{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF10812","protein_label":"Uncharacterized protein MT2253","reviewed":true,"short_name":"DUF2561","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2561-pf10812.yaml","source_record_id":"Pfam:PF10812","source_record_label":"Protein of unknown function (DUF2561)","source_section":"canonical_examples","taxon_id":"NCBITaxon:83331","taxon_label":"Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)","uniprot_accession":"P9WLI8","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF10812","protein_label":"Uncharacterized protein Rv2197c","reviewed":true,"short_name":"DUF2561","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2561-pf10812.yaml","source_record_id":"Pfam:PF10812","source_record_label":"Protein of unknown function (DUF2561)","source_section":"canonical_examples","taxon_id":"NCBITaxon:83332","taxon_label":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)","uniprot_accession":"P9WLI9","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF10812","protein_label":"","reviewed":null,"short_name":"DUF2561","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2561-pf10812.yaml","source_record_id":"Pfam:PF10812","source_record_label":"Protein of unknown function (DUF2561)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":186,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":2,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family of proteins with unknown function appears to be restricted to Mycobacterium spp.","domain_architectures":2,"interpro_id":"IPR024381","known_evidence_count":null,"matches":249,"name":"Protein of unknown function (DUF2561)","partial_evidence_count":null,"pfam_id":"PF10812","proteins":248,"proteomes":248,"short_name":"DUF2561","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10812","structures":0,"taxa":279,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF10812.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":186,"domain_architectures":2,"matches":249,"proteins":248,"proteomes":248,"structures":0,"taxa":279},"curation_status":"SEEDED","description":"This family of proteins with unknown function appears to be restricted to Mycobacterium spp.","id":"Pfam:PF10812","interpro_id":"InterPro:IPR024381","name":"Protein of unknown function (DUF2561)","pfam_id":"PF10812","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF2561","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10812"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF10812.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"7e7dcf60fc6a7d2f6c15e405706d8ee5e1cf64331c9e6ed09c019af6111700ab"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2561-pf10812.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10812","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2561-pf10812.yaml"}],"pfam_ids":["PF10812"],"protein_name":"Uncharacterized protein MT2253","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MVSRYSAYRRGPDVISPDVIDRILVGACAAVWLVFTGVSVAAAVALMDLGRGFHEMAGNPHTTWVLYAVIVVSALVIVGAIPVLLRARRMAEAEPATRPTGASVRGGRSIGSGHPAKRAVAESAPVQHADAFEVAAEWSSEAVDRIWLRGTVVLTSAIGIALIAVAAATYLMAVGHDGPSWISYGLAGVVTAGMPVIEWLYARQLRRVVAPQSS","sequence_length":214,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"29e68a6bff348655f5b2a38e4b7b0cd1c07157fcc24364f94e816c028fdfad1f","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P9WLI8.json","taxon_id":"83331","uniprot_accession":"P9WLI8","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2561-pf10812.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10812","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2561-pf10812.yaml"}],"pfam_ids":["PF10812"],"protein_name":"Uncharacterized protein Rv2197c","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MVSRYSAYRRGPDVISPDVIDRILVGACAAVWLVFTGVSVAAAVALMDLGRGFHEMAGNPHTTWVLYAVIVVSALVIVGAIPVLLRARRMAEAEPATRPTGASVRGGRSIGSGHPAKRAVAESAPVQHADAFEVAAEWSSEAVDRIWLRGTVVLTSAIGIALIAVAAATYLMAVGHDGPSWISYGLAGVVTAGMPVIEWLYARQLRRVVAPQSS","sequence_length":214,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"29e68a6bff348655f5b2a38e4b7b0cd1c07157fcc24364f94e816c028fdfad1f","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P9WLI9.json","taxon_id":"83332","uniprot_accession":"P9WLI9","uniprot_release":"2026_03"}],"pfam_id":"PF10812","short_name":"DUF2561","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}