{"cross_mech":[],"family":{"alphafold_models":2989,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is the C-terminal domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins involved in the ribosomal quality control pathway. This context is conserved in archaea and eukaryotes, but NFACT proteins in bacteria lack the NFACT-C domain [[cite:PUB00091027]].","domain_architectures":50,"interpro_id":"IPR021846","known_evidence_count":null,"matches":3636,"name":"NFACT protein C-terminal domain","partial_evidence_count":null,"pfam_id":"PF11923","proteins":3629,"proteomes":2945,"short_name":"NFACT-C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11923","structures":9,"taxa":7889,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF11923.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2989,"domain_architectures":50,"matches":3636,"proteins":3629,"proteomes":2945,"structures":9,"taxa":7889},"curation_status":"SEEDED","description":"This is the C-terminal domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins involved in the ribosomal quality control pathway. This context is conserved in archaea and eukaryotes, but NFACT proteins in bacteria lack the NFACT-C domain [[cite:PUB00091027]].","id":"Pfam:PF11923","interpro_id":"InterPro:IPR021846","name":"NFACT protein C-terminal domain","pfam_id":"PF11923","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"NFACT-C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11923"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF11923.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"d2a4c24d3ff3ad52b2143b3524b7f10a13cbd4dbc7a15a044bbf97720522a862"}},"protein_examples":{"candidate_count":4,"discovery_scanned":true,"example_count":4,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/alpha-aminoacyl-trna-binding-go1904678.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1904678","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/alpha-aminoacyl-trna-binding-go1904678.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/cat-tailing-go0140708.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0140708","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/cat-tailing-go0140708.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/nfact-protein-c-terminal-ipr021846.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR021846","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/nfact-protein-c-terminal-ipr021846.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/nfact-rna-binding-domain-ipr008532.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR008532","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/nfact-rna-binding-domain-ipr008532.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nfact-c-pf11923.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11923","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nfact-c-pf11923.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nfact-r-1-pf05670.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF05670","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nfact-r-1-pf05670.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/nfact-n-pf05833.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF05833","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/nfact-n-pf05833.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/ibrinogen-binding-protein-from-staphylococcus-aureus-domain-2-30-310-10.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.30.310.10","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/ibrinogen-binding-protein-from-staphylococcus-aureus-domain-2-30-310-10.