{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma family protein","reviewed":true,"short_name":"DUF3452","source_category":"function/localization/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/localization/go/drm-complex-go0070176.yaml","source_record_id":"GO:0070176","source_record_label":"DRM complex","source_section":"canonical_examples","taxon_id":"NCBITaxon:7227","taxon_label":"Drosophila melanogaster","uniprot_accession":"Q24472","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"function/localization/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/localization/go/drm-complex-go0070176.yaml","source_record_id":"GO:0070176","source_record_label":"DRM complex","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma family protein","reviewed":true,"short_name":"DUF3452","source_category":"function/localization/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/localization/go/myb-complex-go0031523.yaml","source_record_id":"GO:0031523","source_record_label":"Myb complex","source_section":"canonical_examples","taxon_id":"NCBITaxon:7227","taxon_label":"Drosophila melanogaster","uniprot_accession":"Q24472","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma family protein","reviewed":true,"short_name":"DUF3452","source_category":"function/localization/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/localization/go/rb-e2f-complex-go0035189.yaml","source_record_id":"GO:0035189","source_record_label":"Rb-E2F complex","source_section":"canonical_examples","taxon_id":"NCBITaxon:7227","taxon_label":"Drosophila melanogaster","uniprot_accession":"Q24472","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/double-fertilization-forming-a-zygote-and-endosperm-go0009567.yaml","source_record_id":"GO:0009567","source_record_label":"double fertilization forming a zygote and endosperm","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma family protein","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/eggshell-chorion-gene-amplification-go0007307.yaml","source_record_id":"GO:0007307","source_record_label":"eggshell chorion gene amplification","source_section":"canonical_examples","taxon_id":"NCBITaxon:7227","taxon_label":"Drosophila melanogaster","uniprot_accession":"Q24472","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/embryo-sac-development-go0009553.yaml","source_record_id":"GO:0009553","source_record_label":"embryo sac development","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma family protein","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/endomitotic-cell-cycle-go0007113.yaml","source_record_id":"GO:0007113","source_record_label":"endomitotic cell cycle","source_section":"canonical_examples","taxon_id":"NCBITaxon:7227","taxon_label":"Drosophila melanogaster","uniprot_accession":"Q24472","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/endosperm-development-go0009960.yaml","source_record_id":"GO:0009960","source_record_label":"endosperm development","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/gametophyte-development-go0048229.yaml","source_record_id":"GO:0048229","source_record_label":"gametophyte development","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/generative-cell-differentiation-go0022619.yaml","source_record_id":"GO:0022619","source_record_label":"generative cell differentiation","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/guard-cell-fate-commitment-go0010377.yaml","source_record_id":"GO:0010377","source_record_label":"guard cell fate commitment","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/homologous-chromosome-pairing-at-meiosis-go0007129.yaml","source_record_id":"GO:0007129","source_record_label":"homologous chromosome pairing at meiosis","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-like protein homolog lin-35","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/negative-regulation-of-cell-cycle-g1-s-phase-transition-go1902807.yaml","source_record_id":"GO:1902807","source_record_label":"negative regulation of cell cycle G1/S phase transition","source_section":"canonical_examples","taxon_id":"NCBITaxon:6239","taxon_label":"Caenorhabditis elegans","uniprot_accession":"G5EDT1","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-like protein homolog lin-35","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/negative-regulation-of-dna-endoreduplication-go0032876.yaml","source_record_id":"GO:0032876","source_record_label":"negative regulation of DNA endoreduplication","source_section":"canonical_examples","taxon_id":"NCBITaxon:6239","taxon_label":"Caenorhabditis elegans","uniprot_accession":"G5EDT1","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma family protein","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/negative-regulation-of-dna-replication-go0008156.yaml","source_record_id":"GO:0008156","source_record_label":"negative regulation of DNA replication","source_section":"canonical_examples","taxon_id":"NCBITaxon:7227","taxon_label":"Drosophila