{"cross_mech":[],"family":{"alphafold_models":2263,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"TTD, tandem tudor domain within UHRF1 preferentially binds H3 histone tails trimethylated at Lys-9. It specifically recognises H3 tail peptides with the heterochromatin-associated modification state of trimethylated lysine 9 and unmodified lysine 4 (H3K4me0/K9me3). This domain is found in eukaryotes and is found in association with [pfam:PF00097], [pfam:PF02182], [pfam:PF00628], [pfam:PF00240].","domain_architectures":42,"interpro_id":"IPR021991","known_evidence_count":null,"matches":2573,"name":"Tandem tudor domain within UHRF1","partial_evidence_count":null,"pfam_id":"PF12148","proteins":2551,"proteomes":973,"short_name":"TTD","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12148","structures":27,"taxa":3282,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF12148.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2263,"domain_architectures":42,"matches":2573,"proteins":2551,"proteomes":973,"structures":27,"taxa":3282},"curation_status":"SEEDED","description":"TTD, tandem tudor domain within UHRF1 preferentially binds H3 histone tails trimethylated at Lys-9. It specifically recognises H3 tail peptides with the heterochromatin-associated modification state of trimethylated lysine 9 and unmodified lysine 4 (H3K4me0/K9me3). This domain is found in eukaryotes and is found in association with [pfam:PF00097], [pfam:PF02182], [pfam:PF00628], [pfam:PF00240].","id":"Pfam:PF12148","interpro_id":"InterPro:IPR021991","name":"Tandem tudor domain within UHRF1","pfam_id":"PF12148","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"TTD","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12148"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF12148.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"215ad6b82e8f69e2a40e66caca44f87a2e15f39ac47c10b4634b94e00a8f1ddc"}},"protein_examples":{"candidate_count":4,"discovery_scanned":true,"example_count":4,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/ttd-pf12148.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12148","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/ttd-pf12148.yaml"}],"pfam_ids":["PF00240","PF00628","PF02182","PF12148"],"protein_name":"E3 ubiquitin-protein ligase UHRF2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MWIQVRTIDGSQTRTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLENGYTLFDYDVGLNDIIQLLVRPDSSLPSTSKQNDAQVKPSSHNPPKVKKTARGGSSSQPSTSARTCLIDPGFGLYKVNELVDARDVGLGAWFEAHIHSVTRASDGHSRGKTPLKNGSSYKRTNGNVNHNSKENTNKLDNVPSTSNSDSVAADEDVIYHIEYDEYPESGILEMNVKDLRPRARTILKWNELNVGDVVMVNYNVENPGKRGFWYDAEITTLKTISRTKKEVRVKVFLGGSEGTLNDCRVMSVDEIFKIEKPGAHPISFADGKFLRKNDPECDLCGGDPDKTCHMCSCHKCGEKRDPNMQLLCDECNMAYHIYCLSPPLDKVPEEEYWYCPSCKTDSSEVVKAGERLKLSKKKAKMPSASTESRRDWGRGMACVGRTKECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFEDEVDRGDEFTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYWPEISSSHGFLVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGYPSEKEGKKTKGQSKKQGSEATKRPASDDECPGDSKVLKASDSTDAVEAFQLTPQQQRLIREDCQNQKLWDEVLASLVEGPNFLKKLEQSFMCVCCQELVYQPVTTECFHNVCKDCLQRSFKAQVFSCPACRHDLGQNYVMVLNETLQTLLDLFFPGYSKGR","sequence_length":803,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"71e58f200d9f7c0b33424b9f801f24f7f016da787c9e7e6027f1ee0aab781590","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q7TMI3.json","taxon_id":"10090","uniprot_accession":"Q7TMI3","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/ttd-pf12148.