{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF12398","protein_label":"","reviewed":null,"short_name":"DUF3660","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/s-locus-receptor-kinase-ipr022126.yaml","source_record_id":"InterPro:IPR022126","source_record_label":"S-locus, receptor kinase","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12398","protein_label":"Receptor-like serine/threonine-protein kinase SD1-6","reviewed":true,"short_name":"DUF3660","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3403-pf11883.yaml","source_record_id":"Pfam:PF11883","source_record_label":"Domain of unknown function (DUF3403)","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9S972","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12398","protein_label":"G-type lectin S-receptor-like serine/threonine-protein kinase SRK","reviewed":true,"short_name":"DUF3660","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3660-pf12398.yaml","source_record_id":"Pfam:PF12398","source_record_label":"Receptor serine/threonine kinase","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"P0DH86","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12398","protein_label":"Receptor-like serine/threonine-protein kinase SD1-7","reviewed":true,"short_name":"DUF3660","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3660-pf12398.yaml","source_record_id":"Pfam:PF12398","source_record_label":"Receptor serine/threonine kinase","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q39086","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12398","protein_label":"Receptor-like serine/threonine-protein kinase SD1-6","reviewed":true,"short_name":"DUF3660","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3660-pf12398.yaml","source_record_id":"Pfam:PF12398","source_record_label":"Receptor serine/threonine kinase","source_section":"canonical_examples","taxon_id":"NCBITaxon:3702","taxon_label":"Arabidopsis thaliana","uniprot_accession":"Q9S972","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF12398","protein_label":"","reviewed":null,"short_name":"DUF3660","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf3660-pf12398.yaml","source_record_id":"Pfam:PF12398","source_record_label":"Receptor serine/threonine kinase","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"KNOWN_HISTORICAL_DUF"}],"family":{"alphafold_models":520,"candidate_reasons":["short_name_matches_duf"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":2},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with [pfam:PF00954], [pfam:PF01453], [pfam:PF00069], [pfam:PF08276]. There is a conserved ELPL sequence motif.","domain_architectures":68,"interpro_id":"IPR022126","known_evidence_count":null,"matches":684,"name":"Receptor serine/threonine kinase","partial_evidence_count":null,"pfam_id":"PF12398","proteins":672,"proteomes":196,"short_name":"DUF3660","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12398","structures":0,"taxa":551,"unknown_status":"KNOWN_HISTORICAL_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF12398.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":520,"domain_architectures":68,"matches":684,"proteins":672,"proteomes":196,"structures":0,"taxa":551},"curation_status":"SEEDED","description":"This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with [pfam:PF00954], [pfam:PF01453], [pfam:PF00069], [pfam:PF08276]. There is a conserved ELPL sequence motif.","id":"Pfam:PF12398","interpro_id":"InterPro:IPR022126","name":"Receptor serine/threonine kinase","pfam_id":"PF12398","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"KNOWN_HISTORICAL_DUF","short_name":"DUF3660","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12398"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF12398.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"64b730b62d88bd64ffd33bf0d1437eb2158be7abf34ceb9bb4d772c0f2298d58"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf3660-pf12398.