melanogaster","uniprot_accession":"Q24472","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-like protein homolog lin-35","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/negative-regulation-of-transcription-by-rna-polymerase-i-go0016479.yaml","source_record_id":"GO:0016479","source_record_label":"negative regulation of transcription by RNA polymerase I","source_section":"canonical_examples","taxon_id":"NCBITaxon:6239","taxon_label":"Caenorhabditis elegans","uniprot_accession":"G5EDT1","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/negative-regulation-of-transcription-by-rna-polymerase-iii-go0016480.yaml","source_record_id":"GO:0016480","source_record_label":"negative regulation of transcription by RNA polymerase III","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-like protein homolog lin-35","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/negative-regulation-of-vulval-development-go0040027.yaml","source_record_id":"GO:0040027","source_record_label":"negative regulation of vulval development","source_section":"canonical_examples","taxon_id":"NCBITaxon:6239","taxon_label":"Caenorhabditis elegans","uniprot_accession":"G5EDT1","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/palisade-mesophyll-development-go1903866.yaml","source_record_id":"GO:1903866","source_record_label":"palisade mesophyll development","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-like protein homolog lin-35","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/positive-regulation-of-brood-size-go0090727.yaml","source_record_id":"GO:0090727","source_record_label":"positive regulation of brood size","source_section":"canonical_examples","taxon_id":"NCBITaxon:6239","taxon_label":"Caenorhabditis elegans","uniprot_accession":"G5EDT1","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma family protein","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/regulation-of-chromosome-segregation-go0051983.yaml","source_record_id":"GO:0051983","source_record_label":"regulation of chromosome segregation","source_section":"canonical_examples","taxon_id":"NCBITaxon:7227","taxon_label":"Drosophila melanogaster","uniprot_accession":"Q24472","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/regulation-of-dna-endoreduplication-go0032875.yaml","source_record_id":"GO:0032875","source_record_label":"regulation of DNA endoreduplication","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma family protein","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/regulation-of-execution-phase-of-apoptosis-go1900117.yaml","source_record_id":"GO:1900117","source_record_label":"regulation of execution phase of apoptosis","source_section":"canonical_examples","taxon_id":"NCBITaxon:7227","taxon_label":"Drosophila melanogaster","uniprot_accession":"Q24472","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/regulation-of-nuclear-division-go0051783.yaml","source_record_id":"GO:0051783","source_record_label":"regulation of nuclear division","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/regulation-of-stem-cell-population-maintenance-go2000036.yaml","source_record_id":"GO:2000036","source_record_label":"regulation of stem cell population maintenance","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/trichome-morphogenesis-go0010090.yaml","source_record_id":"GO:0010090","source_record_label":"trichome morphogenesis","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"sequence/domain/cdd","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/cdd/cyclin-box-found-in-arabidopsis-thaliana-retinoblastoma-related-protei-cd20601.yaml","source_record_id":"CDD:cd20601","source_record_label":"CYCLIN_AtRBR_like","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-like protein homolog lin-35","reviewed":true,"short_name":"DUF3452","source_category":"sequence/domain/cdd","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/cdd/cyclin-box-found-in-retinoblastoma-associated-protein-rb-family-the-rb-cd20548.yaml","source_record_id":"CDD:cd20548","source_record_label":"CYCLIN_RB-like","source_section":"canonical_examples","taxon_id":"NCBITaxon:6239","taxon_label":"Caenorhabditis elegans","uniprot_accession":"G5EDT1","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma family protein","reviewed":true,"short_name":"DUF3452","source_category":"sequence/domain/cdd","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/cdd/cyclin-box-found-in-retinoblastoma-associated-protein-rb-family-the-rb-cd20548.yaml","source_record_id":"CDD:cd20548","source_record_label":"CYCLIN_RB-like","source_section":"canonical_examples","taxon_id":"NCBITaxon:7227","taxon_label":"Drosophila melanogaster","uniprot_accession":"Q24472","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-like protein homolog lin-35","reviewed":true,"short_name":"DUF3452","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-a-box-ipr002720.yaml","source_record_id":"InterPro:IPR002720","source_record_label":"Retinoblastoma-associated