{"cross_mech":[],"family":{"alphafold_models":10,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents the first region from the so-called delivery domain from Lymphostatin. Lymphostatin is a key virulence factor of enteropathogenic and enterohaemorrhagic Escherichia coli, playing roles in bacterial colonisation of the gut and in the inhibition of lymphocyte proliferation and proinflammatory responses [[cite:PUB00164033]]. Lymphostatin is composed of six distinct domains which enable complex interactions with host cells. These domains include two glycosyltransferase domains, one PaToxP-like protease domain, an ADP-ribosyltransferase domain, a vertex domain and a delivery domain [[cite:PUB00164033]]. The delvery domain is involved in the receptor binding and translocation. It is an evolutionary conserved translocation and delivery apparatus in LCT-like toxins [[cite:PUB00164033]]. The delivery domain shows some flexibility and can adopt different conformations.","domain_architectures":10,"interpro_id":"IPR021882","known_evidence_count":null,"matches":50,"name":"Lymphostatin, delivery I domain","partial_evidence_count":null,"pfam_id":"PF11996","proteins":44,"proteomes":19,"short_name":"Lymphostatin_delI","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11996","structures":5,"taxa":75,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF11996.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":10,"domain_architectures":10,"matches":50,"proteins":44,"proteomes":19,"structures":5,"taxa":75},"curation_status":"SEEDED","description":"This entry represents the first region from the so-called delivery domain from Lymphostatin. Lymphostatin is a key virulence factor of enteropathogenic and enterohaemorrhagic Escherichia coli, playing roles in bacterial colonisation of the gut and in the inhibition of lymphocyte proliferation and proinflammatory responses [[cite:PUB00164033]]. Lymphostatin is composed of six distinct domains which enable complex interactions with host cells. These domains include two glycosyltransferase domains, one PaToxP-like protease domain, an ADP-ribosyltransferase domain, a vertex domain and a delivery domain [[cite:PUB00164033]]. The delvery domain is involved in the receptor binding and translocation. It is an evolutionary conserved translocation and delivery apparatus in LCT-like toxins [[cite:PUB00164033]]. The delivery domain shows some flexibility and can adopt different conformations.","id":"Pfam:PF11996","interpro_id":"InterPro:IPR021882","name":"Lymphostatin, delivery I domain","pfam_id":"PF11996","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Lymphostatin_delI","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF11996"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF11996.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"8e57a384e4a5e10f1160b5373fe90ec6cb30a725b210e84ac397da5a14d94574"}},"protein_examples":{"candidate_count":0,"discovery_scanned":true,"example_count":0,"examples":[],"pfam_id":"PF11996","short_name":"Lymphostatin_delI","status":"NO_SIBLING_CANDIDATE","unresolved":[]}}