{"cross_mech":[],"family":{"alphafold_models":1670,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain is found in Golgi associated RAB2 interactor proteins and it is likely a Rab2B-binding domain [[cite:PUB00100833],[cite:PUB00100832],[cite:PUB00100834]]. Some members included in this entry, such as GAR1A/B and GAR2, are RAB2B effector proteins required for accurate acrosome formation and normal male fertility [[cite:PUB00100833],[cite:PUB00100834]]. GARI-L4 is a RAB2B effector protein required for the compacted Golgi morphology [[cite:PUB00100832]]. GARIL5 is a Rab2B effector protein which promotes cytosolic DNA-induced innate immune responses [[cite:PUB00100835]].","domain_architectures":34,"interpro_id":"IPR022168","known_evidence_count":null,"matches":2570,"name":"Golgi associated RAB2 interactor protein-like, Rab2B-binding domain","partial_evidence_count":null,"pfam_id":"PF12480","proteins":2442,"proteomes":325,"short_name":"GARIL_Rab2_bd","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12480","structures":0,"taxa":1056,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF12480.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1670,"domain_architectures":34,"matches":2570,"proteins":2442,"proteomes":325,"structures":0,"taxa":1056},"curation_status":"SEEDED","description":"This domain is found in Golgi associated RAB2 interactor proteins and it is likely a Rab2B-binding domain [[cite:PUB00100833],[cite:PUB00100832],[cite:PUB00100834]]. Some members included in this entry, such as GAR1A/B and GAR2, are RAB2B effector proteins required for accurate acrosome formation and normal male fertility [[cite:PUB00100833],[cite:PUB00100834]]. GARI-L4 is a RAB2B effector protein required for the compacted Golgi morphology [[cite:PUB00100832]]. GARIL5 is a Rab2B effector protein which promotes cytosolic DNA-induced innate immune responses [[cite:PUB00100835]].","id":"Pfam:PF12480","interpro_id":"InterPro:IPR022168","name":"Golgi associated RAB2 interactor protein-like, Rab2B-binding 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TASOR 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