{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF10802","protein_label":"Uncharacterized protein MJ0366","reviewed":true,"short_name":"DUF2540","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2540-pf10802.yaml","source_record_id":"Pfam:PF10802","source_record_label":"Protein of unknown function (DUF2540)","source_section":"canonical_examples","taxon_id":"NCBITaxon:243232","taxon_label":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","uniprot_accession":"Q57812","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF10802","protein_label":"","reviewed":null,"short_name":"DUF2540","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2540-pf10802.yaml","source_record_id":"Pfam:PF10802","source_record_label":"Protein of unknown function (DUF2540)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF10802","protein_label":"Uncharacterized protein MJ0366","reviewed":true,"short_name":"DUF2540","source_category":"sequence/homologous_superfamily/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/homologous_superfamily/interpro/ribbon-helix-helix-ipr010985.yaml","source_record_id":"InterPro:IPR010985","source_record_label":"Ribbon-helix-helix","source_section":"canonical_examples","taxon_id":"NCBITaxon:243232","taxon_label":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","uniprot_accession":"Q57812","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF10802","protein_label":"Uncharacterized protein MJ0366","reviewed":true,"short_name":"DUF2540","source_category":"structure/homologous_superfamily/cath","source_mech":"ProteinTraitsMech","source_path":"data/traits/structure/homologous_superfamily/cath/uncharacterised-protein-pf10802-duf2540-3-30-70-3260.yaml","source_record_id":"CATH:3.30.70.3260","source_record_label":"Uncharacterised protein PF10802, DUF2540","source_section":"canonical_examples","taxon_id":"NCBITaxon:243232","taxon_label":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","uniprot_accession":"Q57812","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":12,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":1,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":3},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family of proteins includes the uncharacterized protein MJ0366 from Methanocaldococcus jannaschii and similar proteins predominantly found in Methanococci. This protein adopts the 3-1 trefoil knot conformation [[cite:PUB00100668]].","domain_architectures":1,"interpro_id":"IPR024254","known_evidence_count":null,"matches":15,"name":"Protein of unknown function (DUF2540)","partial_evidence_count":null,"pfam_id":"PF10802","proteins":15,"proteomes":10,"short_name":"DUF2540","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10802","structures":1,"taxa":42,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF10802.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":12,"domain_architectures":1,"matches":15,"proteins":15,"proteomes":10,"structures":1,"taxa":42},"curation_status":"SEEDED","description":"This family of proteins includes the uncharacterized protein MJ0366 from Methanocaldococcus jannaschii and similar proteins predominantly found in Methanococci. This protein adopts the 3-1 trefoil knot conformation [[cite:PUB00100668]].","id":"Pfam:PF10802","interpro_id":"InterPro:IPR024254","name":"Protein of unknown function (DUF2540)","pfam_id":"PF10802","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF2540","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10802"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF10802.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"c5b922de0d2c3c2d0c39fe1c8a4a6a9f04ff39597b0f4a3b29c0d594284cbd45"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2540-pf10802.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10802","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2540-pf10802.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/ribbon-helix-helix-ipr010985.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR010985","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/ribbon-helix-helix-ipr010985.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/uncharacterised-protein-pf10802-duf2540-3-30-70-3260.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.30.70.3260","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/uncharacterised-protein-pf10802-duf2540-3-30-70-3260.yaml"}],"pfam_ids":["PF10802"],"protein_name":"Uncharacterized protein MJ0366","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MPLVGFMKEKKRATFYLYKNIDGRKLRYLLHKLENVENVDIDTLRRAIEAEKKYKRSITLTEEEEVIIQRLGKSANLLLNCELVKLDEGERA","sequence_length":92,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"a3629d4fe78a51a7dd1f4b562f21d51a654dcad9d3ea5d05cdbbbec3b6b0937d","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q57812.json","taxon_id":"243232","uniprot_accession":"Q57812","uniprot_release":"2026_03"}],"pfam_id":"PF10802","short_name":"DUF2540","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}