{"cross_mech":[],"family":{"alphafold_models":389,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"Cellulose is necessary for biofilm formation in bacteria and is synthesized by the bacterial cellulose biosynthesis complex (Bcs) which is widespread among beta and gamma proteobacteria [[cite:PUB00075887],[cite:PUB00105928]]. CBP_BcsR is a small subunit of this complex, essential for cellulose secretion [[cite:PUB00105928]]. It may play a regulatory role together with BcsQ subunit as they form a subcomplex with chaperone-like function toward each other [[cite:PUB00151583]]. BcsR stabilizes BcsQ to form monodisperse BcsR2Q2 heterotetramers in solution and BcsQ may play a role in the folding and subsequent stability of BcsR [[cite:PUB00151583]].","domain_architectures":2,"interpro_id":"IPR024487","known_evidence_count":null,"matches":624,"name":"Cellulose biosynthesis protein BcsR-like","partial_evidence_count":null,"pfam_id":"PF10945","proteins":624,"proteomes":606,"short_name":"CBP_BcsR","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10945","structures":9,"taxa":847,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF10945.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":389,"domain_architectures":2,"matches":624,"proteins":624,"proteomes":606,"structures":9,"taxa":847},"curation_status":"SEEDED","description":"Cellulose is necessary for biofilm formation in bacteria and is synthesized by the bacterial cellulose biosynthesis complex (Bcs) which is widespread among beta and gamma proteobacteria [[cite:PUB00075887],[cite:PUB00105928]]. CBP_BcsR is a small subunit of this complex, essential for cellulose secretion [[cite:PUB00105928]]. It may play a regulatory role together with BcsQ subunit as they form a subcomplex with chaperone-like function toward each other [[cite:PUB00151583]]. BcsR stabilizes BcsQ to form monodisperse BcsR2Q2 heterotetramers in solution and BcsQ may play a role in the folding and subsequent stability of BcsR [[cite:PUB00151583]].","id":"Pfam:PF10945","interpro_id":"InterPro:IPR024487","name":"Cellulose biosynthesis protein BcsR-like","pfam_id":"PF10945","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"CBP_BcsR","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10945"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF10945.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"2f4f5709fb500efe7341c808ff5174d86b77df625b666c49b86a7c3eaa79f0e2"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/bacterial-cellulose-biosynthetic-process-go0090540.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0090540","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/bacterial-cellulose-biosynthetic-process-go0090540.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/cellulose-biosynthesis-protein-bcsr-nf040717.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF040717","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/cellulose-biosynthesis-protein-bcsr-nf040717.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/cbp-bcsr-pf10945.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10945","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/cbp-bcsr-pf10945.yaml"}],"pfam_ids":["PF10945"],"protein_name":"Protein YhjR","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNNNEPDTLPDPAIGYIFQNDIVALKQAFSLPDIDYADISQREQLAAALKRWPLLAEFAQQK","sequence_length":62,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"9a6e39cba993ae89363029bbdaf250d61bf23ff3e0580f55398163af75103ca1","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P0ADJ3.json","taxon_id":"83333","uniprot_accession":"P0ADJ3","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Shigella flexneri","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/cbp-bcsr-pf10945.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10945","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/cbp-bcsr-pf10945.yaml"}],"pfam_ids":["PF10945"],"protein_name":"Protein YhjR","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNNNEPDTLPDPAIGYIFQNDIVALKQAFSLPDIDYADISQREQLAAALKRWPLLAEFAQQK","sequence_length":62,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"9a6e39cba993ae89363029bbdaf250d61bf23ff3e0580f55398163af75103ca1","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P0ADJ4.json","taxon_id":"623","uniprot_accession":"P0ADJ4","uniprot_release":"2026_03"}],"pfam_id":"PF10945","short_name":"CBP_BcsR","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}