{"cross_mech":[],"family":{"alphafold_models":1404,"candidate_reasons":["name_says_unknown_function","domain_of_unknown_function","pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found FAP206 [swissprot:Q23H79], a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule [[cite:PUB00082324]].","domain_architectures":28,"interpro_id":"IPR021897","known_evidence_count":null,"matches":1641,"name":"Domain of unknown function","partial_evidence_count":null,"pfam_id":"PF12018","proteins":1601,"proteomes":1224,"short_name":"FAP206","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12018","structures":1,"taxa":4024,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF12018.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1404,"domain_architectures":28,"matches":1641,"proteins":1601,"proteomes":1224,"structures":1,"taxa":4024},"curation_status":"SEEDED","description":"This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found FAP206 [swissprot:Q23H79], a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule [[cite:PUB00082324]].","id":"Pfam:PF12018","interpro_id":"InterPro:IPR021897","name":"Domain of unknown function","pfam_id":"PF12018","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"FAP206","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12018"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF12018.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"5364ca44392d434e883c856dfe777254e81c8924afec4937c43b4f4f8c1a2d32"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Tetrahymena thermophila (strain SB210)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/fap206-pf12018.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12018","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/fap206-pf12018.yaml"}],"pfam_ids":["PF12018"],"protein_name":"Cilia- and flagella-associated protein 206","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNQLEEIVKYVIYKCRENNHPVTETLAAFVTQTIYNPKTDRFYLEDKLTASQVDELKATVLQKLSQIDKPNMKTIQMQISYDSAYIESEIQRQERIKNQSIETGKLTDEVVSLEIKNAKDFEGLTVLFKKIFNFLLYKNKELMYDGTNKTGNQDSENQATQFNIEKEVAAGLESVIPRAALGPFVSLNPSEKVTQLVELSNLVIGIRLFNKWIQKGGIGLVPFQDLLEYEGRDLIERIRQEAFEVIENCDNYTIFFQNVGPGKIKISDEQFKQYKDELTFLRQYLSYILSIQEDVDISENSVDSNQTRYLKEIKDLETLLKQKSSAPKEQVYPKFATLAQAYIQLLEEKKLCLTRVKLFELLQEMRKGFKLTLPRNLILTAKNISQDPSNEEQVEIEYSEDCGIERLLPKNTPDFMQTPLDYLGFCLWSIVKRDGLLLPGKPALGVFRYKDKNCVFSDEKSINEFLSDPQQFIQGVINQCRKNPELIHLLRMDDSFKNVNLNIYVSGQEGGHQLSNKLMVDKGIETPLHFVEKRLDPNYCWNEWELRKKALQMANIRKRQTKACQTILSNFKVDSEAQTYLPKDNETNTGKTEWDIRKFAIEQAKKKGIIAGTDRAPYPIHPRNYITGLRDKDTN","sequence_length":635,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"1ef33d4f9a6600e82efa67db88b1b12d85e36ee58a14b84cfd0379e66b28042b","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q23H79.json","taxon_id":"312017","uniprot_accession":"Q23H79","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/radial-spoke-go0001534.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0001534","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/radial-spoke-go0001534.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/regulation-of-cilium-beat-frequency-go0003356.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0003356","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/regulation-of-cilium-beat-frequency-go0003356.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/regulation-of-flagellated-sperm-motility-go1901317.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1901317","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/regulation-of-flagellated-sperm-motility-go1901317.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/fap206-pf12018.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12018","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/fap206-pf12018.yaml"}],"pfam_ids":["PF12018"],"protein_name":"Cilia- and flagella-associated protein 206","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MPPTQAESVIKNIIREIGQECAAHGEIASETVVAFMVKAVVLDPSNGFNMDRTLIKTDVQKLVKLCVARLLDNKNPSLDTIKMQVYFDMNYTSREDFLEEHHRVLESRLGIVSREITDNRASAREELENLYRKIVSYVLLRSGLGSPTDIKIVREATAALQSVFPQAELATFLTLSKKDKERQLKELTMIVTGIRLFNRDCGKGGEGIDDLPAILHEAIPTTTQHIDSQLQIAQDQAFRYTAILEKVTNNPLMAKELQPYMLKEALYNVRQYEIFLQTVLSDIITCAEEVEMMIKQLAAQLEQLKMAVKSKTAVPTSQVFPIFVALASLWMSFQDETVLISVLSNLTTNLELFLGTHELLFPEKVMLGLLDGVVVKSDLTRIEEHMEERVELADFRTQEWLFPETTANFNKLLIQYRGFCGYTFAVTDGLLLPGNPAIGILKYKEKYYTFSTRDAAYTFAENPDHYIHLIKEKAKKNAELIQLLELHQQFETLIPYSQMRDVDKHYIKPITKCDNGTQTDTHILPPTTMRTYEWNEWELRRKAIKLANLRQKITHSVQTDLSHMRRDNTSQVYPLKEASTQSKREGSSRVPRPQIFIAGLRGGQSKTTYGVKVNLTRAVDET","sequence_length":622,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"9bad510714b55da569aeb089044b7765a5adb13d0ea74404dd07b0200394b14f","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q6PE87.json","taxon_id":"10090","uniprot_accession":"Q6PE87","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/radial-spoke-go0001534.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0001534","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/radial-spoke-go0001534.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/regulation-of-cilium-beat-frequency-go0003356.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0003356","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/regulation-of-cilium-beat-frequency-go0003356.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/regulation-of-flagellated-sperm-motility-go1901317.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1901317","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/regulation-of-flagellated-sperm-motility-go1901317.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/fap206-pf12018.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12018","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/fap206-pf12018.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q8IYR0","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF12018"],"protein_name":"Cilia- and flagella-associated protein 206","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"66c9f19126fadc7c3d36a206d3a821c8d252e38b92995cf8bdaef4c14e95d460","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MPPTQAESVIRSIIREIGQECAAHGEIVSETLIAFMVKAVVLDPSNGFNMDRTLMKSDVQNLVKLCMTRLLDTKNPSLDTIKMQVYFDMNYTNRVEFLEEHHRVLESRLGSVTREITDNRACAKEELESLYRKIISYVLLRSGLGSPTDIKTVREVTAALQSVFPQAELGTFLTLSKKDKERQLKELTMIVTGIRLFNRDCGKGGEGIDDLPAVLHVAIPATMQHIDYQLETARSQVYRYTAILEKAANDPLMRAELQPYMLKEALYNIRQYEVFLQIILSDIITGAQEVEMMTKQLGAHLEQLKMTIKSKIAVPTSQVFPIFIALSTLWTSLQDETIVVGVLSNLFTHIQPFLGAHELYFPERVMQCHLNGATVKTDVCRMKEHMEDRVNVADFRKLEWLFPETTANFDKLLIQYRGFCAYTFAATDGLLLPGNPAIGILKYKEKYYTFNSKDAAYSFAENPEHYIDIVREKAKKNTELIQLLELHQQFETFIPYSQMRDADKHYIKPITKCESSTQTNTHILPPTIVRSYEWNEWELRRKAIKLANLRQKVTHSVQTDLSHLRRENCSQVYPPKDTSTQSMREDSTGVPRPQIYLAGLRGGKSEITDEVKVNLTRDVDET","sequence_length":622,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"66c9f19126fadc7c3d36a206d3a821c8d252e38b92995cf8bdaef4c14e95d460","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q8IYR0.json","taxon_id":"9606","uniprot_accession":"Q8IYR0","uniprot_release":"2026_03"}],"pfam_id":"PF12018","short_name":"FAP206","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}