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L4-22K plays a role in genome packaging via its binding, in association with IVa2, to the A2 sequence within the packaging signal [[cite:PUB00076402]]. 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The L4 region expresses L4-33K and a related protein, L4-22K [[cite:PUB00076403]]. L4-22K and L4-33K have complementary but not redundant functions that provide the normal pattern of mRNA production during the late phase of infection [[cite:PUB00076403]]. L4-33K is an alternative RNA splicing factor that up-regulates several MLTU splice acceptor sites as the late phase progresses [[cite:PUB00076403],[cite:PUB00076401]]. L4-22K plays a role in genome packaging via its binding, in association with IVa2, to the A2 sequence within the packaging signal [[cite:PUB00076402]]. Additionally, L4-22K plays an important role in the temporal switch from the early to late phase of infection by regulating both early and late gene expression [[cite:PUB00076404],[cite:PUB00144935]].","id":"Pfam:PF11081","interpro_id":"InterPro:IPR021304","name":"Adenovirus 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