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:O60524","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF05670","PF05833","PF11923"],"protein_name":"Ribosome quality control complex subunit NEMF","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"d7e561416298f13d00a6b441c8d4330f7dbb27ad16bc25b5da8d09ab132990d8","sequence_version":4,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MKSRFSTIDLRAVLAELNASLLGMRVNNVYDVDNKTYLIRLQKPDFKATLLLESGIRIHTTEFEWPKNMMPSSFAMKCRKHLKSRRLVSAKQLGVDRIVDFQFGSDEAAYHLIIELYDRGNIVLTDYEYVILNILRFRTDEADDVKFAVRERYPLDHARAAEPLLTLERLTEIVASAPKGELLKRVLNPLLPYGPALIEHCLLENGFSGNVKVDEKLETKDIEKVLVSLQKAEDYMKTTSNFSGKGYIIQKREIKPSLEADKPVEDILTYEEFHPFLFSQHSQCPYIEFESFDKAVDEFYSKIEGQKIDLKALQQEKQALKKLDNVRKDHENRLEALQQAQEIDKLKGELIEMNLQIVDRAIQVVRSALANQIDWTEIGLIVKEAQAQGDPVASAIKELKLQTNHVTMLLRNPYLLSEEEDDDVDGDVNVEKNETEPPKGKKKKQKNKQLQKPQKNKPLLVDVDLSLSAYANAKKYYDHKRYAAKKTQKTVEAAEKAFKSAEKKTKQTLKEVQTVTSIQKARKVYWFEKFLWFISSENYLIIGGRDQQQNEIIVKRYLTPGDIYVHADLHGATSCVIKNPTGEPIPPRTLTEAGTMALCYSAAWDARVITSAWWVYHHQVSKTAPTGEYLTTGSFMIRGKKNFLPPSYLMMGFSFLFKVDESCVWRHQGERKVRVQDEDMETLASCTSELISEEMEQLDGGDTSSDEDKEEHETPVEVELMTQVDQEDITLQSGRDELNEELIQEESSEDEGEYEEVRKDQDSVGEMKDEGEETLNYPDTTIDLSHLQPQRSIQKLASKEESSNSSDSKSQSRRHLSAKERREMKKKKLPSDSGDLEALEGKDKEKESTVHIETHQNTSKNVAAVQPMKRGQKSKMKKMKEKYKDQDEEDRELIMKLLGSAGSNKEEKGKKGKKGKTKDEPVKKQPQKPRGGQRVSDNIKKETPFLEVITHELQDFAVDDPHDDKEEQDLDQQGNEENLFDSLTGQPHPEDVLLFAIPICAPYTTMTNYKYKVKLTPGVQKKGKAAKTALNSFMHSKEATAREKDLFRSVKDTDLSRNIPGKVKVSAPNLLNVKRK","sequence_length":1076,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"d7e561416298f13d00a6b441c8d4330f7dbb27ad16bc25b5da8d09ab132990d8","sequence_version":4,"source_url":"https://rest.uniprot.org/uniprotkb/O60524.json","taxon_id":"9606","uniprot_accession":"O60524","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/rqc-complex-go1990112.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1990112","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/rqc-complex-go1990112.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/alpha-aminoacyl-trna-binding-go1904678.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1904678","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/alpha-aminoacyl-trna-binding-go1904678.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/cat-tailing-go0140708.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0140708","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/cat-tailing-go0140708.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/peptide-biosynthetic-process-go0043043.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0043043","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/peptide-biosynthetic-process-go0043043.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/nfact-protein-c-terminal-ipr021846.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR021846","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/nfact-protein-c-terminal-ipr021846.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/nfact-rna-binding-domain-ipr008532.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR008532","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/nfact-rna-binding-domain-ipr008532.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nfact-c-pf11923.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11923","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nfact-c-pf11923.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nfact-r-1-pf05670.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF05670","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nfact-r-1-pf05670.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/nfact-n-pf05833.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF05833","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/nfact-n-pf05833.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/ibrinogen-binding-protein-from-staphylococcus-aureus-domain-2-30-310-10.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.30.310.10","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/ibrinogen-binding-protein-from-staphylococcus-aureus-domain-2-30-310-10.yaml"}],"pfam_ids":["PF05670","PF05833","PF11923"],"protein_name":"Ribosome quality control complex subunit 