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However, Fis1 and Caf4, but not Mdv1, determine the polar localization of Dnm1 clusters on the mitochondrial surface [[cite:PUB00074937]].","domain_architectures":3,"interpro_id":"IPR021653","known_evidence_count":null,"matches":17,"name":"CCR4-associated factor 4","partial_evidence_count":null,"pfam_id":"PF11615","proteins":17,"proteomes":15,"short_name":"Caf4","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11615","structures":1,"taxa":51,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF11615.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":14,"domain_architectures":3,"matches":17,"proteins":17,"proteomes":15,"structures":1,"taxa":51},"curation_status":"SEEDED","description":"Caf4 is a WD40 repeats containing protein involved in mitochondrial fission. It displays physical interactions with CCR4-NOT complex [[cite:PUB00053527]]. It has a paralogue, Mdv1. Both Caf4 and Mdv1 act as adapter proteins, binding to Fis1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase Dnm1 to form mitochondrial fission complexes [[cite:PUB00053320]]. However, Fis1 and Caf4, but not Mdv1, determine the polar localization of Dnm1 clusters on the mitochondrial surface [[cite:PUB00074937]].","id":"Pfam:PF11615","interpro_id":"InterPro:IPR021653","name":"CCR4-associated factor 4","pfam_id":"PF11615","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Caf4","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11615"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF11615.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"e921cb6644e4754a2083ee0b6737baea75ca98ae02724025b610dcb943f0520d"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain YJM789)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/caf4-pf11615.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11615","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/caf4-pf11615.yaml"}],"pfam_ids":["PF00400","PF11615"],"protein_name":"CCR4-associated factor 4","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGSGDTRGESSLVAKPIEIILNKLPHAILAQQQFQKYITSPIYRYLSKLLLFREVAWPESTKDTQKGQVGIFSFQNNYADSATTFRILAHLDEQRYPLPNGAAEKNLPSLFEGFKATVSIIQQRLLLDNVDGATNSDKEKYVQLPDINTGFVNKTYSRIDLTHLLEDVETNVENLSINKTLEMDELTRLDSMINELESRKLKILERVKHIDSKSTNLENDVTLIKDRINFIEEYSLEADREQSLRKQMEEERSSEASSFTQNEEAISSLYDVESKDTRLKDFYKMPHEKSHDKNRQMHIISETYSRNSTAFRMTIPHGEHGNSITALDFDTPWGTLCSSSYQDRIVKVWDLNHGIQVGELPGHLATVNCMQIDKKNYNMLITGSKDATLKLWDLNLSRELYLDHSPLKEKTEEIVTPCIHNFELHKDEITALSFDSEALVSGSRDKKIFHWDLTTGKCIQQLDLIFTPTHSDIKMPARSLNNGTCLLGTEAPMIGALQCYNSALATGTKDGLVRLWDLRVGKPVRLLEGHTDGITSLKFDSEKLVTGSMDNSVRIWDLRTSSILDVIAYDLPVSSLDFDGKLITVGANEGGVNVFNMERDEHWMTPEPPHSLDGDELSRRIAIVKYKDGFLINGHNDGDINVWTL","sequence_length":645,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"2df5d1e4a9826c8f1506731c1a9fe3d09bb6ceebed9f5aab0ef0cfa8a527c64d","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/A6ZZZ8.json","taxon_id":"307796","uniprot_accession":"A6ZZZ8","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/caf4-pf11615.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11615","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/caf4-pf11615.yaml"}],"pfam_ids":["PF00400","PF11615"],"protein_name":"CCR4-associated factor 4","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGSGDTRGESSLVAKPIEIILNKLPHAILAQQQFQKYITSPIYRYLSKLLLFREVAWPESTKDTQKGQVGIFSFQNNYADSATTFRILAHLDEQRYPLPNGAAEKNLPSLFEGFKATVSIIQQRLLLDNVDGATNSDKEKYVQLPDINTGFVNKTYSRIDLTHLLEDVETNVENLSINKTLEMDELTRLDSMINELESRKLKILERVKHIDSKSTNLENDVTLIKDRINFIEEYNLEADREQSLRKQMEEERSSEASSFTQNEEAISSLCDVESKDTRLKDFYKMPHEKSHDKNRQIISETYSRNTTAFRMTIPHGEHGNSITALDFDTPWGTLCSSSYQDRIVKVWDLNHGIQVGELPGHLATVNCMQIDKKNYNMLITGSKDATLKLWDLNLSREIYLDHSPLKEKTEEIVTPCIHNFELHKDEITALSFDSEALVSGSRDKKIFHWDLTTGKCIQQLDLIFTPTHSDIKMPARSLNNGACLLGTEAPMIGALQCYNSALATGTKDGIVRLWDLRVGKPVRLLEGHTDGITSLKFDSEKLVTGSMDNSVRIWDLRTSSILDVIAYDLPVSSLDFDGKLITVGANEGGVNVFNMERDEHWMTPEPPHSLDGDELSRRIAIVKYKDGFLINGHNDGDINVWTL","sequence_length":643,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"95dec02f1ecb7f9b8d2a8729b18a8159d8a104d35550b38368016d63db84f2a1","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/P36130.json","taxon_id":"559292","uniprot_accession":"P36130","uniprot_release":"2026_03"}],"pfam_id":"PF11615","short_name":"Caf4","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}