protein, A-box","source_section":"canonical_examples","taxon_id":"NCBITaxon:6239","taxon_label":"Caenorhabditis elegans","uniprot_accession":"G5EDT1","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma family protein","reviewed":true,"short_name":"DUF3452","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-a-box-ipr002720.yaml","source_record_id":"InterPro:IPR002720","source_record_label":"Retinoblastoma-associated protein, A-box","source_section":"canonical_examples","taxon_id":"NCBITaxon:7227","taxon_label":"Drosophila melanogaster","uniprot_accession":"Q24472","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-a-box-ipr002720.yaml","source_record_id":"InterPro:IPR002720","source_record_label":"Retinoblastoma-associated protein, A-box","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-like protein homolog lin-35","reviewed":true,"short_name":"DUF3452","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-b-box-ipr002719.yaml","source_record_id":"InterPro:IPR002719","source_record_label":"Retinoblastoma-associated protein, B-box","source_section":"canonical_examples","taxon_id":"NCBITaxon:6239","taxon_label":"Caenorhabditis elegans","uniprot_accession":"G5EDT1","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma family protein","reviewed":true,"short_name":"DUF3452","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-b-box-ipr002719.yaml","source_record_id":"InterPro:IPR002719","source_record_label":"Retinoblastoma-associated protein, B-box","source_section":"canonical_examples","taxon_id":"NCBITaxon:7227","taxon_label":"Drosophila melanogaster","uniprot_accession":"Q24472","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-b-box-ipr002719.yaml","source_record_id":"InterPro:IPR002719","source_record_label":"Retinoblastoma-associated protein, B-box","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-like protein homolog lin-35","reviewed":true,"short_name":"DUF3452","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-n-terminal-ipr024599.yaml","source_record_id":"InterPro:IPR024599","source_record_label":"Retinoblastoma-associated protein, N-terminal","source_section":"canonical_examples","taxon_id":"NCBITaxon:6239","taxon_label":"Caenorhabditis elegans","uniprot_accession":"G5EDT1","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma family protein","reviewed":true,"short_name":"DUF3452","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-n-terminal-ipr024599.yaml","source_record_id":"InterPro:IPR024599","source_record_label":"Retinoblastoma-associated protein, N-terminal","source_section":"canonical_examples","taxon_id":"NCBITaxon:7227","taxon_label":"Drosophila melanogaster","uniprot_accession":"Q24472","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-n-terminal-ipr024599.yaml","source_record_id":"InterPro:IPR024599","source_record_label":"Retinoblastoma-associated protein, N-terminal","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF11934","protein_label":"","reviewed":null,"short_name":"DUF3452","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-n-terminal-ipr024599.yaml","source_record_id":"InterPro:IPR024599","source_record_label":"Retinoblastoma-associated protein, N-terminal","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-like protein homolog lin-35","reviewed":true,"short_name":"DUF3452","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/rb-a-pf01858.yaml","source_record_id":"Pfam:PF01858","source_record_label":"Retinoblastoma-associated protein A domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:6239","taxon_label":"Caenorhabditis elegans","uniprot_accession":"G5EDT1","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma family protein","reviewed":true,"short_name":"DUF3452","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/rb-a-pf01858.yaml","source_record_id":"Pfam:PF01858","source_record_label":"Retinoblastoma-associated protein A domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:7227","taxon_label":"Drosophila melanogaster","uniprot_accession":"Q24472","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/rb-a-pf01858.yaml","source_record_id":"Pfam:PF01858","source_record_label":"Retinoblastoma-associated protein A domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-like protein homolog lin-35","reviewed":true,"short_name":"DUF3452","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/rb-b-pf01857.yaml","source_record_id":"Pfam:PF01857","source_record_label":"Retinoblastoma-associated protein B domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:6239","taxon_label":"Caenorhabditis elegans","uniprot_accession":"G5EDT1","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma family protein","reviewed":true,"short_name":"DUF3452","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/rb-b-pf01857.yaml","source_record_id":"Pfam:PF01857","source_record_label":"Retinoblastoma-associated