{"cross_mech":[],"family":{"alphafold_models":619,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"Proteins in this entry contain a DEP domain, which is a globular domain of about 80 residues. This entry includes vacuolar membrane-associated protein Iml1 and DEP domain-containing protein 5/DDB_G0279099. In Saccharomyces cerevisiae, Iml1 is a subunit of both the SEA (Seh1-associated) and Iml1 complexes (Iml1-Npr2-Npr3). SEA complex is associates dynamically with the vacuole and is involved in autophagy [[cite:PUB00063317],[cite:PUB00063319]]. Iml1 complex is required for non-nitrogen-starvation (NNS)-induced autophagy [[cite:PUB00063318]]. This is a vWA-like domain.","domain_architectures":128,"interpro_id":"IPR048255","known_evidence_count":null,"matches":4910,"name":"Vacuolar membrane-associated protein Iml1, vWA-like domain","partial_evidence_count":null,"pfam_id":"PF12257","proteins":4843,"proteomes":2798,"short_name":"vWA_IML1","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12257","structures":15,"taxa":7363,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF12257.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":619,"domain_architectures":128,"matches":4910,"proteins":4843,"proteomes":2798,"structures":15,"taxa":7363},"curation_status":"SEEDED","description":"Proteins in this entry contain a DEP domain, which is a globular domain of about 80 residues. This entry includes vacuolar membrane-associated protein Iml1 and DEP domain-containing protein 5/DDB_G0279099. In Saccharomyces cerevisiae, Iml1 is a subunit of both the SEA (Seh1-associated) and Iml1 complexes (Iml1-Npr2-Npr3). SEA complex is associates dynamically with the vacuole and is involved in autophagy [[cite:PUB00063317],[cite:PUB00063319]]. Iml1 complex is required for non-nitrogen-starvation (NNS)-induced autophagy [[cite:PUB00063318]]. This is a vWA-like domain.","id":"Pfam:PF12257","interpro_id":"InterPro:IPR048255","name":"Vacuolar membrane-associated protein Iml1, vWA-like domain","pfam_id":"PF12257","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"vWA_IML1","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12257"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF12257.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"641990ec96be262a410ebed8c34f807eb90810fd1f8c11040dfab86a601d60ce"}},"protein_examples":{"candidate_count":7,"discovery_scanned":true,"example_count":7,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Aspergillus clavatus 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