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Through biochemical studies, it was shown that this protein co purifies with the oxoglutarate dehydrogenase complex (OGDC). Both mitochondrial ribosome 28S subunit and OGDC have a similar size and OGDC is highly abundant, being found to contaminate ribosomal preparations [[cite:PUB00089008]]. Kgd4 plays an evolutionarily conserved role in the organisation of mitochondrial alpha-KGDH complexes of fungi and animals which constitutes a molecular adaptor that is necessary to form a stable alpha-KGDH enzyme complex [[cite:PUB00089008],[cite:PUB00100356]].","id":"Pfam:PF10937","interpro_id":"InterPro:IPR020373","name":"Alpha-ketoglutarate dehydrogenase component 4/YMR-31","pfam_id":"PF10937","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Kgd4-YMR31","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10937"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF10937.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"3f5439a8cbcb62ee84aea6ecdcb1479dabccbc04b12ddb369feb69f956e55505"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Schizosaccharomyces pombe (strain 972 / ATCC 24843)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/kgd4-ymr31-pf10937.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10937","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/kgd4-ymr31-pf10937.yaml"}],"pfam_ids":["PF10937"],"protein_name":"Alpha-ketoglutarate dehydrogenase subunit 4, mitochondrial","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MVRKILIDFTKHITKSSLERHPHPAASFPLPASFTTVDSGPAKHSTAPPATPETSILVEDRNELPLRFHRLPVSEAEMQAVESGGAYAF","sequence_length":89,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"8aa5e7c6fc098fd5837394353393ed63edd4dc014a6b66fe1ce258255899a7bf","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/G2TRP3.json","taxon_id":"284812","uniprot_accession":"G2TRP3","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/kgd4-ymr31-pf10937.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10937","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/kgd4-ymr31-pf10937.yaml"}],"pfam_ids":["PF10937"],"protein_name":"Alpha-ketoglutarate dehydrogenase subunit 4, mitochondrial","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MIATPIRLAKSAYEPMIKFVGTRHPLVKHATEVVVHPCATNGMLPGSKECIPVSKFMENYKPFRVVPIKHSANAGLSSSKTSVFVNRPLQKDELASIFELPARFRYKPINEHELESINSGGAW","sequence_length":123,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"5751aacd9f5a9db77e0d3e85a5fb5edaf782fcbe0f852f2a192a2628f782da50","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P19955.json","taxon_id":"559292","uniprot_accession":"P19955","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/kgd4-ymr31-pf10937.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10937","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/kgd4-ymr31-pf10937.yaml"}],"pfam_ids":["PF10937"],"protein_name":"Alpha-ketoglutarate dehydrogenase component 4","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGSKMASATRVVQVVKPHAPLIKFPNRRDKPKLSASEALGSAALPSHSSAISQHSKGSTSPDLLMHQGPPDTAEIIKSLPQKYRRKPMSQEEMEFIQRGGPE","sequence_length":102,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"45cfea00399a023c1c343e96816cc2caa7384530004603a62a311fbfb6025144","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9CQX8.json","taxon_id":"10090","uniprot_accession":"Q9CQX8","uniprot_release":"2026_03"}],"pfam_id":"PF10937","short_name":"Kgd4-YMR31","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}