{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12036","protein_label":"Protein myomaker","reviewed":true,"short_name":"DUF3522","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/myoblast-fusion-involved-in-skeletal-muscle-regeneration-go0014905.yaml","source_record_id":"GO:0014905","source_record_label":"myoblast fusion involved in skeletal muscle regeneration","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q9D1N4","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12036","protein_label":"Protein myomaker","reviewed":true,"short_name":"DUF3522","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/positive-regulation-of-skeletal-muscle-hypertrophy-go1904206.yaml","source_record_id":"GO:1904206","source_record_label":"positive regulation of skeletal muscle hypertrophy","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"A6NI61","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12036","protein_label":"Protein myomaker","reviewed":true,"short_name":"DUF3522","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/positive-regulation-of-skeletal-muscle-hypertrophy-go1904206.yaml","source_record_id":"GO:1904206","source_record_label":"positive regulation of skeletal muscle hypertrophy","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q9D1N4","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12036","protein_label":"Transmembrane protein 8B","reviewed":true,"short_name":"DUF3522","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3522-pf12036.yaml","source_record_id":"Pfam:PF12036","source_record_label":"Protein of unknown function (DUF3522)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"A6NDV4","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12036","protein_label":"Protein myomaker","reviewed":true,"short_name":"DUF3522","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3522-pf12036.yaml","source_record_id":"Pfam:PF12036","source_record_label":"Protein of unknown function (DUF3522)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"A6NI61","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12036","protein_label":"Post-GPI attachment to proteins factor 6","reviewed":true,"short_name":"DUF3522","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3522-pf12036.yaml","source_record_id":"Pfam:PF12036","source_record_label":"Protein of unknown function (DUF3522)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q9HCN3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF12036","protein_label":"","reviewed":null,"short_name":"DUF3522","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3522-pf12036.yaml","source_record_id":"Pfam:PF12036","source_record_label":"Protein of unknown function (DUF3522)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":3868,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":4,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":3},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family of proteins is functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 220 to 787 amino acids in length. This family belongs to the CREST superfamily [[cite:PUB00085069]], which are distant members of the GPCR superfamily.","domain_architectures":51,"interpro_id":"IPR021910","known_evidence_count":null,"matches":4599,"name":"Protein of unknown function (DUF3522)","partial_evidence_count":null,"pfam_id":"PF12036","proteins":4473,"proteomes":1621,"short_name":"DUF3522","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12036","structures":5,"taxa":5007,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF12036.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3868,"domain_architectures":51,"matches":4599,"proteins":4473,"proteomes":1621,"structures":5,"taxa":5007},"curation_status":"SEEDED","description":"This family of proteins is functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 220 to 787 amino acids in length. This family belongs to the CREST superfamily [[cite:PUB00085069]], which are distant members of the GPCR superfamily.","id":"Pfam:PF12036","interpro_id":"InterPro:IPR021910","name":"Protein of unknown function (DUF3522)","pfam_id":"PF12036","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF3522","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12036"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF12036.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"f0111351853f1ff9c9d21c8a7f656de8f87c05384eabea77d0203540212d29af"}},"protein_examples":{"candidate_count":4,"discovery_scanned":true,"example_count":4,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf3522-pf12036.