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This entry also includes RNF207, which has a similar organisation.","domain_architectures":72,"interpro_id":"IPR021978","known_evidence_count":null,"matches":1358,"name":"PML-like, coiled-coil","partial_evidence_count":null,"pfam_id":"PF12126","proteins":1276,"proteomes":427,"short_name":"PML_CC","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12126","structures":11,"taxa":1440,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF12126.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1093,"domain_architectures":72,"matches":1358,"proteins":1276,"proteomes":427,"structures":11,"taxa":1440},"curation_status":"SEEDED","description":"This is the coiled-coil region of PML, also known as TRIM19. PML acts in association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, such as tumour, suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. PML is defined by the TRIM/RBCC motif which consists of an N-terminal RING zinc finger, two BBox type zinc fingers followed by a coiled-coil region [[cite:PUB00102048]]. This coiled-coil region is thought to mediate interactions with cytomegalovirus IE1 protein and/or other partners [[cite:PUB00102048]]. This entry also includes RNF207, which has a similar organisation.","id":"Pfam:PF12126","interpro_id":"InterPro:IPR021978","name":"PML-like, coiled-coil","pfam_id":"PF12126","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"PML_CC","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12126"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF12126.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"9866fba3af517c1f801581cd2474d91d259d03afc8272152958b18761a737b13"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo 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