{"cross_mech":[],"family":{"alphafold_models":4748,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This protein family is found in fungi and bacteria, including the alpha subunit of an haem-dependent oxidative N-demethylase (HODM) from Pseudomonas mendocina. This protein, catalytically active, is responsible for haem, oxygen and NADPH-dependent dimethylamine (DMA) binding. It shows structural similarity to the to the Aer2 PAS domain, but lacks the core PAS-domain alpha-helix that forms the Aer2 haem pocket, and displays extended beta-strands and a longer loop [[cite:PUB00100877]]. The structure of [swissprot:A4XXY9], PDBe:5lte, shows that it is an haem-binding PAS domain, similar in structure to PAS gas sensors [[cite:PUB00100877]].","domain_architectures":88,"interpro_id":"IPR021848","known_evidence_count":null,"matches":6341,"name":"Haem-dependent oxidative N-demethylase, alpha subunit-like","partial_evidence_count":null,"pfam_id":"PF11927","proteins":6200,"proteomes":3026,"short_name":"HODM_asu-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11927","structures":3,"taxa":5492,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF11927.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":4748,"domain_architectures":88,"matches":6341,"proteins":6200,"proteomes":3026,"structures":3,"taxa":5492},"curation_status":"SEEDED","description":"This protein family is found in fungi and bacteria, including the alpha subunit of an haem-dependent oxidative N-demethylase (HODM) from Pseudomonas mendocina. This protein, catalytically active, is responsible for haem, oxygen and NADPH-dependent dimethylamine (DMA) binding. It shows structural similarity to the to the Aer2 PAS domain, but lacks the core PAS-domain alpha-helix that forms the Aer2 haem pocket, and displays extended beta-strands and a longer loop [[cite:PUB00100877]]. The structure of [swissprot:A4XXY9], PDBe:5lte, shows that it is an haem-binding PAS domain, similar in structure to PAS gas sensors [[cite:PUB00100877]].","id":"Pfam:PF11927","interpro_id":"InterPro:IPR021848","name":"Haem-dependent oxidative N-demethylase, alpha subunit-like","pfam_id":"PF11927","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"HODM_asu-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11927"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF11927.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"5106fd20314b35d7824d46d24ae37132de424d2fa0c1dcfbd4a401c6aa0be151"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Ectopseudomonas mendocina (strain ymp)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/hodm-asu-like-pf11927.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11927","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/hodm-asu-like-pf11927.yaml"}],"pfam_ids":["PF11927"],"protein_name":"Heme-dependent oxidative N-demethylase alpha subunit","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTLTFKPLESYREDFSFRNSPAAIARFPFPFPEDQYMYSVNLEPAVSRDPGSVFEHQFDVDEHYVSEMAERARVLELDPGRCLVMPHMAQAAWDTLAMLMEHLARDYPQHFRLTRQGDAWHWQNLALGIDQRFTFGDPASLPCEPLEYITRQMQGDFAVLDQRDGDLFMDAGMVTCPADWSLRFDAGMSFKQWHSPVPMAHQMGVFDRALKYLLNIQVGAPVRRLNWTLTINPRLDTSPETYHEWGNDRGKVTPDNVGRLVHLRVELQLMARLPRSNALLFGIRTYLISLDELVSNPAWAQRLHRVMRDLPDPIADYKGITRYRQTLVDWLRRFDPEA","sequence_length":338,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"75ea9108a4ed3d75fa901ba65e99729712f4656bf9b3d0e96a0e505fcbdb5087","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A4XXY9.json","taxon_id":"399739","uniprot_accession":"A4XXY9","uniprot_release":"2026_03"}],"pfam_id":"PF11927","short_name":"HODM_asu-like","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}