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12036","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf3522-pf12036.yaml"}],"pfam_ids":["PF12036","PF31127"],"protein_name":"Transmembrane protein 8B","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNMPQSLGNQPLPPEPPSLGTPAEGPGTTSPPEHCWPVRPTLRNELDTFSVHFYIFFGPSVALPPERPAVFAMRLLPVLDSGGVLSLELQLNASSVRQENVTVFGCLTHEVPLSLGDAAVTCSKESLAGFLLSVSATTRVARLRIPFPQTGTWFLALRSLCGVGPRFVRCRNATAEVRMRTFLSPCVDDCGPYGQCKLLRTHNYLYAACECKAGWRGWGCTDSADALTYGFQLLSTLLLCLSNLMFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDQPGIVVFCIMDYDVLQFCDFLGSLMSVWVTVIAMARLQPVVKQVLYLLGAMLLSMALQLDRHGLWNLLGPSLFALGILATAWTVRSVRRRHCYPPTWRRWLFYLCPGSLIAGSAVLLYAFVETRDNYFYIHSIWHMLIAGSVGFLLPPRAKTDHGVPSGARARGCGYQLCINEQEELGLVGPGGATVSSICAS","sequence_length":472,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"6070c4e0603ffd36b9dbb487540e15cd34926198ecfe789b099d32a24b1db61f","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/A6NDV4.json","taxon_id":"9606","uniprot_accession":"A6NDV4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/positive-regulation-of-skeletal-muscle-hypertrophy-go1904206.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1904206","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/positive-regulation-of-skeletal-muscle-hypertrophy-go1904206.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf3522-pf12036.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12036","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf3522-pf12036.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:A6NI61","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF12036"],"protein_name":"Protein myomaker","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"3c577235ee6437de8980bd7a4490ce42c359d95187e55bec3a084c89e687b18d","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MGTLVAKLLLPTLSSLAFLPTVSIAAKRRFHMEAMVYLFTLFFVALHHACNGPGLSVLCFMRHDILEYFSVYGTALSMWVSLMALADFDEPKRSTFVMFGVLTIAVRIYHDRWGYGVYSGPIGTAILIIAAKWLQKMKEKKGLYPDKSVYTQQIGPGLCFGALALMLRFFFEDWDYTYVHSFYHCALAMSFVLLLPKVNKKAGSPGTPAKLDCSTLCCACV","sequence_length":221,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"3c577235ee6437de8980bd7a4490ce42c359d95187e55bec3a084c89e687b18d","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A6NI61.json","taxon_id":"9606","uniprot_accession":"A6NI61","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/myoblast-fusion-involved-in-skeletal-muscle-regeneration-go0014905.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0014905","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/myoblast-fusion-involved-in-skeletal-muscle-regeneration-go0014905.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/positive-regulation-of-skeletal-muscle-hypertrophy-go1904206.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:1904206","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/positive-regulation-of-skeletal-muscle-hypertrophy-go1904206.yaml"}],"pfam_ids":["PF12036"],"protein_name":"Protein myomaker","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGTVVAKLLLPTLSSLAFLPTVSIATKRRFYMEAMVYLFTMFFVAFSHACDGPGLSVLCFMRRDILEYFSIYGTALSMWVSLMALADFDEPQRSTFTMLGVLTIAVRTFHDRWGYGVYSGPIGTATLIIAVKWLKKMKEKKGLYPDKSIYTQQIGPGLCFGALALMLRFFFEEWDYTYVHSFYHCALAMSFVLLLPKVNKKAGNAGAPAKLTFSTLCCTCV","sequence_length":221,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"90df9690c757064d4ceaca98663f1f63fdc8a78faf6c9be52f81a46f7b9a8797","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9D1N4.json","taxon_id":"10090","uniprot_accession":"Q9D1N4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf3522-pf12036.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12036","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf3522-pf12036.yaml"}],"pfam_ids":["PF12036","PF31127"],"protein_name":"Post-GPI attachment to proteins factor 6","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGRAGTGTGGEAVAAVVAGPLLLLLLARPPPASAGYSGKSEVGLVSEHFSQAPQRLSFYSWYGSARLFRFRVPPDAVLLRWLLQVSRESGAACTDAEITVHFRSGAPPVINPLGTSFPDDTAVQPSFQVGVPLSTTPRSNASVNVSHPAPGDWFVAAHLPPSSQKIELKGLAPTCAYVFQPELLVTRVVEISIMEPDVPLPQTLLSHPSYLKVFVPDYTRELLLELRDCVSNGSLGCPVRLTVGPVTLPSNFQKVLTCTGAPWPCRLLLPSPPWDRWLQVTAESLVGPLGTVAFSAVAALTACRPRSVTIQPLLQSSQNQSFNASSGLLSPSPDHQDLGRSGRVDRSPFCLTNYPVTREDMDVVSVHFQPLDRVSVRVCSDTPSVMRLRLNTGMDSGGSLTISLRANKTEMRNETVVVACVNAASPFLGFNTSLNCTTAFFQGYPLSLSAWSRRANLIIPYPETDNWYLSLQLMCPENAEDCEQAVVHVETTLYLVPCLNDCGPYGQCLLLRRHSYLYASCSCKAGWRGWSCTDNSTAQTVAQQRAATLLLTLSNLMFLAPIAVSVRRFFLVEASVYAYTMFFSTFYHACDQPGEAVLCILSYDTLQYCDFLGSGAAIWVTILCMARLKTVLKYVLFLLGTLVIAMSLQLDRRGMWNMLGPCLFAFVIMASMWAYRCGHRRQCYPTSWQRWAFYLLPGVSMASVGIAIYTSMMTSDNYYYTHSIWHILLAGSAALLLPPPDQPAEPWACSQKFPCHYQICKNDREELYAVT","sequence_length":771,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"476b2aadec41bdef484c48d67ab5a0cffc85b498db138974c66d2dc3d7915940","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/Q9HCN3.json","taxon_id":"9606","uniprot_accession":"Q9HCN3","uniprot_release":"2026_03"}],"pfam_id":"PF12036","short_name":"DUF3522","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}