protein B domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:7227","taxon_label":"Drosophila melanogaster","uniprot_accession":"Q24472","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-related protein 1","reviewed":true,"short_name":"DUF3452","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/rb-b-pf01857.yaml","source_record_id":"Pfam:PF01857","source_record_label":"Retinoblastoma-associated protein B domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9LKZ3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-associated protein","reviewed":true,"short_name":"DUF3452","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3452-pf11934.yaml","source_record_id":"Pfam:PF11934","source_record_label":"Domain of unknown function (DUF3452)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"P06400","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-like protein 1","reviewed":true,"short_name":"DUF3452","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3452-pf11934.yaml","source_record_id":"Pfam:PF11934","source_record_label":"Domain of unknown function (DUF3452)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"P28749","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-like protein 2","reviewed":true,"short_name":"DUF3452","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3452-pf11934.yaml","source_record_id":"Pfam:PF11934","source_record_label":"Domain of unknown function (DUF3452)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q08999","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF11934","protein_label":"","reviewed":null,"short_name":"DUF3452","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3452-pf11934.yaml","source_record_id":"Pfam:PF11934","source_record_label":"Domain of unknown function (DUF3452)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma-like protein homolog lin-35","reviewed":true,"short_name":"DUF3452","source_category":"structure/homologous_superfamily/cath","source_mech":"ProteinTraitsMech","source_path":"data/traits/structure/homologous_superfamily/cath/1-10-472-140-1-10-472-140.yaml","source_record_id":"CATH:1.10.472.140","source_record_label":"CATH homologous superfamily 1.10.472.140","source_section":"canonical_examples","taxon_id":"NCBITaxon:6239","taxon_label":"Caenorhabditis elegans","uniprot_accession":"G5EDT1","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11934","protein_label":"Retinoblastoma family protein","reviewed":true,"short_name":"DUF3452","source_category":"structure/homologous_superfamily/cath","source_mech":"ProteinTraitsMech","source_path":"data/traits/structure/homologous_superfamily/cath/1-10-472-140-1-10-472-140.yaml","source_record_id":"CATH:1.10.472.140","source_record_label":"CATH homologous superfamily 1.10.472.140","source_section":"canonical_examples","taxon_id":"NCBITaxon:7227","taxon_label":"Drosophila melanogaster","uniprot_accession":"Q24472","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":4435,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":6,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":35},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 124 to 150 amino acids in length. This domain is found associated with [pfam:PF01858], [pfam:PF01857]. This domain has a single completely conserved residue W that may be functionally important.","domain_architectures":53,"interpro_id":"IPR024599","known_evidence_count":null,"matches":5123,"name":"Domain of unknown function (DUF3452)","partial_evidence_count":null,"pfam_id":"PF11934","proteins":5112,"proteomes":1687,"short_name":"DUF3452","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11934","structures":2,"taxa":5318,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF11934.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":4435,"domain_architectures":53,"matches":5123,"proteins":5112,"proteomes":1687,"structures":2,"taxa":5318},"curation_status":"SEEDED","description":"This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 124 to 150 amino acids in length. This domain is found associated with [pfam:PF01858], [pfam:PF01857]. This domain has a single completely conserved residue W that may be functionally important.","id":"Pfam:PF11934","interpro_id":"InterPro:IPR024599","name":"Domain of unknown function (DUF3452)","pfam_id":"PF11934","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF3452","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11934"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF11934.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"aa7df55a7a42574d33ed6f6082f4a6f5a799aa7232e99ff741a1206da7d1586d"}},"protein_examples":{"candidate_count":6,"discovery_scanned":true,"example_count":6,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Caenorhabditis elegans","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/negative-regulation-of-cell-cycle-g1-s-phase-transition-go1902807.