{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF10956","protein_label":"Uncharacterized protein YhhA","reviewed":true,"short_name":"DUF2756","source_category":"function/protein_family/ncbifam","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/protein_family/ncbifam/duf2756-family-protein-nf007675.yaml","source_record_id":"NCBIfam:NF007675","source_record_label":"DUF2756 family protein","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P0ADX7","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF10956","protein_label":"Uncharacterized protein YhhA","reviewed":true,"short_name":"DUF2756","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2756-pf10956.yaml","source_record_id":"Pfam:PF10956","source_record_label":"Protein of unknown function (DUF2756)","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P0ADX7","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF10956","protein_label":"Uncharacterized protein YhhA","reviewed":true,"short_name":"DUF2756","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2756-pf10956.yaml","source_record_id":"Pfam:PF10956","source_record_label":"Protein of unknown function (DUF2756)","source_section":"canonical_examples","taxon_id":"NCBITaxon:623","taxon_label":"Shigella flexneri","uniprot_accession":"P0ADX8","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF10956","protein_label":"","reviewed":null,"short_name":"DUF2756","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf2756-pf10956.yaml","source_record_id":"Pfam:PF10956","source_record_label":"Protein of unknown function (DUF2756)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":184,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":2,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":2},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"Some members in this family of proteins are annotated yhhA however currently no function is known. The family appears to be restricted to Enterobacteriaceae.","domain_architectures":2,"interpro_id":"IPR020158","known_evidence_count":null,"matches":297,"name":"Protein of unknown function (DUF2756)","partial_evidence_count":null,"pfam_id":"PF10956","proteins":297,"proteomes":297,"short_name":"DUF2756","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10956","structures":0,"taxa":434,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF10956.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":184,"domain_architectures":2,"matches":297,"proteins":297,"proteomes":297,"structures":0,"taxa":434},"curation_status":"SEEDED","description":"Some members in this family of proteins are annotated yhhA however currently no function is known. The family appears to be restricted to Enterobacteriaceae.","id":"Pfam:PF10956","interpro_id":"InterPro:IPR020158","name":"Protein of unknown function (DUF2756)","pfam_id":"PF10956","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF2756","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10956"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF10956.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"df9460a68140f004020b2e5e4218a66e660ab1a78da6f74570317a57b4d3a320"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/duf2756-family-protein-nf007675.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF007675","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/duf2756-family-protein-nf007675.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2756-pf10956.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10956","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2756-pf10956.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P0ADX7","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF10956"],"protein_name":"Uncharacterized protein YhhA","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"03710c306e37cde11f60565aac11ee495daa369372a1cd3096f2794355bb67c2","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MKRLLILTALLPFVGFAQPINTLNNPNQPGYQIPSQQRMQTQMQTQQIQQKGMLNQQLKTQTQLQQQHLENQINNNSQRVLQSQPGERNPARQQMLPNTNGGMLNSNRNPDSSLNQQHMLPERRNGDMLNQPSTPQPDIPLKTIGP","sequence_length":146,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"03710c306e37cde11f60565aac11ee495daa369372a1cd3096f2794355bb67c2","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P0ADX7.json","taxon_id":"83333","uniprot_accession":"P0ADX7","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Shigella flexneri","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf2756-pf10956.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF10956","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf2756-pf10956.yaml"}],"pfam_ids":["PF10956"],"protein_name":"Uncharacterized protein YhhA","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKRLLILTALLPFVGFAQPINTLNNPNQPGYQIPSQQRMQTQMQTQQIQQKGMLNQQLKTQTQLQQQHLENQINNNSQRVLQSQPGERNPARQQMLPNTNGGMLNSNRNPDSSLNQQHMLPERRNGDMLNQPSTPQPDIPLKTIGP","sequence_length":146,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"03710c306e37cde11f60565aac11ee495daa369372a1cd3096f2794355bb67c2","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P0ADX8.json","taxon_id":"623","uniprot_accession":"P0ADX8","uniprot_release":"2026_03"}],"pfam_id":"PF10956","short_name":"DUF2756","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}