2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKQRISALDLLLLARELKQDLEGYRLSNIYNIADSSKQFLLKFNKPDSKLNVVVDCGLRIYLTEFSRPIPPTPSGFVVKLRKHLKAKRLTALKQVDQDRILVLQFADGHFYLVLEFFSAGNVILLDENRRIMALQRVVLEHENKVGQIYEMFDESLFTTNNESADESIEKNRKAEYTSELVNEWIKAVQAKYESDITVIKQLNIQGKEGAKKKKVKVPSIHKLLLSKVPHLSSDLLSKNLKVFNIDPSESCLNLLEETDSLAELLNSTQLEYNQLLTTTDRKGYILAKRNENYISEKDTADLEFIYDTFHPFKPYINGGDTDSSCIIEVEGPYNRTLDKFFSTIESSKYALRIQNQESQAQKKIDDARAENDRKIQALLDVQELNERKGHLIIENAPLIEEVKLAVQGLIDQQMDWNTIEKLIKSEQKKGNRIAQLLNLPLNLKQNKISVKLDLSSKELNTSSDEDNESEGNTTDSSSDSDSEDMESSKERSTKSMKRKSNEKINVTIDLGLSAYANATEYFNIKKTSAQKQKKVEKNVGKAMKNIEVKIDQQLKKKLKDSHSVLKKIRTPYFFEKYSWFISSEGFLVMMGKSPAETDQIYSKYIEDDDIYMSNSFNSHVWIKNPEKTEVPPNTLMQAGILCMSSSEAWSKKISSSPWWCFAKNVSKFDGSDNSILPEGAFRLKNENDQNHLPPAQLVMGFGFLWKVKTSGNEDNGDDDEEEEEEEEEEEEEEEEEEEEEEEEKEEEEKEEEQQQDEDDSNEVNGLEKGGDSNDSTKNNSFEHDNLEKDIEKHCTISSDTDSDSGNAKAKNDNSSTQRILDEPGVPISLIENINSNVRGKRGKLKKIQKKYADQDETERLLRLEALGTLKGIEKQQQRKKEEIMKREVREDRKNKREKQRRLQALKFTKKEKARVNYDKHKSELKPSLDKGDVVDDIIPVFAPWPALLKYKYKVKIQPGSAKKTKTLTEILHYFKSRPLDGSSTDNEMDWPQEHEMIKGLKEQDLVLLLCVDKLKVTIAGQKSTKNGGNSSKKGKKKR","sequence_length":1038,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"72e864a3e922b27710f9267d4aa91c18724c9138aaf5d5d7f22f7a75470ab8d6","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q12532.json","taxon_id":"559292","uniprot_accession":"Q12532","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/alpha-aminoacyl-trna-binding-go1904678.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1904678","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/alpha-aminoacyl-trna-binding-go1904678.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/cat-tailing-go0140708.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0140708","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/cat-tailing-go0140708.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/nfact-protein-c-terminal-ipr021846.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR021846","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/nfact-protein-c-terminal-ipr021846.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/nfact-rna-binding-domain-ipr008532.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR008532","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/nfact-rna-binding-domain-ipr008532.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nfact-c-pf11923.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11923","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nfact-c-pf11923.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nfact-r-1-pf05670.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF05670","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nfact-r-1-pf05670.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/nfact-n-pf05833.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF05833","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/nfact-n-pf05833.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/ibrinogen-binding-protein-from-staphylococcus-aureus-domain-2-30-310-10.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.30.310.10","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/ibrinogen-binding-protein-from-staphylococcus-aureus-domain-2-30-310-10.yaml"}],"pfam_ids":["PF05670","PF05833","PF11923"],"protein_name":"Ribosome quality control complex subunit NEMF","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKSRFSTVDLRAVLAELNASLLGMRVNNVYDVDNKTYLIRLQKPDFKATLLLESGIRIHTTEFEWPKNMMPSSFAMKCRKHLKSRRLVSAKQLGVDRIVDFQFGSDEAAYHLIIELYDRGNIVLTDYEYLILNILRFRTDEADDVKFAVRERYPIDHARAAEPLLTLERLTEVIAAAPKGEVLKRVLNPLLPYGPALIEHCLIESGFSGNAKVDEKLESKDIEKILVCVQRAEDYLRKTSNFNGKGYIIQKREAKPSLDADKPAEDILTYEEFHPFLFSQHLQCPYIEFESFDKAVDEFYSKIEGQKIDLKALQQEKQALKKLDNVRKDHENRLEALQQAQEIDKLKGELIEMNLQIVDRAIQVVRSALANQIDWTEIGVIVKEAQAQGDPVACAIKELKLQTNHVTMLLRNPYLLSEEEDGDGDASIENSDAEAPKGKKKKQKNKQLQKPQKNKPLLVDVDLSLSAYANAKKYYDHKRYAAKKTQRTVEAAEKAFKSAEKKTKQTLKEVQTVTSIQKARKVYWFEKFLWFISSENYLIIGGRDQQQNEIIVKRYLTPGDIYVHADLHGATSCVIKNPTGEPIPPRTLTEAGTMALCYSAAWDARVITSAWWVYHHQVSKTAPTGEYLTTGSFMIRGKKNFLPPSYLMMGFSFLFKVDESCVWRHRGERKVRVQDEDMETLTSCTSELMAEEMEQLEGGDSSEEETEELHGMPGDVELMTQVDQEDIAVHSGRDELSSEDGEAKAVTKDQEPIGEMKEEEEDTFEYPDTTIDLSHLQSQRPLQKLAPREESLNSNDSKSQGRRHLSAKERREMKKKKLPCESGDLEVIEEKDKERESAVHTEAYQNTSKNVAAGQPMKRGQKSKMKKMKEKYKDQDDEDRELIMKLLASAGSNKEEKGKKGKKGKPKDEPVKKPPQKPRGGQRVLDVVKEPPSLQVLAHDLQDLAVDDPHDDKEEHDLDQQGNEENLFDSLTGQPHPEDVLMFAIPICAPYTIMTNYKYKVKLTPGVQKKGKAAKTALNSFMHSKEATAREKDLFRSVKDTDLSRNIPGKVKVSAPNLLHVKRK","sequence_length":1064,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"7bdc54a29a7c2eb9f768fc61c98a29ef6af3a75384182ec306999e8ace04bbfe","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q8CCP0.json","taxon_id":"10090","uniprot_accession":"Q8CCP0","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/cat-tailing-go0140708.