{"cross_mech":[],"family":{"alphafold_models":186,"candidate_reasons":["description_says_unknown_function","domain_of_unknown_function","pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"Proteins in this family have a HotDog fold. This family was formerly known as domain of unknown function 2662 (DUF2662). The structure of Rv0098 from M. tuberculosis [[cite:PUB00048671]] suggested a thioesterase function. Assays showed that this protein was a thioesterase with a preference for long chain fatty acyl groups [[cite:PUB00048671]]. The maximal Kcat was observed for palmitoyl-CoA although longer and shorter molecules were also cleaved. In solution this protein forms a homo-hexameric complex.","domain_architectures":2,"interpro_id":"IPR022598","known_evidence_count":null,"matches":298,"name":"FcoT-like thioesterase domain","partial_evidence_count":null,"pfam_id":"PF10862","proteins":298,"proteomes":264,"short_name":"FcoT","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10862","structures":4,"taxa":450,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF10862.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":186,"domain_architectures":2,"matches":298,"proteins":298,"proteomes":264,"structures":4,"taxa":450},"curation_status":"SEEDED","description":"Proteins in this family have a HotDog fold. This family was formerly known as domain of unknown function 2662 (DUF2662). The structure of Rv0098 from M. tuberculosis [[cite:PUB00048671]] suggested a thioesterase function. Assays showed that this protein was a thioesterase with a preference for long chain fatty acyl groups [[cite:PUB00048671]]. The maximal Kcat was observed for palmitoyl-CoA although longer and shorter molecules were also cleaved. In solution this protein forms a homo-hexameric complex.","id":"Pfam:PF10862","interpro_id":"InterPro:IPR022598","name":"FcoT-like thioesterase domain","pfam_id":"PF10862","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"FcoT","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10862"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF10862.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"43aaad6fba7cd23c9c7c0bce8dcaa9c733b94a714283e77fa2124d47f2061fe3"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycobacterium marinum (strain ATCC BAA-535 / M)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/fcot-pf10862.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10862","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/fcot-pf10862.yaml"}],"pfam_ids":["PF10862"],"protein_name":"(2E)-enoyl-[ACP] glycyltransferase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSTTDLTSPAHAAVESAGTTAIAEDLLARVLEPYSYKGCRYLLDARYHADDDSVLAYGNFTISESAYIRSTGHFNAVELILCFNQLAYSAFAPAVANEEIPQLRGWSLEDYFQHQLASMFIRNSSSRFNRPINPAKFSARLQCRNLQVVQRTWRYLLVPCAIEFWDEDGGAASGEVELAALNIP","sequence_length":184,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"51862de7b7fbae968fe5627163361e6d3d16449b8b9b272b3f26b9561f01cbe2","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/B2HKM2.json","taxon_id":"216594","uniprot_accession":"B2HKM2","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/fcot-pf10862.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10862","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/fcot-pf10862.yaml"}],"pfam_ids":["PF10862"],"protein_name":"(2E)-enoyl-[ACP] glycyltransferase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSHTDLTPCTRVLASSGTVPIAEELLARVLEPYSCKGCRYLIDAQYSATEDSVLAYGNFTIGESAYIRSTGHFNAVELILCFNQLAYSAFAPAVLNEEIRVLRGWSIDDYCQHQLSSMLIRKASSRFRKPLNPQKFSARLLCRDLQVIERTWRYLKVPCVIEFWDENGGAASGEIELAALNIP","sequence_length":183,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"d421e40f3a85a4e5bc3292f3f4432cd82de00731de1ca85b1c121410ba531aff","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P9WM66.json","taxon_id":"83331","uniprot_accession":"P9WM66","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/fcot-pf10862.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10862","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/fcot-pf10862.yaml"}],"pfam_ids":["PF10862"],"protein_name":"(2E)-enoyl-[ACP] glycyltransferase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSHTDLTPCTRVLASSGTVPIAEELLARVLEPYSCKGCRYLIDAQYSATEDSVLAYGNFTIGESAYIRSTGHFNAVELILCFNQLAYSAFAPAVLNEEIRVLRGWSIDDYCQHQLSSMLIRKASSRFRKPLNPQKFSARLLCRDLQVIERTWRYLKVPCVIEFWDENGGAASGEIELAALNIP","sequence_length":183,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"d421e40f3a85a4e5bc3292f3f4432cd82de00731de1ca85b1c121410ba531aff","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P9WM67.json","taxon_id":"83332","uniprot_accession":"P9WM67","uniprot_release":"2026_03"}],"pfam_id":"PF10862","short_name":"FcoT","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
