{"cross_mech":[],"family":{"alphafold_models":54,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents the C-terminal receptor binding domain of Tip attachment protein J from Escherichia phage lambda (GpJ) and similar bacterial and viral proteins. J attaches the virion to the host receptor LamB, inducing viral DNA ejection. This domain, which determines the host specificity of the phage, shows an immunoglobulin-like fold [[cite:PUB00155963],[cite:PUB00109155]]. Many of the proteins in this entry are annotated as fibronectin type III. This domain was previously known as DUF3672 and is normally found associated with [pfam:PF09327] and [pfam:PF13550].","domain_architectures":5,"interpro_id":"IPR021034","known_evidence_count":null,"matches":91,"name":"Tip attachment protein J, C-terminal receptor binding domain","partial_evidence_count":null,"pfam_id":"PF12421","proteins":91,"proteomes":58,"short_name":"Ig_GpJ_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12421","structures":9,"taxa":172,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF12421.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":54,"domain_architectures":5,"matches":91,"proteins":91,"proteomes":58,"structures":9,"taxa":172},"curation_status":"SEEDED","description":"This entry represents the C-terminal receptor binding domain of Tip attachment protein J from Escherichia phage lambda (GpJ) and similar bacterial and viral proteins. J attaches the virion to the host receptor LamB, inducing viral DNA ejection. This domain, which determines the host specificity of the phage, shows an immunoglobulin-like fold [[cite:PUB00155963],[cite:PUB00109155]]. Many of the proteins in this entry are annotated as fibronectin type III. This domain was previously known as DUF3672 and is normally found associated with [pfam:PF09327] and [pfam:PF13550].","id":"Pfam:PF12421","interpro_id":"InterPro:IPR021034","name":"Tip attachment protein J, C-terminal receptor binding domain","pfam_id":"PF12421","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Ig_GpJ_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12421"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF12421.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"9faa83a6980d12a0cfbb443964c0c044c96c209602ffc7a6cd867d3e455ff58b"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia phage lambda","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/fniii-a-gpj-pf24801.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF24801","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/fniii-a-gpj-pf24801.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/ig-gpj-c-pf12421.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12421","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/ig-gpj-c-pf12421.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/ig-j-pf24421.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF24421","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/ig-j-pf24421.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/ig-j-second-pf24489.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF24489","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/ig-j-second-pf24489.yaml"}],"pfam_ids":["PF09327","PF12421","PF13550","PF24421","PF24489","PF24801"],"protein_name":"Tip attachment protein J","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGKGSSKGHTPREAKDNLKSTQLLSVIDAISEGPIEGPVDGLKSVLLNSTPVLDTEGNTNISGVTVVFRAGEQEQTPPEGFESSGSETVLGTEVKYDTPITRTITSANIDRLRFTFGVQALVETTSKGDRNPSEVRLLVQIQRNGGWVTEKDITIKGKTTSQYLASVVMGNLPPRPFNIRMRRMTPDSTTDQLQNKTLWSSYTEIIDVKQCYPNTALVGVQVDSEQFGSQQVSRNYHLRGRILQVPSNYNPQTRQYSGIWDGTFKPAYSNNMAWCLWDMLTHPRYGMGKRLGAADVDKWALYVIGQYCDQSVPDGFGGTEPRITCNAYLTTQRKAWDVLSDFCSAMRCMPVWNGQTLTFVQDRPSDKTWTYNRSNVVMPDDGAPFRYSFSALKDRHNAVEVNWIDPNNGWETATELVEDTQAIARYGRNVTKMDAFGCTSRGQAHRAGLWLIKTELLETQTVDFSVGAEGLRHVPGDVIEICDDDYAGISTGGRVLAVNSQTRTLTLDREITLPSSGTALISLVDGSGNPVSVEVQSVTDGVKVKVSRVPDGVAEYSVWELKLPTLRQRLFRCVSIRENDDGTYAITAVQHVPEKEAIVDNGAHFDGEQSGTVNGVTPPAVQHLTAEVTADSGEYQVLARWDTPKVVKGVSFLLRLTVTADDGSERLVSTARTTETTYRFTQLALGNYRLTVRAVNAWGQQGDPASVSFRIAAPAAPSRIELTPGYFQITATPHLAVYDPTVQFEFWFSEKQIADIRQVETSTRYLGTALYWIAASINIKPGHDYYFYIRSVNTVGKSAFVEAVGRASDDAEGYLDFFKGKITESHLGKELLEKVELTEDNASRLEEFSKEWKDASDKWNAMWAVKIEQTKDGKHYVAGIGLSMEDTEEGKLSQFLVAANRIAFIDPANGNETPMFVAQGNQIFMNDVFLKRLTAPTITSGGNPPAFSLTPDGKLTAKNADISGSVNANSGTLSNVTIAENCTINGTLRAEKIVGDIVKAASAAFPRQRESSVDWPSGTRTVTVTDDHPFDRQIVVLPLTFRGSKRTVSGRTTYSMCYLKVLMNGAVIYDGAANEAVQVFSRIVDMPAGRGNVILTFTLTSTRHSADIPPYTFASDVQVMVIKKQALGISVV","sequence_length":1132,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"08ac2d5fc2e1b7633310d801e26ffd4a0dc06e33b66ce7d0d967193eeb7dfe78","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P03749.json","taxon_id":"2681611","uniprot_accession":"P03749","uniprot_release":"2026_03"}],"pfam_id":"PF12421","short_name":"Ig_GpJ_C","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}