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0140708","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/cat-tailing-go0140708.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/positive-regulation-of-intrinsic-apoptotic-signaling-pathway-in-response-to-dna--go1902167.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1902167","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/positive-regulation-of-intrinsic-apoptotic-signaling-pathway-in-response-to-dna--go1902167.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/ribosome-rescue-protein-rqch-nf041120.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF041120","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/ribosome-rescue-protein-rqch-nf041120.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/nfact-protein-c-terminal-ipr021846.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR021846","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/nfact-protein-c-terminal-ipr021846.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/nfact-rna-binding-domain-ipr008532.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR008532","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/nfact-rna-binding-domain-ipr008532.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nfact-c-pf11923.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11923","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nfact-c-pf11923.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/nfact-r-1-pf05670.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF05670","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/nfact-r-1-pf05670.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/nfact-n-pf05833.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF05833","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/nfact-n-pf05833.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/ibrinogen-binding-protein-from-staphylococcus-aureus-domain-2-30-310-10.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:2.30.310.10","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/ibrinogen-binding-protein-from-staphylococcus-aureus-domain-2-30-310-10.yaml"}],"pfam_ids":["PF05670","PF05833","PF11923"],"protein_name":"Ribosome quality control complex subunit NEMF homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKTRFNTFDIICGVAELQKLVGWRVNQIYDVDNKTYLFRMQGTGAVEKVTLLIESGTRFHTTRFEWPKNMAPSGFSMKLRKHLKNKRLEKVQQMGSDRIVDFQFGTGDAAYHVILELYDRGNVILTDYELTTLYILRPHTEGENLRFAMREKYPVERAKQPTKELELEALVKLLENARNGDYLRQILTPNLDCGPAVIEHVLLSHGLDNHVIKKETTEETPEAEDKPEKGGKKQRKKQQNTKLEQKPFDMVNDLPILQQAVKDAQELIAEGNSGKSKGYIIQVKEEKPTENGTVEFFFRNIEFHPYLFIQFKNFEKATFESFMEAVDEFYSTQESQKIDMKTLQQEREALKKLSNVKNDHAKRLEELTKVQDVDRKKAELITSNQSLVDNAIRAVQSAIASQLSWPDIHELVKEAQANGDAVASSIKQLKLETNHISLMLSDPYDNDEDDDLKDPEVTVVDVDLALSAWANARRYYDMKRSAAQKEKKTVDASQKALKSAERKTQQTLKEVRTISNIVKARKVFWFEKFYWFISSENYLVIGGRDAQQNELIVKRYMRPKDIYVHAEIQGASSVIIQNPTGEEIPPKTLLEAGSMAISYSVAWDAKVVTNSYWVTSDQVSKTAPTGEYLATGSFMIRGKKNFLPSCHLTMGLSLLFKLEDSFIERHLGERKVRSLEDDQIDPNVKENEVEHDLLSDNEDADSNINLSEPSSNTEITAFPNTEVKIEHDTGRIIVRSDSVNPEIEETKESEVVLDKILKKTDDEETTIILAGPSRKKQVSAKKTKEDKARAKQEAAKQEVPPVSSEPKNPSQVKRGQKGKLKKMKQKYKDQDDEEREIRMMILKSSGKEKPQASADKVVEKSESTKEYVKPEKSAAPKNPVELDDADEVPVGGDVDVLNSLTGQPHEGDELLFAIPVVAPYQALQNYKFKVKLTPGTGKRGKAAKLALNIFAKEKSCSAREKDLLKSIKEESLARNIPGKVKLSAPQLQKYHK","sequence_length":992,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"85cc7c2f9efc32de283d8663d06b2150b37e342c26427b3b48a04f4bd7b3cb37","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q9VBX1.json","taxon_id":"7227","uniprot_accession":"Q9VBX1","uniprot_release":"2026_03"}],"pfam_id":"PF11923","short_name":"NFACT-C","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}