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This domain is responsible for the negative regulation of CSR [[cite:PUB00099259]].","domain_architectures":29,"interpro_id":"IPR021777","known_evidence_count":null,"matches":1469,"name":"SANT and BTB domain regulator of CSR, BTB domain","partial_evidence_count":null,"pfam_id":"PF11822","proteins":1467,"proteomes":934,"short_name":"BTB_SANBR","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11822","structures":0,"taxa":3290,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF11822.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1256,"domain_architectures":29,"matches":1469,"proteins":1467,"proteomes":934,"structures":0,"taxa":3290},"curation_status":"SEEDED","description":"Class switch recombination (CSR) is the process by which B cells switch production from IgM/IgD to other immunoglobulin isotypes in the immune response process. This entry represents the BTB domain found at the N-terminal half of the protein SANT and BTB domain regulator of class switch recombination (SANBR, previously known as KIAA1841). This domain is responsible for the negative regulation of CSR [[cite:PUB00099259]].","id":"Pfam:PF11822","interpro_id":"InterPro:IPR021777","name":"SANT and BTB domain regulator of CSR, BTB 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