{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12404","protein_label":"Peptidase B","reviewed":true,"short_name":"DUF3663","source_category":"function/protein_family/ncbifam","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/protein_family/ncbifam/aminopeptidase-pepb-nf003450.yaml","source_record_id":"NCBIfam:NF003450","source_record_label":"aminopeptidase PepB","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P37095","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12404","protein_label":"Peptidase B","reviewed":true,"short_name":"DUF3663","source_category":"sequence/domain/cdd","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/cdd/cytosol-aminopeptidase-family-n-terminal-and-catalytic-domains-family--cd00433.yaml","source_record_id":"CDD:cd00433","source_record_label":"Peptidase_M17","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P37095","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12404","protein_label":"Peptidase B","reviewed":true,"short_name":"DUF3663","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/peptidase-m17-leucyl-aminopeptidase-c-terminal-ipr000819.yaml","source_record_id":"InterPro:IPR000819","source_record_label":"Peptidase M17, leucyl aminopeptidase, C-terminal","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P37095","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12404","protein_label":"Peptidase B","reviewed":true,"short_name":"DUF3663","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/peptidase-m17-peptidase-b-like-n-terminal-domain-ipr047620.yaml","source_record_id":"InterPro:IPR047620","source_record_label":"Peptidase M17, peptidase B-like, N-terminal domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P37095","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF12404","protein_label":"","reviewed":null,"short_name":"DUF3663","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/peptidase-m17-peptidase-b-like-n-terminal-domain-ipr047620.yaml","source_record_id":"InterPro:IPR047620","source_record_label":"Peptidase M17, peptidase B-like, N-terminal domain","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12404","protein_label":"Peptidase B","reviewed":true,"short_name":"DUF3663","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf3663-pf12404.yaml","source_record_id":"Pfam:PF12404","source_record_label":"Peptidase","source_section":"canonical_examples","taxon_id":"NCBITaxon:399742","taxon_label":"Enterobacter sp. (strain 638)","uniprot_accession":"A4WDA4","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12404","protein_label":"Peptidase B","reviewed":true,"short_name":"DUF3663","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf3663-pf12404.yaml","source_record_id":"Pfam:PF12404","source_record_label":"Peptidase","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P37095","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12404","protein_label":"Peptidase B","reviewed":true,"short_name":"DUF3663","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf3663-pf12404.yaml","source_record_id":"Pfam:PF12404","source_record_label":"Peptidase","source_section":"canonical_examples","taxon_id":"NCBITaxon:99287","taxon_label":"Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)","uniprot_accession":"Q9RF52","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF12404","protein_label":"","reviewed":null,"short_name":"DUF3663","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf3663-pf12404.yaml","source_record_id":"Pfam:PF12404","source_record_label":"Peptidase","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12404","protein_label":"Peptidase B","reviewed":true,"short_name":"DUF3663","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/peptidase-m17-pf00883.yaml","source_record_id":"Pfam:PF00883","source_record_label":"Cytosol aminopeptidase family, catalytic domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P37095","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12404","protein_label":"Peptidase B","reviewed":true,"short_name":"DUF3663","source_category":"sequence/pattern","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/pattern/cytosol-ap.yaml","source_record_id":"PROSITE:PS00631","source_record_label":"Cytosol aminopeptidase signature","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P37095","unknown_status":"KNOWN_HISTORICAL_DUF"}],"family":{"alphafold_models":843,"candidate_reasons":["short_name_matches_duf"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":7},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain family is found in bacteria, and is approximately 80 amino acids in length. The family is found in association with [pfam:PF00883]. There is a conserved WAF sequence motif.","domain_architectures":3,"interpro_id":"IPR047620","known_evidence_count":null,"matches":1373,"name":"Peptidase","partial_evidence_count":null,"pfam_id":"PF12404","proteins":1373,"proteomes":1262,"short_name":"DUF3663","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12404","structures":3,"taxa":1750,"unknown_status":"KNOWN_HISTORICAL_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF12404.