{"cross_mech":[],"family":{"alphafold_models":429,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents a group of fungal beta-mannosyltransferase that are involved in cell wall biosynthesis [[cite:PUB00086020]]. For example, in Candida albicans, BMT1-4 enzymes act stepwise to add beta-mannoses on to cell-wall phosphopeptidomannan (PPM). While Bmt5 and Bmt6 are involved in the addition of the first and third beta-mans to phospholipomannan (PLM), respectively [[cite:PUB00097617]]. Furthermore, in Saccharomyces cerevisiae, BMT5 and BMT6 are responsible for methylation of uridine residues in the 25S rRNA [[cite:PUB00075659]].","domain_architectures":14,"interpro_id":"IPR021988","known_evidence_count":null,"matches":808,"name":"Beta-mannosyltransferases","partial_evidence_count":null,"pfam_id":"PF12141","proteins":525,"proteomes":154,"short_name":"BMT","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12141","structures":0,"taxa":389,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF12141.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":429,"domain_architectures":14,"matches":808,"proteins":525,"proteomes":154,"structures":0,"taxa":389},"curation_status":"SEEDED","description":"This entry represents a group of fungal beta-mannosyltransferase that are involved in cell wall biosynthesis [[cite:PUB00086020]]. For example, in Candida albicans, BMT1-4 enzymes act stepwise to add beta-mannoses on to cell-wall phosphopeptidomannan (PPM). While Bmt5 and Bmt6 are involved in the addition of the first and third beta-mans to phospholipomannan (PLM), respectively [[cite:PUB00097617]]. Furthermore, in Saccharomyces cerevisiae, BMT5 and BMT6 are responsible for methylation of uridine residues in the 25S rRNA [[cite:PUB00075659]].","id":"Pfam:PF12141","interpro_id":"InterPro:IPR021988","name":"Beta-mannosyltransferases","pfam_id":"PF12141","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"BMT","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12141"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF12141.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"0bae4b3b6bc92525e33827734a91abf1027b7567fa35708b11501a329e80e9ea"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Candida albicans (strain SC5314 / ATCC 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