{"cross_mech":[],"family":{"alphafold_models":2822,"candidate_reasons":["description_says_unknown_function","pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain is found at the C-terminal of Type I restriction enzyme HindI endonuclease subunit (also known as R protein) from Haemophilus influenzae related sequences from bacteria and archaea [[cite:PUB00099965]]. This domain is typically between 255 to 340 amino acids in length and its function is unknown. This domain is found associated with [pfam:PF04851], [pfam:PF04313].","domain_architectures":31,"interpro_id":"IPR021810","known_evidence_count":null,"matches":4181,"name":"Type I restriction enzyme HindI endonuclease subunit-like, C-terminal","partial_evidence_count":null,"pfam_id":"PF11867","proteins":4176,"proteomes":3576,"short_name":"T1RH-like_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11867","structures":0,"taxa":6761,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF11867.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2822,"domain_architectures":31,"matches":4181,"proteins":4176,"proteomes":3576,"structures":0,"taxa":6761},"curation_status":"SEEDED","description":"This domain is found at the C-terminal of Type I restriction enzyme HindI endonuclease subunit (also known as R protein) from Haemophilus influenzae related sequences from bacteria and archaea [[cite:PUB00099965]]. This domain is typically between 255 to 340 amino acids in length and its function is unknown. This domain is found associated with [pfam:PF04851], [pfam:PF04313].","id":"Pfam:PF11867","interpro_id":"InterPro:IPR021810","name":"Type I restriction enzyme HindI endonuclease subunit-like, C-terminal","pfam_id":"PF11867","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"T1RH-like_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11867"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF11867.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"cc5917da67dd4e2ee735bf7abba560519b0ee8f7871b614952d1472984bfa302"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/t1rh-like-c-pf11867.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11867","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/t1rh-like-c-pf11867.yaml"}],"pfam_ids":["PF04313","PF11867","PF18766","PF22679"],"protein_name":"Putative type I restriction enzyme MjaIXP endonuclease subunit","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MPISANKYFLLVGVFIGDKMKKEAAKLNEDYVVENAAIQRLKNLGYSYKHGSELTPEYNERESYRDAILKNRFIKAIKNINPWLTEELALKVYKTVTNIDNPDFNMRGKIFYEMLINGVKLEFKENGEKKTRFVKLIDFENINKNEFLVANQFEVEYYYENGRFRRPDLVVFINGIPIAIFEFKSPKSNQTAKDAFNDHKTKMKDIPQLYQYAQILVVSDGLETKYGSPTSDWDRFFVWEGVESDDDVEVIEVDNYGNTMYKYKGNPYTSLDILLMGLFKKEHLIEFLEDFIIHDKKKIIATYYQFYTVKKAVDRTIKSVLYGETPEDRRIGIVWHAQGTGKSITMLFYAKKALKQKELNYPLLVFLTDRLELDEQLYNVFSSVFSEAERAESIAELQELIKKTPGGIIFATIQKFGRKSKDEHYPFLTDRNNIIIIADEAHRSHYGTLAQNLRKAIPNASFLAFTATPIDYKDRSTFLVFGDYISAYPIDKAKRHGVVVPIYYEARLVELHLTNEFIDLEFDEISERVANDPETKESIKEVFAKLEKIMLTEDYLSKVSKDIIEHFNKRLQDFDGKAMVVTISRKVAVELYKWITKQPNAPKIAVVMSGNKSKDPEDFHPHIRTKKELENLAKEFKDPESDLKMVIVVDMWLTGFDVPCLHTMYFLKPMKNHSLAQAIARVNRVFKDKPGGLIVDYIGIADDLSKSLSKYSSEARKDLMTDIKVVIEEMKRRYEKVTSYFKNINYKDWKKLSSEDLSLLTVKAYQRVAKDDNTKKEFVRNVIALKKLYLLARPHPETIGIKDDLEFFEMIKKMIVKYSTKKIREISQDLENDIQSLISKSISAKELVDVFEMLKKEKPELSVLSDEFLSEIAKIEYKDYVRDVLIKILNDDIRVRMAKNPIRFKKFSERLNEVIEKYRIKVITTAEMIEELVNLAKEIRKAAEEGKELGLTEEELAFYDLLLSYPNIPLTDKKRVEKIAKEIARMMSGYIKARDWKKKKNLQSKIRAKLKIILMKEGIKDYSLINKISDDLFEYAKNIYAI","sequence_length":1042,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"91d25477cb686274b20ab47a157b97bd4f81727da254057cfb184c732ba9978a","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q60295.json","taxon_id":"243232","uniprot_accession":"Q60295","uniprot_release":"2026_03"}],"pfam_id":"PF11867","short_name":"T1RH-like_C","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}