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":843,"domain_architectures":3,"matches":1373,"proteins":1373,"proteomes":1262,"structures":3,"taxa":1750},"curation_status":"SEEDED","description":"This domain family is found in bacteria, and is approximately 80 amino acids in length. The family is found in association with [pfam:PF00883]. There is a conserved WAF sequence motif.","id":"Pfam:PF12404","interpro_id":"InterPro:IPR047620","name":"Peptidase","pfam_id":"PF12404","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"KNOWN_HISTORICAL_DUF","short_name":"DUF3663","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12404"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF12404.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"4fa1183c50b280c9a031778d1c486e72b709f33e73c70686da8726e98da2a7a4"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Enterobacter sp. (strain 638)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf3663-pf12404.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12404","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf3663-pf12404.yaml"}],"pfam_ids":["PF00883","PF12404"],"protein_name":"Peptidase B","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTEAMNITLSTQPADARWGEKATYSINNDGITLHLNGSDDLGLIQRAARKIDGLGIKHVTLAGEGWDTDRSWAFWAGYKGPKGTRKIEWANLDEAGQKELESRLMIIDWVRDTINAPAEELGPEQLAQRAVDLLCKAAGDKMSYRITKGEDLREQNYMGLHTVGRGSERPPVLLALDYNPTGDKQAPVYACLVGKGITFDTGGYSLKQSAFMDSMKSDMGGAATITGALAFAITRGLNKRVKLYLCCADNMVSGNAFKLGDIIRYRNGKNVEVMNTDAEGRLVLADGLIDASAQKPELIIDMATLTGAAKTALGNDYHALFTFDDKLASRLMASAAAENEPFWRLPLAEFHRSQLPSNFAELNNTASAAYPAGASTAAGFLSHFVENYHEGWLHIDCSATYRKAGVEQWSAGATGLGVRTIANLLTAE","sequence_length":428,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"1915df5023e4e53331d9b866b7b117332ddcdac084612e99d0a1c19e99d56b97","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A4WDA4.json","taxon_id":"399742","uniprot_accession":"A4WDA4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/aminopeptidase-pepb-nf003450.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF003450","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/aminopeptidase-pepb-nf003450.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/cytosol-aminopeptidase-family-n-terminal-and-catalytic-domains-family--cd00433.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd00433","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/cytosol-aminopeptidase-family-n-terminal-and-catalytic-domains-family--cd00433.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/peptidase-m17-leucyl-aminopeptidase-c-terminal-ipr000819.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR000819","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/peptidase-m17-leucyl-aminopeptidase-c-terminal-ipr000819.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/peptidase-m17-peptidase-b-like-n-terminal-domain-ipr047620.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR047620","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/peptidase-m17-peptidase-b-like-n-terminal-domain-ipr047620.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf3663-pf12404.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12404","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf3663-pf12404.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/peptidase-m17-pf00883.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF00883","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/peptidase-m17-pf00883.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/pattern/cytosol-ap.yaml","qualification_status":"NOT_ASSESSED","record_id":"PROSITE:PS00631","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/pattern/cytosol-ap.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P37095","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF00883","PF12404"],"protein_name":"Peptidase B","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"9b07b6c183458bd13efa4ba57ac2c12e8e2f0e131c88ba72d07169d5eed4c62e","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MTEAMKITLSTQPADARWGEKATYSINNDGITLHLNGADDLGLIQRAARKIDGLGIKHVQLSGEGWDADRCWAFWQGYKAPKGTRKVVWPDLDDAQRQELDNRLMIIDWVRDTINAPAEELGPSQLAQRAVDLISNVAGDRVTYRITKGEDLREQGYMGLHTVGRGSERSPVLLALDYNPTGDKEAPVYACLVGKGITFDSGGYSIKQTAFMDSMKSDMGGAATVTGALAFAITRGLNKRVKLFLCCADNLISGNAFKLGDIITYRNGKKVEVMNTDAEGRLVLADGLIDASAQKPEMIIDAATLTGAAKTALGNDYHALFSFDDALAGRLLASAAQENEPFWRLPLAEFHRSQLPSNFAELNNTGSAAYPAGASTAAGFLSHFVENYQQGWLHIDCSATYRKAPVEQWSAGATGLGVRTIANLLTA","sequence_length":427,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"9b07b6c183458bd13efa4ba57ac2c12e8e2f0e131c88ba72d07169d5eed4c62e","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/P37095.json","taxon_id":"83333","uniprot_accession":"P37095","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf3663-pf12404.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12404","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf3663-pf12404.yaml"}],"pfam_ids":["PF00883","PF12404"],"protein_name":"Peptidase B","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTEAMKITLSTQPADARWGDKATYSINNDGITLHLNGKDDLGLIQRAARKIDGLGIKQVALTGEGWDTERCWAFWAGYKGPKGVRTVMWPDLDDAQRQELDNRLTIIDWVRDTINAPAEELGPEQLAQRAVDLLCSVACDSVTYRITKGEDLREQNYMGLHTVGRGSERPPVLLALDYNPTGDKDAPVYACLVGKGITFDSGGYSIKQSAFMDSMKSDMGGAATVTGALAFAITRGLNKRVKLFLCCADNLISGNAFKLGDIIRYRNGKNVEVMNTDAEGRLVLADGLIDASAQHPQLIIDMATLTGAAKTALGNDYHALFSFDDTLAGRLLTSAAQENEPFWRLPLAEFHRNQLPSNFAELNNTGSAAYPAGASTAAGFLSHFVENYREGWLHIDCSATYRKAPVEQWAAGATGLGVRTIANLLTA","sequence_length":427,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"a31c4dfca0fc2ff01ba2c2cd4323c2cf3233f2a368d58a5062cfc880be901e91","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9RF52.json","taxon_id":"99287","uniprot_accession":"Q9RF52","uniprot_release":"2026_03"}],"pfam_id":"PF12404","short_name":"DUF3663","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}