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1902807","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/negative-regulation-of-cell-cycle-g1-s-phase-transition-go1902807.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/negative-regulation-of-dna-endoreduplication-go0032876.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0032876","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/negative-regulation-of-dna-endoreduplication-go0032876.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/negative-regulation-of-transcription-by-rna-polymerase-i-go0016479.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0016479","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/negative-regulation-of-transcription-by-rna-polymerase-i-go0016479.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/negative-regulation-of-vulval-development-go0040027.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0040027","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/negative-regulation-of-vulval-development-go0040027.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/positive-regulation-of-brood-size-go0090727.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0090727","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/positive-regulation-of-brood-size-go0090727.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/cyclin-box-found-in-retinoblastoma-associated-protein-rb-family-the-rb-cd20548.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd20548","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/cyclin-box-found-in-retinoblastoma-associated-protein-rb-family-the-rb-cd20548.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-a-box-ipr002720.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR002720","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-a-box-ipr002720.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-b-box-ipr002719.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR002719","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-b-box-ipr002719.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-n-terminal-ipr024599.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR024599","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-n-terminal-ipr024599.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/rb-a-pf01858.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF01858","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/rb-a-pf01858.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/rb-b-pf01857.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF01857","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/rb-b-pf01857.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/1-10-472-140-1-10-472-140.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.10.472.140","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/1-10-472-140-1-10-472-140.yaml"}],"pfam_ids":["PF01857","PF01858","PF11934"],"protein_name":"Retinoblastoma-like protein homolog lin-35","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MPKRAADEPGTSTTDPFHEQSPFDAVLAGTETTDTICEEPPAKRIDLDIKQEFNGGVQSGGLIKNESELTQMTIKQETEGNINEARREEEDEEQDEDSRTSMPPALGEDDDYEEDDADSFIDKTNTPPPSQSFLEGCRAANLPNDIVTGAWETYNHAVQRVSLEGSESAWQLSAIYYYLLSKGIKRRGKTIRILIQPFPVSILTIANSFDISVAEMLDKTARFVEIIHSRKIRRYQEYIRRIQEGLAVSCVIFKKFCRIFCKIFEEIKVGSENCPSSHELFTVLWTSFLVMKSRMTVDDLISNYQLLFSILDQVYTEMCSMKEGIVHHLNQKFVEDLLENDCTIIRALCTQFGGSVLDARHFSDHTFKKMEKTGIPSTWNFQEFRDLIMNVPKTAYENYLLQRGSIDERIFIPSVEDFSKIFQSPDTYSVADILKVSYSGRRFRDAEFLTKISNNHCLEKLALGGKVASEKLVTQSKEQPRVPCVEYNLELGNYPDDLESNNQSLYNRLTKIIGSWKLENSKLEEVCGTMSDSPMATILLKSDEMTNKFERTLSAELGETINENIPKYHYNVRKELELVFLIFMEKIIVAELKKKVREEDLLNVIRREEFLDSVFCFCVELILVSNGYDRPFPWSAELCGVHPFMFHKVIDLMITHEKQLSRQMVQHFSRIEETVIEYFSWKSDSPLWPMVVRCPFAHFQEFGEDWADKLNSYSPIKFTPIKKPDDLRDELGRPIVPQNQTSRTLRIFLKRTYFTAARRLQDLTDRVSMGARAKSQCWSLFDYLLRNDTLIFMDRHLDQILLCCVFVIMKINESSMLFTEIMAQYRRQSANSLLVYRSVTVFQEQLNPENPQAVNTKETILERLEGPQKEKTTVDIIKYYNIEFRDRIKYIIGQIDSASDEDLMEMPVATESGLMPVRVYLTHKLSIQTLPKTKHGESKQERAIANLEKSGITIAMERSGD","sequence_length":961,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"8145b90810b1e0764414e4fbffba85ffefe454e4ac6e58ca3120b5b448aeb8a9","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/G5EDT1.json","taxon_id":"6239","uniprot_accession":"G5EDT1","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf3452-pf11934.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11934","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf3452-pf11934.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P06400","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF01857","PF01858","PF08934","PF11934"],"protein_name":"Retinoblastoma-associated protein","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"8be63dca6cc82885cff6629df4ff5401afaa56f9a463140e77a51e46ba011ad0","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTSTRTRMQKQKMNDSMDTSNKEEK","sequence_length":928,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"8be63dca6cc82885cff6629df4ff5401afaa56f9a463140e77a51e46ba011ad0","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P06400.json","taxon_id":"9606","uniprot_accession":"P06400","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf3452-pf11934.