{"cross_mech":[],"family":{"alphafold_models":4830,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain can be found at the N terminus of TgpA from Pseudomonas aeruginosa. TgpA is a transglutaminase that plays a critical role in the viability of Pseudomonas aeruginosa [[cite:PUB00092521],[cite:PUB00092522]]. This domain is composed of 5 transmembrane helices [[cite:PUB00092522]].","domain_architectures":19,"interpro_id":"IPR021878","known_evidence_count":null,"matches":8195,"name":"TgpA N-terminal domain","partial_evidence_count":null,"pfam_id":"PF11992","proteins":8161,"proteomes":6697,"short_name":"TgpA_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11992","structures":2,"taxa":9425,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF11992.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":4830,"domain_architectures":19,"matches":8195,"proteins":8161,"proteomes":6697,"structures":2,"taxa":9425},"curation_status":"SEEDED","description":"This domain can be found at the N terminus of TgpA from Pseudomonas aeruginosa. TgpA is a transglutaminase that plays a critical role in the viability of Pseudomonas aeruginosa [[cite:PUB00092521],[cite:PUB00092522]]. This domain is composed of 5 transmembrane helices [[cite:PUB00092522]].","id":"Pfam:PF11992","interpro_id":"InterPro:IPR021878","name":"TgpA N-terminal domain","pfam_id":"PF11992","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"TgpA_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11992"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF11992.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"c6610fe0c2f483bfafff8a5fa65bd4dc9ecb43ba4eb37724bfc38e7456c85946"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-glutamine-gamma-glutamyltransferase-like-c-terminal-ipr025403.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR025403","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-glutamine-gamma-glutamyltransferase-like-c-terminal-ipr025403.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/protein-glutamine-gamma-glutamyltransferase-tgpa-n-terminal-ipr021878.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR021878","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/protein-glutamine-gamma-glutamyltransferase-tgpa-n-terminal-ipr021878.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf4129-pf13559.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF13559","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf4129-pf13559.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/tgpa-n-pf11992.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF11992","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/tgpa-n-pf11992.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/3-10-620-30-3-10-620-30.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.10.620.30","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/3-10-620-30-3-10-620-30.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P94476","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF01841","PF11992","PF13559"],"protein_name":"Uncharacterized protein YebA","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"44fa5108722cf9cdeb4f8584e4c8d299084e9128f80d10660a86fa71bae58a02","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFSVFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNITLIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFTPYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFGLAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQGKERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKHYGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYKLDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYLGSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGYTSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKDSGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAVLAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSETLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS","sequence_length":737,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"44fa5108722cf9cdeb4f8584e4c8d299084e9128f80d10660a86fa71bae58a02","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P94476.json","taxon_id":"224308","uniprot_accession":"P94476","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf4129-pf13559.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF13559","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf4129-pf13559.yaml"}],"pfam_ids":["PF01841","PF11992","PF13559"],"protein_name":"Protein-glutamine gamma-glutamyltransferase","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNAIPRVALVWLLVAQVLVILPHLAYMPLWIAAMWLGCAAWRVQVFRMRAGYPRAWVKLALALLAGAGVWLSRGSLVGLDAGAVLLIAAFILKLVEMKTRRDALVLVFLGFFAVVVGYLFDDGFLAALYSLLPVTALLAALIGLQQSAFASRPWPTLRLAGGLLLQALPLMLLLFLFFPRLGPLWSLPMPGNKGVTGLSESMAPGDIAELGRSAELAFRVRFEGALPPREQLYWRALTMERFDGRRWAQAPQWSGEDALHWQKRGPELRYDVIMQPSSQPWLFALDVAQTDQTDTRLMSDFHLQRRQPVEQRLFYRVSSWPQALRESSIDPRTRWRNLQLPMHGNPRARALADELRQAHAQPQALVAALLQRFNHEPFAYTLKPPATGADGVDDFLFDTRSGFCAHYAGAMAFVLRAAGIPARVVAGYQGGELNPAGNYLLVHQFDAHAWVEYWQPEQGWLSVDPTYQVAPERIEQGLEQALAGDSEYLADAPLSPLRYRGLPWLNDMRLAWDSLNYGWQRWVLAYQGEQQGAFLQRWFGGLDPTRLGLLLGAAAILSVGLLALFLLKPWQGRGDLRSRQLRRFERLLEMHGLRRSPGEGLRSYGERAARVLPAQAPAIAAFVGAFEAQRYGHGGADDPGLRLRALRRALPWRLVRTPTRDGRGEEQA","sequence_length":668,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"0ef035cbbcb6d05ceb44de0a79c0296ec1e93fafd3fff0368a8c98d6c7a80252","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9HZX3.json","taxon_id":"208964","uniprot_accession":"Q9HZX3","uniprot_release":"2026_03"}],"pfam_id":"PF11992","short_name":"TgpA_N","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
