{"cross_mech":[],"family":{"alphafold_models":1429,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents mitochondrial proteins from fungi, such as subtelomeric hrmA-associated cluster protein AFUB_079030 from Aspergillus fumigatus and YDR124W from yeast. Null mutant showed severe fragmentation of mitochondria and its expression is strongly induced by alpha factor. These proteins may have a role in maintenance of mitochondrial morphology [[cite:PUB00101836]]. This entry represents an helical bundle domain which seems to adopt a similar arrangement than the EIN3-like DNA-binding domain (Based on structural comparison, DALI server). AFUB_079030 is part of the subtelomeric hrmA-associated cluster (HAC) containing genes that alter the hyphal surface (such as reduced total chitin or increased beta-glucan exposure) and perturb inter-hyphal interactions within the developing biofilms, resulting in a loss of vertically aligned polarised growing filaments [[cite:PUB00153731]].","domain_architectures":26,"interpro_id":"IPR047092","known_evidence_count":null,"matches":1722,"name":"YDR124W-like, helical bundle domain","partial_evidence_count":null,"pfam_id":"PF11001","proteins":1718,"proteomes":1067,"short_name":"AFUB_07903_YDR124W_hel","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11001","structures":0,"taxa":2117,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF11001.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1429,"domain_architectures":26,"matches":1722,"proteins":1718,"proteomes":1067,"structures":0,"taxa":2117},"curation_status":"SEEDED","description":"This entry represents mitochondrial proteins from fungi, such as subtelomeric hrmA-associated cluster protein AFUB_079030 from Aspergillus fumigatus and YDR124W from yeast. Null mutant showed severe fragmentation of mitochondria and its expression is strongly induced by alpha factor. These proteins may have a role in maintenance of mitochondrial morphology [[cite:PUB00101836]]. This entry represents an helical bundle domain which seems to adopt a similar arrangement than the EIN3-like DNA-binding domain (Based on structural comparison, DALI server). AFUB_079030 is part of the subtelomeric hrmA-associated cluster (HAC) containing genes that alter the hyphal surface (such as reduced total chitin or increased beta-glucan exposure) and perturb inter-hyphal interactions within the developing biofilms, resulting in a loss of vertically aligned polarised growing filaments [[cite:PUB00153731]].","id":"Pfam:PF11001","interpro_id":"InterPro:IPR047092","name":"YDR124W-like, helical bundle domain","pfam_id":"PF11001","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"AFUB_07903_YDR124W_hel","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11001"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF11001.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"3ce923f9ed74f5c39c6dd2bef9b9d7214fe7302b2b3f16d84ff9b6099fcd11b6"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/afub-07903-ydr124w-hel-pf11001.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11001","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/afub-07903-ydr124w-hel-pf11001.yaml"}],"pfam_ids":["PF11001"],"protein_name":"Subtelomeric hrmA-associated cluster protein