{"cross_mech":[],"family":{"alphafold_models":2971,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"SCAI is a transcriptional cofactor and tumour suppressor that suppresses MKL1-induced SRF transcriptional activity. It may function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1 [[cite:PUB00068364]].","domain_architectures":51,"interpro_id":"IPR022709","known_evidence_count":null,"matches":3823,"name":"Protein SCAI","partial_evidence_count":null,"pfam_id":"PF12070","proteins":3464,"proteomes":1682,"short_name":"SCAI","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12070","structures":0,"taxa":5209,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF12070.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2971,"domain_architectures":51,"matches":3823,"proteins":3464,"proteomes":1682,"structures":0,"taxa":5209},"curation_status":"SEEDED","description":"SCAI is a transcriptional cofactor and tumour suppressor that suppresses MKL1-induced SRF transcriptional activity. It may function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1 [[cite:PUB00068364]].","id":"Pfam:PF12070","interpro_id":"InterPro:IPR022709","name":"Protein SCAI","pfam_id":"PF12070","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"SCAI","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12070"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF12070.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"1bd3dbdfdb5286b85bea7027d7d1aaf3f907c71693132de603f8b3ee331c8ae0"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/scai-pf12070.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12070","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/scai-pf12070.yaml"}],"pfam_ids":["PF12070"],"protein_name":"Protein SCAI","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MVRGARQSQQPRSRLAPRLSGTVEKPPRKRKSRTEFTLKETMSSGGAEDDIPQGERKTVTDFCYLLDKSKQLFNGLRDLPQYGQKQWQSYFGRTFDVYTKLWKFQQQHRQVLDNRYGLKRWQIGEIASKIGQLYYHYYLRTSETSYLNEAFSFYSAIRQRSYYSQVNKEDRPELVVKKLRYYARFIVVCLLLNKMDVVKDLVKELSDEIEDYTHRFNTEDQVEWNLVLQEVAAFIEADPVMVLNDDNTIVITSNRLAETGAPLLEQGMIVGQLSLADALIIGNCNNQVKFSELTVDMFRMLQALEREPMNLASQMNKPGIQEPADKPTRRENPHKYLLYKPTFSQLYTFLAASFKELPANSVLLIYLSATGVFPTGRSDGEGPYDFGGVLTNSNRDIINGDAIHKRNQSHKEMHCLHPGDLYPFTRKPLFIVVDSSNSVAYKNFTNLFGQPLVCLLSPTAYPKALQDQSQRGSLFTLFLNNPLMAFLFVSGLSSMRRGLWEKCQEYLRKINRDIAQLLTHSRSIDQAFLQFFGDEFLRLLLTRFVFCSATMRMHKAFRETRNYPESYPQLPRDETVENPHLQKHILELASILDVRNIFFENSMDDY","sequence_length":606,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"d1928149d94b03fba5359df93e3d3d48b9719f04f979141e2a567d05bb8cd6a6","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q8C8N2.json","taxon_id":"10090","uniprot_accession":"Q8C8N2","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/scai-pf12070.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12070","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/scai-pf12070.yaml"}],"pfam_ids":["PF12070"],"protein_name":"Protein SCAI","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MVRGARQPQQPRSRLAPRLTGTVEKPPRKRRSRTEFALKEIMSSGGAEDDIPQGERKTVTDFCYLLDKSKQLFNGLRDLPQYGQKQWQSYFGRTFDVYTKLWKFQQQHRQVLDNRYGLKRWQIGEIASKIGQLYYHYYLRTSETSYLNEAFSFYSAIRQRSYYSQVNKEDRPELVVKKLRYYARFIVVCLLLNKMDVVKDLVKELSDEIEDYTHRFNTEDQVEWNLVLQEVAAFIEADPVMVLNDDNTIVITSNRLAETGAPLLEQGMIVGQLSLADALIIGNCNNQVKFSELTVDMFRMLQALEREPMNLASQMNKPGMQESADKPTRRENPHKYLLYKPTFSQLYTFLAASFKELPANSVLLIYLSATGVFPTGRSDSEGPYDFGGVLTNSNRDIINGDAIHKRNQSHKEMHCLHPGDLYPFTRKPLFIIVDSSNSVAYKNFTNLFGQPLVCLLSPTAYPKALQDQSQRGSLFTLFLNNPLMAFLFVSGLSSMRRGLWEKCQEYLRKINRDIAQLLTHSRSIDQAFLQFFGDEFLRLLLTRFIFCSATMRMHKIFRETRNYPESYPQLPRDETVENPHLQKHILELASILDVRNVFFENTIDDY","sequence_length":606,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"4a702a86027a3e71d9df67f31d7d72596a006b0ae5cdcb4d28e8ebbcfe1d0d3c","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q8N9R8.json","taxon_id":"9606","uniprot_accession":"Q8N9R8","uniprot_release":"2026_03"}],"pfam_id":"PF12070","short_name":"SCAI","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