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11934","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf3452-pf11934.yaml"}],"pfam_ids":["PF01857","PF01858","PF08934","PF11934"],"protein_name":"Retinoblastoma-like protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MFEDKPHAEGAAVVAAAGEALQALCQELNLDEGSAAEALDDFTAIRGNYSLEGEVTHWLACSLYVACRKSIIPTVGKGIMEGNCVSLTRILRSAKLSLIQFFSKMKKWMDMSNLPQEFRERIERLERNFEVSTVIFKKYEPIFLDIFQNPYEEPPKLPRSRKQRRIPCSVKDLFNFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPNRQDLLNPSFKGLPSDFHTADFTASEEPPCIIAVLCELHDGLLVEAKGIKEHYFKPYISKLFDRKILKGECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRKFTRDTPLGKLTAQANVEYNLQQHFEKKRSFAPSTPLTGRRYLREKEAVITPVASATQSVSRLQSIVAGLKNAPSDQLINIFESCVRNPVENIMKILKGIGETFCQHYTQSTDEQPGSHIDFAVNRLKLAEILYYKILETVMVQETRRLHGMDMSVLLEQDIFHRSLMACCLEIVLFAYSSPRTFPWIIEVLNLQPFYFYKVIEVVIRSEEGLSRDMVKHLNSIEEQILESLAWSHDSALWEALQVSANKVPTCEEVIFPNNFETGNGGNVQGHLPLMPMSPLMHPRVKEVRTDSGSLRRDMQPLSPISVHERYSSPTAGSAKRRLFGEDPPKEMLMDKIITEGTKLKIAPSSSITAENVSILPGQTLLTMATAPVTGTTGHKVTIPLHGVANDAGEITLIPLSMNTNQESKVKSPVSLTAHSLIGASPKQTNLTKAQEVHSTGINRPKRTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFEFTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKTPDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYKFNGSPSKSLKDINNMIRQGEQRTKKRVIAIDSDAESPAKRVCQENDDVLLKRLQDVVSERANH","sequence_length":1068,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"3724c3ecfdda1990f2eae8c8182a3e64d34e3799b0c8d5112e16739fdff2ab91","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/P28749.json","taxon_id":"9606","uniprot_accession":"P28749","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf3452-pf11934.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11934","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf3452-pf11934.yaml"}],"pfam_ids":["PF01857","PF01858","PF11934"],"protein_name":"Retinoblastoma-like protein 2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MPSGGDQSPPPPPPPPAAAASDEEEEDDGEAEDAAPPAESPTPQIQQRFDELCSRLNMDEAARAEAWDSYRSMSESYTLEGNDLHWLACALYVACRKSVPTVSKGTVEGNYVSLTRILKCSEQSLIEFFNKMKKWEDMANLPPHFRERTERLERNFTVSAVIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPCTVSEIFHFCWVLFIYAKGNFPMISDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGLSEDFHAKDSKPSSDPPCIIEKLCSLHDGLVLEAKGIKEHFWKPYIRKLYEKKLLKGKEENLTGFLEPGNFGESFKAINKAYEEYVLSVGNLDERIFLGEDAEEEIGTLSRCLNAGSGTETAERVQMKNILQQHFDKSKALRISTPLTGVRYIKENSPCVTPVSTATHSLSRLHTMLTGLRNAPSEKLEQILRTCSRDPTQAIANRLKEMFEIYSQHFQPDEDFSNCAKEIASKHFRFAEMLYYKVLESVIEQEQKRLGDMDLSGILEQDAFHRSLLACCLEVVTFSYKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWKPESPLWEKIRDNENRVPTCEEVMPPQNLERADEICIAGSPLTPRRVTEVRADTGGLGRSITSPTTLYDRYSSPPASTTRRRLFVENDSPSDGGTPGRMPPQPLVNAVPVQNVSGETVSVTPVPGQTLVTMATATVTANNGQTVTIPVQGIANENGGITFFPVQVNVGGQAQAVTGSIQPLSAQALAGSLSSQQVTGTTLQVPGQVAIQQISPGGQQQKQGQSVTSSSNRPRKTSSLSLFFRKVYHLAAVRLRDLCAKLDISDELRKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQNIMRCYRTQPQARSQVYRSVLIKGKRKRRNSGSSDSRSHQNSPTELNKDRTSRDSSPVMRSSSTLPVPQPSSAPPTPTRLTGANSDMEEEERGDLIQFYNNIYIKQIKTFAMKYSQANMDAPPLSPYPFVRTGSPRRIQLSQNHPVYISPHKNETMLSPREKIFYYFSNSPSKRLREINSMIRTGETPTKKRGILLEDGSESPAKRICPENHSALLRRLQDVANDRGSH","sequence_length":1139,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"b0446cd59b6b28d5cce8fc61b9b065f697719d18f3fed972d8ed2032def83c10","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/Q08999.json","taxon_id":"9606","uniprot_accession":"Q08999","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/drm-complex-go0070176.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0070176","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/drm-complex-go0070176.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/myb-complex-go0031523.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0031523","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/myb-complex-go0031523.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/rb-e2f-complex-go0035189.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0035189","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/rb-e2f-complex-go0035189.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/eggshell-chorion-gene-amplification-go0007307.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0007307","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/eggshell-chorion-gene-amplification-go0007307.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/endomitotic-cell-cycle-go0007113.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0007113","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/endomitotic-cell-cycle-go0007113.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/negative-regulation-of-dna-replication-go0008156.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0008156","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/negative-regulation-of-dna-replication-go0008156.