{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11944","protein_label":"UPF0325 protein YaeH","reviewed":true,"short_name":"DUF3461","source_category":"function/protein_family/ncbifam","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/protein_family/ncbifam/duf3461-family-protein-nf010213.yaml","source_record_id":"NCBIfam:NF010213","source_record_label":"DUF3461 family protein","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P62768","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11944","protein_label":"UPF0325 protein AHA_1169","reviewed":true,"short_name":"DUF3461","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3461-pf11944.yaml","source_record_id":"Pfam:PF11944","source_record_label":"Protein of unknown function (DUF3461)","source_section":"canonical_examples","taxon_id":"NCBITaxon:380703","taxon_label":"Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)","uniprot_accession":"A0KHF9","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11944","protein_label":"UPF0325 protein YE3288","reviewed":true,"short_name":"DUF3461","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3461-pf11944.yaml","source_record_id":"Pfam:PF11944","source_record_label":"Protein of unknown function (DUF3461)","source_section":"canonical_examples","taxon_id":"NCBITaxon:393305","taxon_label":"Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)","uniprot_accession":"A1JP87","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF11944","protein_label":"UPF0325 protein YaeH","reviewed":true,"short_name":"DUF3461","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3461-pf11944.yaml","source_record_id":"Pfam:PF11944","source_record_label":"Protein of unknown function (DUF3461)","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P62768","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF11944","protein_label":"","reviewed":null,"short_name":"DUF3461","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3461-pf11944.yaml","source_record_id":"Pfam:PF11944","source_record_label":"Protein of unknown function (DUF3461)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":642,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":2},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 130 amino acids in length. This protein has two conserved sequence motifs: KFK and HLE.","domain_architectures":2,"interpro_id":"IPR020911","known_evidence_count":null,"matches":926,"name":"Protein of unknown function (DUF3461)","partial_evidence_count":null,"pfam_id":"PF11944","proteins":924,"proteomes":844,"short_name":"DUF3461","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11944","structures":0,"taxa":1256,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF11944.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":642,"domain_architectures":2,"matches":926,"proteins":924,"proteomes":844,"structures":0,"taxa":1256},"curation_status":"SEEDED","description":"This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 130 amino acids in length. This protein has two conserved sequence motifs: KFK and HLE.","id":"Pfam:PF11944","interpro_id":"InterPro:IPR020911","name":"Protein of unknown function (DUF3461)","pfam_id":"PF11944","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF3461","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11944"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF11944.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"a0d4db6fdce3181098c1d08f0c1d7b5fcf512724844eac6dd719357cfbd3c600"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf3461-pf11944.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11944","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf3461-pf11944.yaml"}],"pfam_ids":["PF11944"],"protein_name":"UPF0325 protein AHA_1169","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MYENLKSLGIQEPTSVDSYTLRQEANHDILKIYFKKQKGEFFAKSVKFKYPRQRKTMLVDSGTHEYKDVTEINANLKYVVDELDNLTQGVHVQADPDIKQKILRDLRHLEKVVQNKISEIERDLEKL","sequence_length":127,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"5c8ce2f16826ee00e24719048b69817ca330950a7962feda814b8eb352ca1456","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A0KHF9.json","taxon_id":"380703","uniprot_accession":"A0KHF9","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf3461-pf11944.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11944","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf3461-pf11944.yaml"}],"pfam_ids":["PF11944"],"protein_name":"UPF0325 protein YE3288","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MYDNLKSLGITQPEDVDRYSLRQEANNDILKIYFRKDKGEFFAKSVKFKYPRQRKTVVADNAGHGYKEINEINPNLRYVIDELDQLCKRDQVEVDLKRKILDDLRHLESVVTNKIAEIEADLEKLTSGR","sequence_length":129,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"37dd46fed5eb79333ebd85ea30a30b2dd1c8d8aa6acd89b8b59e3eeb7f6a6282","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A1JP87.json","taxon_id":"393305","uniprot_accession":"A1JP87","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/duf3461-family-protein-nf010213.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF010213","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/duf3461-family-protein-nf010213.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf3461-pf11944.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11944","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf3461-pf11944.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P62768","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF11944"],"protein_name":"UPF0325 protein YaeH","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"c8153a787f23bd052575012255885835a82d46bb246943458e74f088ee288a5a","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MYDNLKSLGITNPEEIDRYSLRQEANNDILKIYFQKDKGEFFAKSVKFKYPRQRKTVVADGVGQGYKEVQEISPNLRYIIDELDQICQRDRSEVDLKRKILDDLRHLESVVTNKISEIEADLEKLTRK","sequence_length":128,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"c8153a787f23bd052575012255885835a82d46bb246943458e74f088ee288a5a","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P62768.json","taxon_id":"83333","uniprot_accession":"P62768","uniprot_release":"2026_03"}],"pfam_id":"PF11944","short_name":"DUF3461","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}