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Cellulose production in enterobacteria is controlled by a two-tiered c-di-GMP-dependent system involving BcsE and the PilZ domain containing glycosyltransferase BcsA [[cite:PUB00086880],[cite:PUB00075887],[cite:PUB00100649],[cite:PUB00100650],[cite:PUB00100648]]. This domain forms a membrane-proximal head-to-head dimer of P-loop nucleotide NTPase-like modules [[cite:PUB00163548]].","domain_architectures":4,"interpro_id":"IPR063588","known_evidence_count":null,"matches":605,"name":"Cellulose biosynthesis protein BcsE, N-terminal domain","partial_evidence_count":null,"pfam_id":"PF10995","proteins":604,"proteomes":594,"short_name":"BcsE_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF10995","structures":4,"taxa":869,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF10995.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":326,"domain_architectures":4,"matches":605,"proteins":604,"proteomes":594,"structures":4,"taxa":869},"curation_status":"SEEDED","description":"This entry includes members involved in cellulose biosynthesis such as BcsE proteins found in Salmonella typhimurium. They consist of a N-terminal NTPase catalytically incompetent nucleoside triphosphatase domain followed by a REC (phosphorylation-incompetent receiver domain) and a C-terminal GGDEF (degenerate diguanylate cyclase domain). The REC and GGDEF domains were firstly described as the GIL domain [[cite:PUB00100649],[cite:PUB00163548]]. BcsE proteins are not essential for cellulose synthesis but is critical for maximal cellulose production. Cellulose production in enterobacteria is controlled by a two-tiered c-di-GMP-dependent system involving BcsE and the PilZ domain containing glycosyltransferase BcsA [[cite:PUB00086880],[cite:PUB00075887],[cite:PUB00100649],[cite:PUB00100650],[cite:PUB00100648]]. This domain forms a membrane-proximal head-to-head dimer of P-loop nucleotide NTPase-like modules [[cite:PUB00163548]].","id":"Pfam:PF10995","interpro_id":"InterPro:IPR063588","name":"Cellulose biosynthesis protein BcsE, N-terminal 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