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/regulation-of-chromosome-segregation-go0051983.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0051983","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/regulation-of-chromosome-segregation-go0051983.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/regulation-of-execution-phase-of-apoptosis-go1900117.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1900117","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/regulation-of-execution-phase-of-apoptosis-go1900117.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/cyclin-box-found-in-retinoblastoma-associated-protein-rb-family-the-rb-cd20548.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd20548","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/cyclin-box-found-in-retinoblastoma-associated-protein-rb-family-the-rb-cd20548.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-a-box-ipr002720.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR002720","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-a-box-ipr002720.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-b-box-ipr002719.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR002719","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-b-box-ipr002719.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-n-terminal-ipr024599.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR024599","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-n-terminal-ipr024599.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/rb-a-pf01858.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF01858","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/rb-a-pf01858.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/rb-b-pf01857.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF01857","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/rb-b-pf01857.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/1-10-472-140-1-10-472-140.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:1.10.472.140","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/1-10-472-140-1-10-472-140.yaml"}],"pfam_ids":["PF01857","PF01858","PF11934"],"protein_name":"Retinoblastoma family protein","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSEPDPQELGAEVVSGLVATSDDRLEMINAEYTNLCRDLNMDRQTELQGYETYLEVSQRCSMEGTASHWMCCAIYTACRRTSTPTVTGQNAVVKGNCVSLNNLLRCCKMSIYEFKTKIKQWCDMANLPQEFVNEIEDLDRKFSITFMLHKRFRIIMDMIFSCPPNEKKHSKYISLHGNHAHGKCSYIKLDDICWRLFLCAKNQKPSNTVDLVTSYNLMICCIDLIYNNVLAEKRTDLINPKFEGLPSNWTELDFRHNPHCILSNFCDMTEEAKAMKATTFRQIMSSFFQASTIYGNKDTMLGLLANENFERNLKSLNISYEQYVLSVGEFDERILSAYDAGEHTALNDQSLRPPVTPLTRKQDLPAQPAMAGDKFEPVRNATNNVKQLSAFGRITEPTDFVKQAGEEVIAKLLSIIEEIEQKFLAKYPSTEAKSRFQLAKSFFFYLLDQILQAEIRNKPDIDLKRLLVQKVSLVIFNITLMACCVELVLEAYKTELKFPWVLDCFSISAFEFQKIIEIVVRHGSHEGCLNRSLIKHLNSIEETCLERLAWARNSTVWEMIASAQLPLPTWLMVNLDRAAGPLQIFLRKVYLLGWLRIQKLCSELSLCEKTPESIWHIFEHSITHETELMKDRHLDQNIMCAIYIYIRVKRMEDPKFSDIMRAYRNQPQAVNSVYREVFIDINEDGEPKVKDIIHFYNHTYVPLMRQFVIDYLNVTPDVSGRASDLQLSPHPKERAAQPKKVTQSHSLFVSQMSKNEIQQSPNQMVYSFCRSPAKDLQAMNEKVRGGKRMLSFGDEPGLGTMAETKRSKISQVKAVMDDPELQSAEQQTAVTTEGCVGGEGGEHET","sequence_length":845,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"b52cc01d915ac89ed5de06c380208da3c8d8044099a2e95871dbdba20013ead7","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q24472.json","taxon_id":"7227","uniprot_accession":"Q24472","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/drm-complex-go0070176.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0070176","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/drm-complex-go0070176.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/double-fertilization-forming-a-zygote-and-endosperm-go0009567.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0009567","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/double-fertilization-forming-a-zygote-and-endosperm-go0009567.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/embryo-sac-development-go0009553.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0009553","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/embryo-sac-development-go0009553.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/endosperm-development-go0009960.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0009960","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/endosperm-development-go0009960.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/gametophyte-development-go0048229.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0048229","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/gametophyte-development-go0048229.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/generative-cell-differentiation-go0022619.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0022619","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/generative-cell-differentiation-go0022619.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/guard-cell-fate-commitment-go0010377.