{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12064","protein_label":"MYND-type zinc finger-containing chromatin reader ZMYND8","reviewed":true,"short_name":"DUF3544","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/zmynd8-cc-pf23460.yaml","source_record_id":"Pfam:PF23460","source_record_label":"ZMYND8 protein coiled-coil","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q9ULU4","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12064","protein_label":"MYND-type zinc finger-containing chromatin reader ZMYND8","reviewed":true,"short_name":"DUF3544","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3544-pf12064.yaml","source_record_id":"Pfam:PF12064","source_record_label":"Protein kinase C-binding protein 1","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q9ULU4","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF12064","protein_label":"","reviewed":null,"short_name":"DUF3544","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3544-pf12064.yaml","source_record_id":"Pfam:PF12064","source_record_label":"Protein kinase C-binding protein 1","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"KNOWN_HISTORICAL_DUF"}],"family":{"alphafold_models":2827,"candidate_reasons":["short_name_matches_duf"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":1,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":2},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is a domain found predominantly in eukaryotes and associated with [pfam:PF00628] [pfam:PF01753] [pfam:PF00439] [pfam:PF00855]. Family members include protein kinase C-binding protein 1 (also known as ZMYND8) which acts as a transcriptional corepressor of the H3K4 demethylase JARID1D [[cite:PUB00085454]]. ZMYND8 (zinc finger and MYND [myeloid, Nervy, and DEAF-1] domain containing 8) binds acetylated damaged chromatin, including actively transcribed regions, as a means of recruiting the nucleosome remodeling and histone deacetylation (NuRD) chromatin remodeling complex for transcriptional repression and DNA double-strand break (DSB) repair by homologous recombination (HR) [[cite:PUB00103635]].","domain_architectures":30,"interpro_id":"IPR021931","known_evidence_count":null,"matches":3369,"name":"Protein kinase C-binding protein 1","partial_evidence_count":null,"pfam_id":"PF12064","proteins":3284,"proteomes":702,"short_name":"DUF3544","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12064","structures":0,"taxa":2145,"unknown_status":"KNOWN_HISTORICAL_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF12064.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2827,"domain_architectures":30,"matches":3369,"proteins":3284,"proteomes":702,"structures":0,"taxa":2145},"curation_status":"SEEDED","description":"This is a domain found predominantly in eukaryotes and associated with [pfam:PF00628] [pfam:PF01753] [pfam:PF00439] [pfam:PF00855]. Family members include protein kinase C-binding protein 1 (also known as ZMYND8) which acts as a transcriptional corepressor of the H3K4 demethylase JARID1D [[cite:PUB00085454]]. ZMYND8 (zinc finger and MYND [myeloid, Nervy, and DEAF-1] domain containing 8) binds acetylated damaged chromatin, including actively transcribed regions, as a means of recruiting the nucleosome remodeling and histone deacetylation (NuRD) chromatin remodeling complex for transcriptional repression and DNA double-strand break (DSB) repair by homologous recombination (HR) [[cite:PUB00103635]].","id":"Pfam:PF12064","interpro_id":"InterPro:IPR021931","name":"Protein kinase C-binding protein 1","pfam_id":"PF12064","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"KNOWN_HISTORICAL_DUF","short_name":"DUF3544","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12064"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF12064.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"c7ca667ed99de2ec1c6833df9c0d5a164aab8ff239c2e97fff4b3d90eca2b7f0"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/zmynd8-cc-pf23460.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF23460","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/zmynd8-cc-pf23460.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf3544-pf12064.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12064","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf3544-pf12064.yaml"}],"pfam_ids":["PF00439","PF00628","PF00855","PF12064","PF23460","PF24324"],"protein_name":"MYND-type zinc finger-containing chromatin reader ZMYND8","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQGSDHSRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESRLDTFWD","sequence_length":1186,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"78c6bdb417ce3dc0658b9f79fd5c5f351c2e72fa2c7bd259125eabf50dffd884","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q9ULU4.json","taxon_id":"9606","uniprot_accession":"Q9ULU4","uniprot_release":"2026_03"}],"pfam_id":"PF12064","short_name":"DUF3544","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}