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12148","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/ttd-pf12148.yaml"}],"pfam_ids":["PF00240","PF00628","PF02182","PF12148"],"protein_name":"E3 ubiquitin-protein ligase UHRF1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MWIQVRTMDGKETHTVNSLSRLTKVQELRKKIEEVFHVEPQLQRLFYRGKQMEDGHTLFDYDVRLNDTIQLLVRQSLALPLSTKERDSELSDSDSGYGVGHSESDKSSTHGEGAAEADDKTVWEDTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKRALSEDEPCSSSAVKTSEDDIMYHVKYDDYPEHGVDIVKAKNVRARARTVIPWENLEVGQVVMANYNVDYPRKRGFWYDVEICRKRQTRTARELYGNIRLLNDSQLNNCRIMFVDEVLMIELPKERRPLIASPSQPPPALRNTGKSGPSCRFCKDDENKPCRKCACHVCGGREAPEKQLLCDECDMAFHLYCLKPPLTSVPPEPEWYCPSCRTDSSEVVQAGEKLKESKKKAKMASATSSSRRDWGKGMACVGRTTECTIVPANHFGPIPGVPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYEDDVDNGNYFTYTGSGGRDLSGNKRTAGQSSDQKLTNNNRALALNCHSPINEKGAEAEDWRQGKPVRVVRNMKGGKHSKYAPAEGNRYDGIYKVVKYWPERGKSGFLVWRYLLRRDDTEPEPWTREGKDRTRQLGLTMQYPEGYLEALANKEKSRKRPAKALEQGPSSSKTGKSKQKSTGPTLSSPRASKKSKLEPYTLSEQQANLIKEDKGNAKLWDDVLTSLQDGPYQIFLSKVKEAFQCICCQELVFRPVTTVCQHNVCKDCLDRSFRAQVFSCPACRFELDHSSPTRVNQPLQTILNQLFPGYGSGR","sequence_length":782,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"508ea3cc2387735e8db31632a7d18db2a747c2ca889fdad2a59c907af06c2e73","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q8VDF2.json","taxon_id":"10090","uniprot_accession":"Q8VDF2","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/ttd-pf12148.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12148","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/ttd-pf12148.yaml"}],"pfam_ids":["PF00240","PF00628","PF02182","PF12148"],"protein_name":"E3 ubiquitin-protein ligase UHRF2","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLENGYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARARLIDPGFGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQSRGKTPLKNGSSCKRTNGNIKHKSKENTNKLDSVPSTSNSDCVAADEDVIYHIQYDEYPESGTLEMNVKDLRPRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTISRTKKELRVKIFLGGSEGTLNDCKIISVDEIFKIERPGAHPLSFADGKFLRRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIYCLNPPLDKVPEEEYWYCPSCKTDSSEVVKAGERLKMSKKKAKMPSASTESRRDWGRGMACVGRTRECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFADEVDRGDEFTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYWPEISSSHGFLVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGYPSDKEGKKPKGQSKKQPSGTTKRPISDDDCPSASKVYKASDSAEAIEAFQLTPQQQHLIREDCQNQKLWDEVLSHLVEGPNFLKKLEQSFMCVCCQELVYQPVTTECFHNVCKDCLQRSFKAQVFSCPACRHDLGQNYIMIPNEILQTLLDLFFPGYSKGR","sequence_length":802,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"4b5db2e85525f49b3bc2250680cd698dc9b8db6736375ddea7011116bf83ed69","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q96PU4.json","taxon_id":"9606","uniprot_accession":"Q96PU4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/ttd-pf12148.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12148","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/ttd-pf12148.yaml"}],"pfam_ids":["PF00240","PF00628","PF02182","PF12148"],"protein_name":"E3 ubiquitin-protein ligase UHRF1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFYRGKQMEDGHTLFDYEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKSSTHGEAAAETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRDEPCSSTSRPALEEDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEISRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGSPMVDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDPPLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRTKECTIVPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYEDDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDWRSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDDEPGPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKWKRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPASGSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLGRSYAMQVNQPLQTVLNQLFPGYGNGR","sequence_length":793,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"0076040428b7f909caf2ddfe8f2c4f199dce3c4cdf29c33dbe4f6c4f7ad23c25","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q96T88.json","taxon_id":"9606","uniprot_accession":"Q96T88","uniprot_release":"2026_03"}],"pfam_id":"PF12148","short_name":"TTD","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}