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0010377","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/guard-cell-fate-commitment-go0010377.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/homologous-chromosome-pairing-at-meiosis-go0007129.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0007129","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/homologous-chromosome-pairing-at-meiosis-go0007129.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/negative-regulation-of-transcription-by-rna-polymerase-iii-go0016480.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0016480","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/negative-regulation-of-transcription-by-rna-polymerase-iii-go0016480.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/palisade-mesophyll-development-go1903866.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1903866","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/palisade-mesophyll-development-go1903866.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/regulation-of-dna-endoreduplication-go0032875.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0032875","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/regulation-of-dna-endoreduplication-go0032875.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/regulation-of-nuclear-division-go0051783.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0051783","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/regulation-of-nuclear-division-go0051783.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/regulation-of-stem-cell-population-maintenance-go2000036.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:2000036","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/regulation-of-stem-cell-population-maintenance-go2000036.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/trichome-morphogenesis-go0010090.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0010090","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/trichome-morphogenesis-go0010090.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/cyclin-box-found-in-arabidopsis-thaliana-retinoblastoma-related-protei-cd20601.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd20601","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/cyclin-box-found-in-arabidopsis-thaliana-retinoblastoma-related-protei-cd20601.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-a-box-ipr002720.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR002720","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-a-box-ipr002720.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-b-box-ipr002719.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR002719","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-b-box-ipr002719.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-n-terminal-ipr024599.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR024599","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/retinoblastoma-associated-protein-n-terminal-ipr024599.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/rb-a-pf01858.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF01858","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/rb-a-pf01858.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/rb-b-pf01857.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF01857","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/rb-b-pf01857.yaml"}],"pfam_ids":["PF01857","PF01858","PF11934"],"protein_name":"Retinoblastoma-related protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEEVQPPVTPPIEPNGKRSEASLLDICEKVLSLDGSTCDEALKLFTETKRILSASMSNIGSGTREEVERFWFAFILYSVKRLSVRKEADGLSVSGDNEFNLCQILRALKLNIVDFFKELPQFVVKAGSVLGELYGADWENRLQAKEVQANFVHLSLLSKYYKRGFREFFLTYDANAEKNSANSSTYLLDSYRFGWLLFLALRNHAFSRFKDLVTCSNGVVSILAILIIHVPCRFRNFSIQDSSRFVKKGDKGVDLVASLCKIYDASEDELRIVIDKANNLVETILKKKPSPASECQTDKLDNIDPDGLTYFEDLLEETSISTSLITLEKDYYDGKGELDERVFINEEDSLLGSGSLSAGAVNITGVKRKIDALSSPARTFISPLSPHKSPAAKTNGISGATKLAATPVSTAMTTAKWLRTVISPLLPKPSPGLEHFLKSCDRDITNDVTRRAHIILEAIFPNSSLGAQCGGGSLQAVDLMDDIWAEQRRLEACKLYYRVLEAMCKAEAQILHANNLNSLLTNERFHRCMLACSAELVLATHKTITMLFPAVLERTGITAFDLSKVIESFIRHEDSLPRELRRHLNSLEERLLESMVWEKGSSMYNSLIVARPSLALEINQLGLLAEPMPSLDAIAALINFSDGANHASSVQKHETCPGQNGGIRSPKRLCTDYRSILVERNSFTSPVKDRLLALGNVKSKMLPPPLQSAFASPTRPNPGGGGETCAETGINIFFTKINKLAAVRINGMVERLQLSQQIRESVYCFFQHVLAQRTSLLFSRHIDQIILCCFYGVAKISQMSLTFREIIYNYRKQPQCKPLVFRSVYVDALQCRRQGRIGPDHVDIITFYNEIFIPAVKPLLVELGPVRNDRAVEANNKPEGQCPGSPKVSVFPSVPDMSPKKVSAVHNVYVSPLRGSKMDALISHSTKSYYACVGESTHAYQSPSKDLSAINNRLNNSSSNRKRTLNFDAEAGMVSDSMVANSLNLQNQNQNQNGSDASSSGGAAPLKTEPTDS","sequence_length":1013,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"5bddb09ce6741c6dfdc6cd013a6453e8662ff148f4ba4e52e43ed42e51218234","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9LKZ3.json","taxon_id":"3702","uniprot_accession":"Q9LKZ3","uniprot_release":"2026_03"}],"pfam_id":"PF11934","short_name":"DUF3452","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}