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It may act as a chaperone in the early steps of COX2 maturation [[cite:PUB00088297]].","domain_architectures":29,"interpro_id":"IPR022533","known_evidence_count":null,"matches":2679,"name":"Cytochrome c oxidase assembly protein COX20","partial_evidence_count":null,"pfam_id":"PF12597","proteins":2661,"proteomes":2417,"short_name":"Cox20","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12597","structures":0,"taxa":6450,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF12597.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2317,"domain_architectures":29,"matches":2679,"proteins":2661,"proteomes":2417,"structures":0,"taxa":6450},"curation_status":"SEEDED","description":"Complex IV (CIV) is a copper-heme oxidase that couples electron transfer from cytochrome c to oxygen with proton extrusion across the inner membrane to contribute to the proton gradient required for ATP generation. 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