{"cross_mech":[],"family":{"alphafold_models":3578,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"Nuclear receptors (NRs) are a family of ligand-inducible transcription factors, and, like other transcription factors, they contain a distinct DNA binding domain that allows for target gene recognition and several activation domains that possess the ability to activate transcription [[cite:PUB00063250]]. One of these activation domains is at the N-terminal, although there are two distinct motifs within this domain, between residues 20-36 and between 74 and the end of this domain, which are the binding regions. One of the co-activators is TIF1beta, which appears to bind at the first motif [[cite:PUB00063251]].","domain_architectures":16,"interpro_id":"IPR021780","known_evidence_count":null,"matches":3914,"name":"Nuclear/hormone receptor activator site AF-1","partial_evidence_count":null,"pfam_id":"PF11825","proteins":3896,"proteomes":744,"short_name":"Nuc_recep-AF1","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11825","structures":5,"taxa":2283,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF11825.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3578,"domain_architectures":16,"matches":3914,"proteins":3896,"proteomes":744,"structures":5,"taxa":2283},"curation_status":"SEEDED","description":"Nuclear receptors (NRs) are a family of ligand-inducible transcription factors, and, like other transcription factors, they contain a distinct DNA binding domain that allows for target gene recognition and several activation domains that possess the ability to activate transcription [[cite:PUB00063250]]. One of these activation domains is at the N-terminal, although there are two distinct motifs within this domain, between residues 20-36 and between 74 and the end of this domain, which are the binding regions. One of the co-activators is TIF1beta, which appears to bind at the first motif [[cite:PUB00063251]].","id":"Pfam:PF11825","interpro_id":"InterPro:IPR021780","name":"Nuclear/hormone receptor activator site AF-1","pfam_id":"PF11825","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Nuc_recep-AF1","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11825"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF11825.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"b7f86cebfd56464cb18faaaa555529c429253ce4fcb9c277b722e95496d320c9"}},"protein_examples":{"candidate_count":4,"discovery_scanned":true,"example_count":4,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/nuc-recep-af1-pf11825.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11825","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/nuc-recep-af1-pf11825.yaml"}],"pfam_ids":["PF00104","PF00105","PF11825"],"protein_name":"Retinoic acid receptor RXR-alpha","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT","sequence_length":462,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"8e243e32883cfc5ef70c61b40fccb9f5c9241e4ff31f0797437cd643f82d9740","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P19793.json","taxon_id":"9606","uniprot_accession":"P19793","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/nuc-recep-af1-pf11825.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11825","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/nuc-recep-af1-pf11825.yaml"}],"pfam_ids":["PF00104","PF00105","PF11825"],"protein_name":"Retinoic acid receptor RXR-alpha","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MDTKHFLPLDFSTQVNSSSLNSPTGRGSMAVPSLHPSLGPGIGSPLGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFGTGSPQLNSPMNPVSSTEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVEKILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQAT","sequence_length":467,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"d4f58525f3955d72cdcad5fc3eb3be55fbf2bc1eb591aa4f94ea4c076354fcd1","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P28700.json","taxon_id":"10090","uniprot_accession":"P28700","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/nuc-recep-af1-pf11825.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11825","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/nuc-recep-af1-pf11825.yaml"}],"pfam_ids":["PF00104","PF00105","PF11825"],"protein_name":"Retinoic acid receptor RXR-gamma","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MYGNYSHFMKFPTGFGGSPGHTGSTSMSPSVALPTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECASSSHEDMPVERILEAELAVEPKTESYGDMNVENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDSFLMEMLETPLQIT","sequence_length":463,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"a019a0900ce3406811a10f6fe496a70c0fa6d5d198d2da59f615cf44a724640f","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P28705.json","taxon_id":"10090","uniprot_accession":"P28705","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/nuc-recep-af1-pf11825.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11825","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/nuc-recep-af1-pf11825.yaml"}],"pfam_ids":["PF00104","PF00105","PF11825"],"protein_name":"Retinoic acid receptor RXR-gamma","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT","sequence_length":463,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"bfcf6d321aeb668b69f32761a2ffc17ddf8b66da1761a9d0ea14562855923b98","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P48443.json","taxon_id":"9606","uniprot_accession":"P48443","uniprot_release":"2026_03"}],"pfam_id":"PF11825","short_name":"Nuc_recep-AF1","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}