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12398","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf3660-pf12398.yaml"}],"pfam_ids":["PF00954","PF01453","PF07714","PF08276","PF11883","PF12398"],"protein_name":"G-type lectin S-receptor-like serine/threonine-protein kinase SRK","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRGELPNKHHSYTFFVFLFFFLILFPDLSISVNTLSATESLTISSNKTIVSPGGVFELGFFRILGDSWYLGIWYKKISQRTYVWVANRDTPLSNPIGILKISNANLVILDNSDTHVWSTNLTGAVRSSVVAELLDNGNFVLRGSKINESDEFLWQSFDFPTDTLLPQMKLGRDHKRGLNRFVTSWKSSFDPSSGSFMFKLETLGLPEFFGFTSFLEVYRSGPWDGLRFSGILEMQQWDDIIYNFTENREEVAYTFRVTDHNSYSRLTINTVGRLEGFMWEPTQQEWNMFWFMPKDTCDLYGICGPYAYCDMSTSPTCNCIKGFQPLSPQDWASGDVTGRCRRKTQLTCGEDRFFRLMNMKIPATTAAIVDKRIGLKECEEKCKTHCNCTAYANSDIRNGGSGCIIWIGEFRDIRNYAADGQDLFVRLAAAEFGERRTIRGKIIGLIIGISLMLVLSFIIYCFWKKKQKRARATAAPIGYRDRIQELIITNGVVMSSGRRLLGEEEDLELPLTEFETVVMATENFSDSNILGRGGFGIVYKGRLLDGQEIAVKRLSEMSSQGTNEFKNEVRLIARLQHINLVRLLSCCIYADEKILIYEYLENGSLDSHLFETTQSSNKLNWQTRFSIINGIARGLLYLHQDSRFKIIHRDLKASNVLLDKNMTPKISDFGMARIFERDETEANTRKVVGTYGYMSPEYAMEGIFSVKSDVFSFGVLVLEIVSGKRNRGFHNSGQDNNLLGYTWENWKEGKGLEIVDSIIVDSSSSMSLFQPHEVLRCIQIGLLCVQERAEDRPKMSSVVLMLGSEKGEIPQPKRPGYCVGRSSLDTADSSSSTKRDSESLTVNQITVSVINAR","sequence_length":853,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"49819b7dede907ee93894d381addbc50bb3835131bb67ee48ee264ab5541110d","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P0DH86.json","taxon_id":"3702","uniprot_accession":"P0DH86","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf3660-pf12398.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12398","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf3660-pf12398.yaml"}],"pfam_ids":["PF00954","PF01453","PF07714","PF08276","PF11883","PF12398"],"protein_name":"Receptor-like serine/threonine-protein kinase SD1-7","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRSVPNYHHSFFIFLILILFLAFSVSPNTLSATESLTISSNKTIISPSQIFELGFFNPASSSRWYLGIWYKIIPIRTYVWVANRDNPLSSSNGTLKISGNNLVIFDQSDRPVWSTNITGGDVRSPVAAELLDNGNFLLRDSNNRLLWQSFDFPTDTLLAEMKLGWDQKTGFNRILRSWKTTDDPSSGEFSTKLETSEFPEFYICSKESILYRSGPWNGMRFSSVPGTIQVDYMVYNFTASKEEVTYSYRINKTNLYSRLYLNSAGLLQRLTWFETTQSWKQLWYSPKDLCDNYKVCGNFGYCDSNSLPNCYCIKGFKPVNEQAWDLRDGSAGCMRKTRLSCDGRDGFTRLKRMKLPDTTATIVDREIGLKVCKERCLEDCNCTAFANADIRNGGSGCVIWTREILDMRNYAKGGQDLYVRLAAAELEDKRIKNEKIIGSSIGVSILLLLSFVIFHFWKRKQKRSITIQTPNVDQVRSQDSLINDVVVSRRGYTSKEKKSEYLELPLLELEALATATNNFSNDNKLGQGGFGIVYKGRLLDGKEIAVKRLSKMSSQGTDEFMNEVRLIAKLQHINLVRLLGCCVDKGEKMLIYEYLENLSLDSHLFDQTRSSNLNWQKRFDIINGIARGLLYLHQDSRCRIIHRDLKASNVLLDKNMTPKISDFGMARIFGREETEANTRRVVGTYGYMSPEYAMDGIFSMKSDVFSFGVLLLEIISGKRNKGFYNSNRDLNLLGFVWRHWKEGNELEIVDPINIDSLSSKFPTHEILRCIQIGLLCVQERAEDRPVMSSVMVMLGSETTAIPQPKRPGFCIGRSPLEADSSSSTQRDDECTVNQITLSVIDAR","sequence_length":843,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"b72cf8cd9cbdf39e381a9825bfd95b10df6de4cd1b676657c1ebd54f8fa302d4","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q39086.json","taxon_id":"3702","uniprot_accession":"Q39086","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Arabidopsis thaliana","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf3403-pf11883.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF11883","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf3403-pf11883.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf3660-pf12398.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12398","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf3660-pf12398.yaml"}],"pfam_ids":["PF00954","PF01453","PF07714","PF08276","PF11883","PF12398"],"protein_name":"Receptor-like serine/threonine-protein kinase SD1-6","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRNVPNYHHSYFILFIIILFLAFSVYASNFSATESLTISSNKTIISPSQIFELGFFNPDSSSRWYLGIWYKIIPIRTYVWVANRDNPLSSSNGTLKISDNNLVIFDQSDRPVWSTNITGGDVRSPVAAELLDYGNFVLRDSKNNKPSGFLWQSFDFPTDTLLSDMKMGWDNKSGGFNRILRSWKTTDDPSSGDFSTKLRTSGFPEFYIYNKESITYRSGPWLGNRFSSVPGMKPVDYIDNSFTENNQQVVYSYRVNKTNIYSILSLSSTGLLQRLTWMEAAQSWKQLWYSPKDLCDNYKECGNYGYCDANTSPICNCIKGFEPMNEQAALRDDSVGCVRKTKLSCDGRDGFVRLKKMRLPDTTETSVDKGIGLKECEERCLKGCNCTAFANTDIRNGGSGCVIWSGGLFDIRNYAKGGQDLYVRVAAGDLEDKRIKSKKIIGSSIGVSILLLLSFIIFHFWKRKQKRSITIQTPIVDLVRSQDSLMNELVKASRSYTSKENKTDYLELPLMEWKALAMATNNFSTDNKLGQGGFGIVYKGMLLDGKEIAVKRLSKMSSQGTDEFMNEVRLIAKLQHINLVRLLGCCVDKGEKMLIYEYLENLSLDSHLFDQTRSSNLNWQKRFDIINGIARGLLYLHQDSRCRIIHRDLKASNVLLDKNMTPKISDFGMARIFGREETEANTRRVVGTYGYMSPEYAMDGIFSMKSDVFSFGVLLLEIISGKRNKGFYNSNRDLNLLGFVWRHWKEGKELEIVDPINIDALSSEFPTHEILRCIQIGLLCVQERAEDRPVMSSVMVMLGSETTAIPQPKRPGFCVGRSSLEVDSSSSTQRDDECTVNQVTLSVIDAR","sequence_length":847,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"96b5d60e7cb00ae3ab89c3d0d0495fc62d505c5805d9d17388d07e472a63b3a4","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q9S972.json","taxon_id":"3702","uniprot_accession":"Q9S972","uniprot_release":"2026_03"}],"pfam_id":"PF12398","short_name":"DUF3660","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}