{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF10776","protein_label":"Trifunctional sesterterpene/triterpene/sesquarterpene synthase","reviewed":true,"short_name":"DUF2600","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2600-pf10776.yaml","source_record_id":"Pfam:PF10776","source_record_label":"Protein of unknown function (DUF2600)","source_section":"canonical_examples","taxon_id":"NCBITaxon:79880","taxon_label":"Shouchella clausii","uniprot_accession":"M5AW86","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF10776","protein_label":"Tetraprenyl-beta-curcumene synthase","reviewed":true,"short_name":"DUF2600","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2600-pf10776.yaml","source_record_id":"Pfam:PF10776","source_record_label":"Protein of unknown function (DUF2600)","source_section":"canonical_examples","taxon_id":"NCBITaxon:224308","taxon_label":"Bacillus subtilis (strain 168)","uniprot_accession":"O34707","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF10776","protein_label":"","reviewed":null,"short_name":"DUF2600","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2600-pf10776.yaml","source_record_id":"Pfam:PF10776","source_record_label":"Protein of unknown function (DUF2600)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":691,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":2,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is a bacterial family of proteins. Some members in the family are annotated as YtpB however currently no function is known.","domain_architectures":2,"interpro_id":"IPR019712","known_evidence_count":null,"matches":1119,"name":"Protein of unknown function (DUF2600)","partial_evidence_count":null,"pfam_id":"PF10776","proteins":1114,"proteomes":1073,"short_name":"DUF2600","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10776","structures":3,"taxa":1480,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF10776.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":691,"domain_architectures":2,"matches":1119,"proteins":1114,"proteomes":1073,"structures":3,"taxa":1480},"curation_status":"SEEDED","description":"This is a bacterial family of proteins. Some members in the family are annotated as YtpB however currently no function is known.","id":"Pfam:PF10776","interpro_id":"InterPro:IPR019712","name":"Protein of unknown function (DUF2600)","pfam_id":"PF10776","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF2600","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10776"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF10776.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"5f2bcdb20bf09397ce71873e8c611949c45cf7f12f778047113ac9168bde0392"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Shouchella clausii","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2600-pf10776.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10776","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2600-pf10776.yaml"}],"pfam_ids":["PF10776"],"protein_name":"Trifunctional sesterterpene/triterpene/sesquarterpene synthase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGTVPANPFKIIQLAFKETVPKAHAELQKWHQEALKIEDVEIREQAAWTVNDKTFHCEGGSIFALLAGENKDNHIQFLVAYQTICDYLDTLCDKNDAHDPNDFRSIHQALLDCLTPDKPYGDYYQYRDRFEDNGYLRKLVDACREATASFPGFADMQTHMQEVSQFYIDFQVYKHVEEEKREPLLKDFYERNKHFAPTMRWYEFACGTASTLALYCMAAYAAAPVQTAQGQQIKEAYFTWVQGVHILLDYFIDQEEDRQENEMNFVAYYRDSKEMFERFKYIDEKATEKLQMLPDKKFHLLLKTGLYALYLSDKKVMSHPRLKAEAKQLIKLGGFPASLFYYNRWIFKRKIS","sequence_length":352,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"8e41615c001e9c27625895b6306408ed6b64c42dc7fb5f83b134c5f767235eee","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/M5AW86.json","taxon_id":"79880","uniprot_accession":"M5AW86","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2600-pf10776.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10776","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2600-pf10776.yaml"}],"pfam_ids":["PF10776"],"protein_name":"Tetraprenyl-beta-curcumene synthase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTVPEHPFGLMAKVYRDIFPLVHQELDIWKQKSESIHNSELKAQATASIRDKTFHCEGGGILALLSGSQKQKCVEFIIAYQTISDYLDNLCDRSTSLDPQDFRMLHASMQDALTVGAELQNYYQFREEQDDSGYLHELVKTCQRVLGSIEHYDMIKPYLLELCGYYCDLQVHKHVIEHERVPRLEKWFTQYESELPEMEWYEFSACAGSTLGIFCLVAYSFQPDFTESTAKKIRDSYFPYIQGLHILLDYLIDQEEDLLEGDLNFCSYYQSHEEMMDRLEHFIHKADEHLQGIPHENFHRLINRGLLGVYLSDDKVAGQKEMGRLAKKLIKASGKTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC","sequence_length":367,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"691c0b228dce59df51c2264fad62d6850e100a7c16e1d6eaa9d13e9e52273aff","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/O34707.json","taxon_id":"224308","uniprot_accession":"O34707","uniprot_release":"2026_03"}],"pfam_id":"PF10776","short_name":"DUF2600","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}