{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF11306","protein_label":"","reviewed":null,"short_name":"DUF3108","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf3108-pf11306.yaml","source_record_id":"Pfam:PF11306","source_record_label":"Protein of unknown function (DUF3108)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":5141,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":true,"records_by_mech":{},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is a bacterial family of putative lipoproteins. The structure for [swissprot:Q64U78], PDB:3fzx, the first structural template for this large family including several homologues in the human gut microbiome and in metagenomic datasets, folds into a beta barrel that topologically looks like a small-scale porin (such as FepA). [swissprot:Q64U78] is a putative exported protein, and this fold is of the YmcC-like type, with a predicted signal peptide SpI cleavage site AGAMA|QNQDC, and a Phobius server prediction of non-cytoplasmic localisation for amino acids 21-236. The possibility of it being a membrane protein can be ruled out by the hydrophilic nature of the solvent exposed surface outside the barrels. Analysis of sequence conservation suggests that an area near Glu172/Trp206 is potentially interesting. These two residues are also conserved in Dali hit PDB:2in5, a hypothetical lipoprotein classified as a new YmcC-like fold in SCOP (SCOP:159271, with a 12-stranded meander beta-sheet folded into a deformed beta-barrel) despite large structural differences between the two structures, suggesting similarity in function.","domain_architectures":10,"interpro_id":"IPR021457","known_evidence_count":null,"matches":8049,"name":"Protein of unknown function (DUF3108)","partial_evidence_count":null,"pfam_id":"PF11306","proteins":8047,"proteomes":6575,"short_name":"DUF3108","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11306","structures":0,"taxa":9208,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF11306.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":5141,"domain_architectures":10,"matches":8049,"proteins":8047,"proteomes":6575,"structures":0,"taxa":9208},"curation_status":"SEEDED","description":"This is a bacterial family of putative lipoproteins. The structure for [swissprot:Q64U78], PDB:3fzx, the first structural template for this large family including several homologues in the human gut microbiome and in metagenomic datasets, folds into a beta barrel that topologically looks like a small-scale porin (such as FepA). [swissprot:Q64U78] is a putative exported protein, and this fold is of the YmcC-like type, with a predicted signal peptide SpI cleavage site AGAMA|QNQDC, and a Phobius server prediction of non-cytoplasmic localisation for amino acids 21-236. The possibility of it being a membrane protein can be ruled out by the hydrophilic nature of the solvent exposed surface outside the barrels. Analysis of sequence conservation suggests that an area near Glu172/Trp206 is potentially interesting. These two residues are also conserved in Dali hit PDB:2in5, a hypothetical lipoprotein classified as a new YmcC-like fold in SCOP (SCOP:159271, with a 12-stranded meander beta-sheet folded into a deformed beta-barrel) despite large structural differences between the two structures, suggesting similarity in function.","id":"Pfam:PF11306","interpro_id":"InterPro:IPR021457","name":"Protein of unknown function (DUF3108)","pfam_id":"PF11306","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF3108","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11306"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF11306.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"475321264833226f59fed7a5a2fe340257a3050a05084575dc859c6a3498fb54"}},"protein_examples":{"candidate_count":0,"discovery_scanned":true,"example_count":0,"examples":[],"pfam_id":"PF11306","short_name":"DUF3108","status":"NO_SIBLING_CANDIDATE","unresolved":[]}}