{"cross_mech":[],"family":{"alphafold_models":3515,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"Family members include Cryptococcus neoformans HVA1 (hypervirulence-associated protein 1) whose absence is associated with a hypervirulent phenotype in mice. Metabolomics analysis suggests that when HVA1 is absent there is a block in the citric acid cycle, while structural analysis of the Hva1 protein suggests a potential interaction with NADPH. The structural architecture of Hva1 bears similarity with Tudor domains [[cite:PUB00091033]].","domain_architectures":48,"interpro_id":"IPR021331","known_evidence_count":null,"matches":5242,"name":"Hypervirulence associated proteins TUDOR domain","partial_evidence_count":null,"pfam_id":"PF11160","proteins":5238,"proteomes":4414,"short_name":"Hva1_TUDOR","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11160","structures":1,"taxa":7010,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF11160.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3515,"domain_architectures":48,"matches":5242,"proteins":5238,"proteomes":4414,"structures":1,"taxa":7010},"curation_status":"SEEDED","description":"Family members include Cryptococcus neoformans HVA1 (hypervirulence-associated protein 1) whose absence is associated with a hypervirulent phenotype in mice. Metabolomics analysis suggests that when HVA1 is absent there is a block in the citric acid cycle, while structural analysis of the Hva1 protein suggests a potential interaction with NADPH. The structural architecture of Hva1 bears similarity with Tudor domains [[cite:PUB00091033]].","id":"Pfam:PF11160","interpro_id":"InterPro:IPR021331","name":"Hypervirulence associated proteins TUDOR domain","pfam_id":"PF11160","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Hva1_TUDOR","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11160"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF11160.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"562daf75f44e5110e950ff5e050169af2e603fa7bc5a124de23bd77b5a32c304"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Cryptococcus neoformans (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/hva1-tudor-pf11160.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11160","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/hva1-tudor-pf11160.yaml"}],"pfam_ids":["PF11160"],"protein_name":"Putative primary metabolism protein HVA1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSVQDKQGQNINVGDTVYTPYRGGKHEGQVADIVTTKEEAAEKGVKNPPKVLFTDQNNKDVAHNPGTLTDLDKQK","sequence_length":75,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"86696ec89bcaef7b15a612ab56c20fa6c8b1a6566741b64f2f6f747579d62abf","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/J9VKY2.json","taxon_id":"235443","uniprot_accession":"J9VKY2","uniprot_release":"2026_03"}],"pfam_id":"PF11160","short_name":"Hva1_TUDOR","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}