{"cross_mech":[],"family":{"alphafold_models":3588,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"STIMATE is a ER-resident multi-transmembrane protein that serves as a positive regulator of Ca(2+) influx in vertebrates. It interacts with ER-resident Ca2+ sensor protein STIM1 to promote STIM1 conformational switch [[cite:PUB00076888]]. This entry also includes budding yeast YPL162C.","domain_architectures":63,"interpro_id":"IPR022127","known_evidence_count":null,"matches":4139,"name":"STIMATE family","partial_evidence_count":null,"pfam_id":"PF12400","proteins":4107,"proteomes":2598,"short_name":"STIMATE","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12400","structures":0,"taxa":6732,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF12400.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3588,"domain_architectures":63,"matches":4139,"proteins":4107,"proteomes":2598,"structures":0,"taxa":6732},"curation_status":"SEEDED","description":"STIMATE is a ER-resident multi-transmembrane protein that serves as a positive regulator of Ca(2+) influx in vertebrates. It interacts with ER-resident Ca2+ sensor protein STIM1 to promote STIM1 conformational switch [[cite:PUB00076888]]. This entry also includes budding yeast YPL162C.","id":"Pfam:PF12400","interpro_id":"InterPro:IPR022127","name":"STIMATE family","pfam_id":"PF12400","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"STIMATE","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12400"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF12400.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"4c295e82f66939913ac73b1f467a9e066f28f503daf7a387859dc00e6810dc0a"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/stimate-pf12400.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12400","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/stimate-pf12400.yaml"}],"pfam_ids":["PF12400"],"protein_name":"Vacuolar membrane protein YPL162C","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MYVSNGKDTCQLLGPVSLFVQTLMGMTAVIVLLVKRNYEHPRRKMIVWSYDIGKQIIGSLGIHFLNLGISILKKRRRSLFAITAKGNDDEDQCDWYFLNLLLDTTVGIPILWLCLYIIEKVLKSLHFQNIESGNYFPSKTVGSHPRKPLFSAFVKQLLIFIVGLGVMKFCVFLILNYLEDLAYWFADLILGWSDSWPNFQVFLVMFVFPILLNCFQYFCVDNVIRLHSESLTITNAENFETNTFLNDEIPDLSEVSNEVPNKDNNISSYGSII","sequence_length":273,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"c85e332bb6c236adbbbf1c85fe8fee7818e4d1a53d0abda4c8eda3c6e31db8d0","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q12042.json","taxon_id":"559292","uniprot_accession":"Q12042","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/stimate-pf12400.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12400","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/stimate-pf12400.yaml"}],"pfam_ids":["PF12400"],"protein_name":"Store-operated calcium entry regulator STIMATE","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MQGPGGNVSRGLPSGPASTVASGAGRCESGALMHSFGIFLQGLLGVVAFSTLMLKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVGVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNAFMFWVVDNFLMRKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDAEEDLRRPVKKKHRFGLPV","sequence_length":288,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"5cf8eaa5842070d7fe05d1ad79cb41156a7b5a5eaca36938cc8c853d69274cfc","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q3UF25.json","taxon_id":"10090","uniprot_accession":"Q3UF25","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/stimate-pf12400.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12400","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/stimate-pf12400.yaml"}],"pfam_ids":["PF12400"],"protein_name":"Store-operated calcium entry regulator STIMATE","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MQGPAGNASRGLPGGPPSTVASGAGRCESGALMHSFGIFLQGLLGVVAFSTLMLKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFWVVDNFLMRKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDVEEDLRRLTPLKPVKKKKHRFGLPV","sequence_length":294,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"92d2bf1e35bbdb05357bd239d5a7a4e8619b52e7b777b60bb57447c782713ee9","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q86TL2.json","taxon_id":"9606","uniprot_accession":"Q86TL2","uniprot_release":"2026_03"}],"pfam_id":"PF12400","short_name":"STIMATE","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}