]. At high copper concentrations, YebY may act as a safety valve, preventing toxic copper overload by inhibiting the import activity of YebZ and YobA [[cite:PUB00163268]]. The reduced form of YebY binds Cu(+) and Cu(2+) with low affinity and shows low specificity, also binding Co(2+), Ni(2+), and Ag(+) [[cite:PUB00100157]]. However, the low affinity of copper binding, together with the stabilisation imparted by a disulphide bond, suggests that this metal binding is likely not physiologically relevant [[cite:PUB00100157]].","id":"Pfam:PF10709","interpro_id":"InterPro:IPR019648","name":"Protein YebY","pfam_id":"PF10709","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"YebY","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10709"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF10709.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"8fb32fdc2e40c523bad8e35ff9fb5bdf13c28c91a3f7da757e2bfcd12b265e85"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/yeby-pf10709.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10709","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/yeby-pf10709.yaml"}],"pfam_ids":["PF10709"],"protein_name":"Protein YebY","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MMKKSILAFLLLTSSAAALAAPQVITVSRFEVGKDKWAFNREEVMLTCRPGNALYVINPSTLVQYPLNDIAQKEVASGKTNAQPISVIQIDDPNNPGEKMSLAPFIERAEKLC","sequence_length":113,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"c6e07e3c4ce493c28165d93a6e88710fb892844394a3170679d32045e5a57f9f","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P64506.json","taxon_id":"83333","uniprot_accession":"P64506","uniprot_release":"2026_03"}],"pfam_id":"PF10709","short_name":"YebY","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}