AFUB_079030","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGLCVRSSINIPYFHYAMIYLDNMGRLKVMESPSIQEQNETVFTTEVRERFLEILGAKVGYQPPMVRSIYDPQQPLGCLSYRQTKRDRNSPAHSMYGVPPSVQFSAPVEESPSCGSVDMVGLEIGDTPNVLDYYERSLKHFRQVNCRQILKTFIKFIEPRKQAKHPYNGGKPPAGAPPGKKGDPEKTKPEWWPANVVHKEPDHLRKDRTCNPSENLQCQVTLLTDLERLSLLIHIIRRLGRFGITTDQLQEIAHDCKRRLSDPHKLQILDEVFRVRRIEERYERGEVDANKIVYVVNRESNQKEKDGDSNVDPDQKHEQEDDNAREALPILHSEKNSTSPMSNSAEHTGMAAPSRPMNMGGDRNQLFPLPEWPSFGETPQDDRIFFPTTSKYTEDYASQQMPRTPATTALVSTNETHAAFDYMTQESITSSSPEQTSHHRQAPLPMQHSASLDPWTPTFRHNFFNPMVYSTAPRHAMSQATMLSQFPRSTTSHGQEMPHMAHGLPNLPQDRPSSMDGMSMRGPSFRTGFLSHPCDPSQQAPHSSGCGHPDSWTQNRPHV","sequence_length":559,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"989231cb7b404017ea6319e866e3df7d4d8bcb561549c6a838449e80b0e76d03","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/B0Y8Y9.json","taxon_id":"451804","uniprot_accession":"B0Y8Y9","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/subtelomeric-hrma-associated-cluster-protein-afub-079030-ydr124w-like--ipr047092.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR047092","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/subtelomeric-hrma-associated-cluster-protein-afub-079030-ydr124w-like--ipr047092.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/ydr124w-n-terminal-domain-ipr048462.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR048462","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/ydr124w-n-terminal-domain-ipr048462.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/afub-07903-ydr124w-hel-pf11001.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11001","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/afub-07903-ydr124w-hel-pf11001.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/ydr124w-n-pf21652.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF21652","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/ydr124w-n-pf21652.yaml"}],"pfam_ids":["PF11001","PF21652"],"protein_name":"Uncharacterized protein YDR124W","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRIGMEELRRALALLNGQGYEFMVFIKEKDHLISESIPKNLFSESFISSSIEKNPPLTFDPLVNRKRITVYEENIQPAIMLPLDQPLLIQNYLYTAFKLLRQVPCKAIAKLWIKIIEPRKKTRFPYIKGNAGRPEWWPKDVEHKEPDHLQKADRLKLMCTIIMNVLPQSPFSLEILDELTGVTAAMTIFKKETVKKVIMKNVFEIAKCLCNKDFKQKTISLDDLNDLAQKQKKSYHSRRFDVNKMVKVEKDLLQQSSGSDSSPSMILPSKESDTEYFPREYPKDPVSEDYSNSISRLENLVEFDPLFLTKLDELTSSDDCKDFI","sequence_length":324,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"a51c594282c28c373f57ef6f1b8fcbb4077acdee3054de746a9408225b89a200","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q04608.json","taxon_id":"559292","uniprot_accession":"Q04608","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/afub-07903-ydr124w-hel-pf11001.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11001","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/afub-07903-ydr124w-hel-pf11001.yaml"}],"pfam_ids":["PF11001"],"protein_name":"Subtelomeric hrmA-associated cluster protein AFUA_5G14920","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGLCVRSSINIPYFHYAMIYLDNMGRLKVMESPSIQEQNETVFTTEVRERFLEILGAKVGYQPPMVRSIYDPQQPLGCLSYRQTKRDRNSPAHSMYGVPPSVQFSAPVEESPSCGSVDMVGLEIGDTPNVLDYYERSLKHFRQVNCRQILKTFIKFIEPRKQAKHPYNGGKPPAGAPPGKKGDPEKTKPEWWPANVVHKEPDHLRKDRTCNPSENLQCQVTLLTDLERLSLLIHIIRRLGRFGITTDQLQEIAHDCKRRLSDPHKLQILDEVFRVRRIEERYERGEVDANKIVYVVNRESNQKEKDGDSNVDPDQKHEQEDDNAREALPILHSEKNSTSPMSNSAEHTGMAAPSRPMNMGGDRNQLFPLPEWPSFGETPQDDRIFFPTTSKYTEDYASQQMPRTPATTALVSTNETHAAFDYMTQESITSSSPEQTSHHRQAPLPMQHSASLDPWTPTFRHNFFNPMVYSTAPRHAMSQATMLSQFPRSTTSHGQEMPHMAHGLPNLPQDRPSSMDGMSMRGPSFRTGFLSHPCDPSQQAPHSSGCGHPDSWTQNRPHV","sequence_length":559,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"989231cb7b404017ea6319e866e3df7d4d8bcb561549c6a838449e80b0e76d03","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q4WW99.json","taxon_id":"330879","uniprot_accession":"Q4WW99","uniprot_release":"2026_03"}],"pfam_id":"PF11001","short_name":"AFUB_07903_YDR124W_hel","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}